- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04830878
Methotrexate For The Prevention and Treatment of Proliferative Vitreoretinopathy in Pediatric Patients (SIGHT)
April 18, 2023 updated by: Stanford University
A Phase I, Multicenter, Uncontrolled, Open Label Study Assessing the Efficacy and Safety of a Combination of Systemic and Intravitreal Injections of Methotrexate for the Prevention and Treatment of Proliferative Vitreoretinopathy in Pediatric Patients With RheGmatogenous Retinal DetacHmenT (the SIGHT Study)
Rhegmatogenous retinal detachment (RRD) is a sight-threatening condition.
Children with RRD usually present late with clinical features of longstanding RRD, specifically a serious condition named: proliferative vitreoretinopathy (PVR).
Therefore, children with RRD often have poorer outcomes.
The objective of this study is to investigate the efficacy and safety of methotrexate in the treatment and prevention of PVR.
Methotrexate is a medication that has been used to treat inflammatory conditions in children and adults for a long time and it has been recently used to treat PVR in adults.
Study Overview
Status
Withdrawn
Conditions
Intervention / Treatment
Study Type
Interventional
Phase
- Phase 1
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Edward H. Wood, MD
- Phone Number: (650) 723-6995
- Email: ehw@stanford.edu
Study Locations
-
-
California
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Palo Alto, California, United States, 94303
- Byers Eye Institute at Stanford University and Lucille Packard Children Hospital
-
Contact:
- Edward Wood, MD
- Phone Number: 650-723-6995
- Email: ehw@stanford.edu
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
No older than 18 years (Child, Adult)
Accepts Healthy Volunteers
No
Description
Inclusion Criteria:
- Ability to get informed consent from a parent or a legal guardian of the child and attend all study visits.
- Males or females 18 years old or younger.
- Subject is undergoing vitrectomy for either i. initial retinal detachment with or without PVR ii. recurrent retinal detachment due to grade A or higher of proliferative vitreoretinopathy.
- Female subjects of childbearing potential must not be pregnant or breast-feeding, must have a negative serum pregnancy test at screening, and must be willing to undergo pregnancy tests throughout the study.
- Female subjects of childbearing potential and male subjects able to father children must (a) abstain from intercourse throughout the course of the study or (b) agree to practice acceptable methods of contraception throughout the course of the study (i.e., intrauterine device, oral contraceptives, barrier method, or other contraception deemed adequate by the investigator).
Exclusion Criteria:
Ocular or periocular infection in either eye including (but not limited to):
- History of herpetic infection in the study eye(s) or adnexa.
- Presence of known active or inactive toxoplasmosis or toxoplasmosis scar in either eye.
- History of cytomegalovirus infection or clinical evidence of active cytomegalovirus infection at screening and/or Day 1.
- Pupillary dilation inadequate for quality stereoscopic fundus photography in the study eye(s).
- Media opacity that would limit clinical visualization in the study eye(s) and, in the opinion of the investigator, could not be repaired or improved during the RD surgery.
- Other planned eye surgery during the course of the trial
- Corneal opacity in the study eye(s) that would preclude reliable assessment of the posterior segment.
- Uncontrolled glaucoma in the study eye(s), evidenced by an intraocular pressure (IOP) > 21 mmHg while on maximum medical therapy, or chronic hypotony (unmeasurable eye pressure).
- Subjects should not be currently undergoing treatment with one of the following at the time of RD diagnosis: systemic steroids, methotrexate, azathioprine, or mycophenolate mofetil (or an equivalent drug, e.g., mycophenolic acid) or other immunomodulatory therapies.
- Malignancy in remission for less than 5 years prior to study participation.
- Allergy or hypersensitivity to investigational product or other study related procedures/medications.
- Any recent systemic infection (excluding common cold) within 30 days of Day 1.
- Known to be immunocompromised.
- History of other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease condition that contraindicates the use of an investigational drug, might affect the interpretation of the results of the study, or renders the subject at high risk for treatment complications.
- Any uncontrolled systemic disease, except stable syndromic conditions.
- Females who are pregnant or lactating and females of child-bearing potential who are not using adequate contraceptive precautions (i.e., intrauterine device, oral contraceptives, barrier method, or other contraception deemed adequate by the investigator).
- Participation in other investigational drug (oral or topical therapy) or device clinical trials within 30 days prior to Day 1 and/or participation in other investigational drug (intravitreal injection therapy) within 3 months or 5 half-lives (whichever is longer) prior to Day 1 or planning to participate in other investigational drug or device clinical trials during a time which would overlap with the duration of the study. This includes both ocular and non-ocular clinical trials. Exposure to investigational biologics should be discussed with the investigators.
- In addition, the investigator may declare a subject ineligible for any sound reason.
- Chest X-ray within 3 months prior to initiation of systemic MTX that shows active pulmonary diseases of any etiology.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Prevention
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Treatment
Methotrexate treatment
|
Systemic and intraoperative intravitreal injection of methotrexate
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Recurrence of Retinal Detachment
Time Frame: 6 months
|
Number of Participants with Recurrent Retinal Detachment
|
6 months
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Edward Wood, MD, Stanford University
- Principal Investigator: Quan Dong Nguyen, MD, MSc, Stanford University
- Principal Investigator: Ahmad Al-Moujahed, MD, PhD, MPH, Stanford University
- Principal Investigator: Hashem Ghoraba, MD, Stanford University
- Principal Investigator: Darius Moshfeghi, MD, Stanford University
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Anticipated)
April 1, 2021
Primary Completion (Anticipated)
April 1, 2023
Study Completion (Anticipated)
April 1, 2024
Study Registration Dates
First Submitted
March 31, 2021
First Submitted That Met QC Criteria
March 31, 2021
First Posted (Actual)
April 5, 2021
Study Record Updates
Last Update Posted (Actual)
April 20, 2023
Last Update Submitted That Met QC Criteria
April 18, 2023
Last Verified
April 1, 2023
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Eye Diseases
- Retinal Diseases
- Vitreoretinopathy, Proliferative
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Nucleic Acid Synthesis Inhibitors
- Enzyme Inhibitors
- Antirheumatic Agents
- Antimetabolites, Antineoplastic
- Antimetabolites
- Antineoplastic Agents
- Immunosuppressive Agents
- Immunologic Factors
- Dermatologic Agents
- Reproductive Control Agents
- Abortifacient Agents, Nonsteroidal
- Abortifacient Agents
- Folic Acid Antagonists
- Methotrexate
Other Study ID Numbers
- IRB-59989
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Yes
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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