- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05063552
Testing the Use of Investigational Drugs Atezolizumab and/or Bevacizumab With or Without Standard Chemotherapy in the Second-Line Treatment of Advanced-Stage Head and Neck Cancers
A Phase II/III Trial of Chemotherapy + Cetuximab vs Chemotherapy + Bevacizumab vs Atezolizumab + Bevacizumab Following Progression on Immune Checkpoint Inhibition in Recurrent/Metastatic Head and Neck Cancers
Study Overview
Status
Conditions
- Recurrent Head and Neck Squamous Cell Carcinoma
- Recurrent Hypopharyngeal Squamous Cell Carcinoma
- Recurrent Laryngeal Squamous Cell Carcinoma
- Metastatic Head and Neck Squamous Cell Carcinoma
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Stage IV Hypopharyngeal Carcinoma AJCC v8
- Stage IV Laryngeal Cancer AJCC v8
- Stage IV Lip and Oral Cavity Cancer AJCC v8
- Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
- Metastatic Hypopharyngeal Squamous Cell Carcinoma
- Metastatic Laryngeal Squamous Cell Carcinoma
- Metastatic Lip and Oral Cavity Carcinoma
- Metastatic Nasal Cavity Squamous Cell Carcinoma
- Metastatic Nasopharyngeal Squamous Cell Carcinoma
- Metastatic Pharyngeal Squamous Cell Carcinoma
- Metastatic Sinonasal Squamous Cell Carcinoma
- Recurrent Lip and Oral Cavity Squamous Cell Carcinoma
- Recurrent Nasopharyngeal Squamous Cell Carcinoma
- Recurrent Pharyngeal Squamous Cell Carcinoma
- Recurrent Sinonasal Squamous Cell Carcinoma
- Stage IV Nasopharyngeal Carcinoma AJCC v8
- Stage IV Sinonasal Cancer AJCC v8
Intervention / Treatment
Detailed Description
PRIMARY OBJECTIVES:
I. To evaluate progression-free survival (PFS) of patients treated with chemotherapy plus cetuximab, chemotherapy plus bevacizumab, and atezolizumab plus bevacizumab. (Phase II) II. To evaluate the overall survival (OS) of patients treated with chemotherapy plus cetuximab to the superior arm from the phase II portion of the protocol. (Phase III)
SECONDARY OBJECTIVES:
I. To evaluate the OS for the subset of patients with high PD-L1 expression, defined as combined positive score (CPS) >= 20% on all arms of treatment.
II. To evaluate the toxicity of each arm of treatment.
IMAGING OBJECTIVES:
I. To establish the correlation between fludeoxyglucose F-18 (18F-FDG) positron emission tomography (PET) and computed tomography (CT) neck imaging biomarkers (maximum standard uptake value [SUVmax], metabolic tumor volume [MTV], total lesion glycolysis [TLG], tumor volume) and expression of PD-L1 expression (Low versus high, defined as CPS < 20 versus CPS >= 20).
II. To determine if 18FDG-PET/CT and CT neck imaging biomarkers at baseline will predict treatment response at nine to twelve weeks post the initiation of treatment, PFS, and OS.
EXPLORATORY OBJECTIVE:
I. To establish the correlation between 18F-FDG PET and CT neck radiomics features and PD-L1 expressions (Low versus high - defined as CPS < 20 versus CPS >= 20).
OUTLINE: This is a randomized phase II trial followed by a randomized phase III trial.
PHASE II: Patients are randomized to 1 of 3 arms.
ARM A: Patients receive cetuximab intravenously (IV) over 60-120 minutes on days 1, 8, and 15 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 or days 1 and 15 of each cycle of maintenance therapy. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or magnetic resonance imaging (MRI) throughout the trial. Patients may undergo echocardiography (ECHO) during screening.
ARM B: Patients receive bevacizumab IV over 30-90 minutes on day 1 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive bevacizumab IV over 30-60 minutes on day 1 of each cycle of maintenance therapy. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial. Patients may undergo ECHO during screening.
ARM C: Patients receive bevacizumab IV over 30-90 minutes on day 1 and atezolizumab over 30-60 minutes on day 1 of each cycle. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial. Patients may undergo ECHO during screening.
PHASE III: Patients are randomized to 1 of 2 arms.
ARM A: Patients receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle. Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity. Patients then receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 or days 1 and 15 of each cycle of maintenance therapy. Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity. Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial. Patients may undergo ECHO during screening.
ARM B: Patients receive treatment as in Arm B or C above based on results of the Phase II trial.
Patients undergo blood sample collection throughout the study.
After completion of study treatment, patients are followed up at 30 days and then every 3 months if patient is < 2 years from randomization and every 6 months if patient is 2-5 years from randomization.
Study Type
Enrollment (Estimated)
Phase
- Phase 2
- Phase 3
Contacts and Locations
Study Locations
-
-
Arkansas
-
Little Rock, Arkansas, United States, 72205
- Active, not recruiting
- University of Arkansas for Medical Sciences
-
-
California
-
Dublin, California, United States, 94568
- Recruiting
- Epic Care-Dublin
-
Contact:
- Site Public Contact
- Phone Number: 925-875-1677
-
Principal Investigator:
- Lisa Bailey
-
Emeryville, California, United States, 94608
- Recruiting
- Epic Care Partners in Cancer Care
-
Principal Investigator:
- Lisa Bailey
-
Contact:
- Site Public Contact
- Phone Number: 510-629-6682
-
Martinez, California, United States, 94553-3156
- Recruiting
- Contra Costa Regional Medical Center
-
Principal Investigator:
- Lisa Bailey
-
Contact:
- Site Public Contact
- Phone Number: 925-957-5400
-
Palo Alto, California, United States, 94304
- Recruiting
- Stanford Cancer Institute Palo Alto
-
Principal Investigator:
- Saad A. Khan
-
Contact:
- Site Public Contact
- Phone Number: 650-498-7061
- Email: ccto-office@stanford.edu
-
Palo Alto, California, United States, 94304
- Recruiting
- VA Palo Alto Health Care System
-
Contact:
- Site Public Contact
- Phone Number: 800-455-0057
-
Principal Investigator:
- Harlan A. Pinto
-
-
Connecticut
-
Derby, Connecticut, United States, 06418
- Recruiting
- Smilow Cancer Hospital-Derby Care Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Fairfield, Connecticut, United States, 06824
- Recruiting
- Smilow Cancer Hospital Care Center-Fairfield
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Glastonbury, Connecticut, United States, 06033
- Recruiting
- Smilow Cancer Hospital Care Center at Glastonbury
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Greenwich, Connecticut, United States, 06830
- Recruiting
- Smilow Cancer Hospital Care Center at Greenwich
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Guilford, Connecticut, United States, 06437
- Recruiting
- Smilow Cancer Hospital Care Center - Guilford
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Hartford, Connecticut, United States, 06105
- Recruiting
- Smilow Cancer Hospital Care Center at Saint Francis
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
New Haven, Connecticut, United States, 06520
- Recruiting
- Yale University
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
North Haven, Connecticut, United States, 06473
- Recruiting
- Yale-New Haven Hospital North Haven Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Orange, Connecticut, United States, 06477
- Recruiting
- Smilow Cancer Hospital-Orange Care Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Stamford, Connecticut, United States, 06902
- Recruiting
- Smilow Cancer Hospital Care Center at Long Ridge
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Torrington, Connecticut, United States, 06790
- Recruiting
- Smilow Cancer Hospital-Torrington Care Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Trumbull, Connecticut, United States, 06611
- Recruiting
- Smilow Cancer Hospital Care Center-Trumbull
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Waterbury, Connecticut, United States, 06708
- Recruiting
- Smilow Cancer Hospital-Waterbury Care Center
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
Waterford, Connecticut, United States, 06385
- Recruiting
- Smilow Cancer Hospital Care Center - Waterford
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
-
Delaware
-
Newark, Delaware, United States, 19713
- Recruiting
- Helen F Graham Cancer Center
-
Principal Investigator:
- Gregory A. Masters
-
Contact:
- Site Public Contact
- Phone Number: 302-623-4450
- Email: lbarone@christianacare.org
-
Newark, Delaware, United States, 19713
- Recruiting
- Medical Oncology Hematology Consultants PA
-
Principal Investigator:
- Gregory A. Masters
-
Contact:
- Site Public Contact
- Phone Number: 302-623-4450
- Email: lbarone@christianacare.org
-
-
District of Columbia
-
Washington, District of Columbia, United States, 20010
- Recruiting
- MedStar Washington Hospital Center
-
Contact:
- Site Public Contact
- Phone Number: 202-877-8839
-
Principal Investigator:
- Irina G. Veytsman
-
-
Florida
-
Coral Gables, Florida, United States, 33146
- Recruiting
- UM Sylvester Comprehensive Cancer Center at Coral Gables
-
Contact:
- Site Public Contact
- Phone Number: 305-243-2647
-
Principal Investigator:
- Chukwuemeka (Emeka) V. Ikpeazu
-
Deerfield Beach, Florida, United States, 33442
- Recruiting
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach
-
Contact:
- Site Public Contact
- Phone Number: 305-243-2647
-
Principal Investigator:
- Chukwuemeka (Emeka) V. Ikpeazu
-
Fort Lauderdale, Florida, United States, 33316
- Recruiting
- Broward Health Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 302-651-5572
- Email: Allison.bruce@nemours.org
-
Principal Investigator:
- Shannon B. Keating
-
Miami, Florida, United States, 33136
- Recruiting
- University of Miami Miller School of Medicine-Sylvester Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 305-243-2647
-
Principal Investigator:
- Chukwuemeka (Emeka) V. Ikpeazu
-
Miami, Florida, United States, 33176
- Recruiting
- UM Sylvester Comprehensive Cancer Center at Kendall
-
Contact:
- Site Public Contact
- Phone Number: 305-243-2647
-
Principal Investigator:
- Chukwuemeka (Emeka) V. Ikpeazu
-
Plantation, Florida, United States, 33324
- Recruiting
- UM Sylvester Comprehensive Cancer Center at Plantation
-
Contact:
- Site Public Contact
- Phone Number: 305-243-2647
-
Principal Investigator:
- Chukwuemeka (Emeka) V. Ikpeazu
-
-
Georgia
-
Atlanta, Georgia, United States, 30322
- Recruiting
- Emory University Hospital/Winship Cancer Institute
-
Contact:
- Site Public Contact
- Phone Number: 404-778-1868
-
Principal Investigator:
- Nabil F. Saba
-
Atlanta, Georgia, United States, 30308
- Recruiting
- Emory University Hospital Midtown
-
Contact:
- Site Public Contact
- Phone Number: 888-946-7447
-
Principal Investigator:
- Nabil F. Saba
-
-
Hawaii
-
'Aiea, Hawaii, United States, 96701
- Recruiting
- Hawaii Cancer Care - Westridge
-
Contact:
- Site Public Contact
- Phone Number: 808-539-2273
- Email: info@hawaiicancercare.com
-
Principal Investigator:
- Yoshihito Saito
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Hawaii Cancer Care Inc - Waterfront Plaza
-
Contact:
- Site Public Contact
- Phone Number: 808-524-6115
- Email: i.webster@hawaiicancercare.com
-
Principal Investigator:
- Yoshihito Saito
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Queen's Cancer Cenrer - POB I
-
Contact:
- Site Public Contact
- Phone Number: 808-532-0315
-
Principal Investigator:
- Yoshihito Saito
-
Honolulu, Hawaii, United States, 96813
- Recruiting
- Queen's Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 808-545-8548
-
Principal Investigator:
- Yoshihito Saito
-
Honolulu, Hawaii, United States, 96817
- Recruiting
- Queen's Cancer Center - Kuakini
-
Contact:
- Site Public Contact
- Phone Number: 808-531-8521
-
Principal Investigator:
- Yoshihito Saito
-
-
Idaho
-
Boise, Idaho, United States, 83712
- Recruiting
- Saint Luke's Cancer Institute - Boise
-
Principal Investigator:
- Alison K. Conlin
-
Contact:
- Site Public Contact
- Phone Number: 208-381-2774
- Email: eslinget@slhs.org
-
Fruitland, Idaho, United States, 83619
- Recruiting
- Saint Luke's Cancer Institute - Fruitland
-
Principal Investigator:
- Alison K. Conlin
-
Contact:
- Site Public Contact
- Phone Number: 208-381-2774
- Email: eslinget@slhs.org
-
Meridian, Idaho, United States, 83642
- Recruiting
- Saint Luke's Cancer Institute - Meridian
-
Principal Investigator:
- Alison K. Conlin
-
Contact:
- Site Public Contact
- Phone Number: 208-381-2774
- Email: eslinget@slhs.org
-
Nampa, Idaho, United States, 83686
- Recruiting
- Saint Luke's Cancer Institute - Nampa
-
Principal Investigator:
- Alison K. Conlin
-
Contact:
- Site Public Contact
- Phone Number: 208-381-2774
- Email: eslinget@slhs.org
-
Twin Falls, Idaho, United States, 83301
- Recruiting
- Saint Luke's Cancer Institute - Twin Falls
-
Principal Investigator:
- Alison K. Conlin
-
Contact:
- Site Public Contact
- Phone Number: 208-381-2774
- Email: eslinget@slhs.org
-
-
Illinois
-
Aurora, Illinois, United States, 60504
- Recruiting
- Rush - Copley Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 630-978-6212
- Email: Cancer.Research@rushcopley.com
-
Principal Investigator:
- Prem Sobti
-
Chicago, Illinois, United States, 60637
- Recruiting
- University of Chicago Comprehensive Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 773-702-8222
- Email: cancerclinicaltrials@bsd.uchicago.edu
-
Principal Investigator:
- Ari J. Rosenberg
-
Chicago, Illinois, United States, 60612
- Recruiting
- John H Stroger Jr Hospital of Cook County
-
Contact:
- Site Public Contact
- Phone Number: 312-864-5204
-
Principal Investigator:
- Thomas E. Lad
-
Chicago, Illinois, United States, 60612
- Suspended
- University of Illinois
-
Danville, Illinois, United States, 61832
- Recruiting
- Carle at The Riverfront
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Prem Sobti
-
Effingham, Illinois, United States, 62401
- Recruiting
- Carle Physician Group-Effingham
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Prem Sobti
-
Harvey, Illinois, United States, 60426
- Recruiting
- Ingalls Memorial Hospital
-
Principal Investigator:
- James A. Wallace
-
Contact:
- Site Public Contact
- Phone Number: 708-915-4673
- Email: clinicaltrials@ingalls.org
-
Mattoon, Illinois, United States, 61938
- Recruiting
- Carle Physician Group-Mattoon/Charleston
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Prem Sobti
-
New Lenox, Illinois, United States, 60451
- Recruiting
- UC Comprehensive Cancer Center at Silver Cross
-
Contact:
- Site Public Contact
- Phone Number: 773-702-8222
- Email: cancerclinicaltrials@bsd.uchicago.edu
-
Principal Investigator:
- Ari J. Rosenberg
-
Orland Park, Illinois, United States, 60462
- Recruiting
- University of Chicago Medicine-Orland Park
-
Contact:
- Site Public Contact
- Phone Number: 773-702-8222
- Email: cancerclinicaltrials@bsd.uchicago.edu
-
Principal Investigator:
- Ari J. Rosenberg
-
Urbana, Illinois, United States, 61801
- Recruiting
- Carle Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-446-5532
- Email: Research@carle.com
-
Principal Investigator:
- Prem Sobti
-
Yorkville, Illinois, United States, 60560
- Recruiting
- Rush-Copley Healthcare Center
-
Contact:
- Site Public Contact
- Phone Number: 630-978-6212
- Email: Cancer.Research@rushcopley.com
-
Principal Investigator:
- Prem Sobti
-
-
Iowa
-
Ames, Iowa, United States, 50010
- Recruiting
- Mary Greeley Medical Center
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Ames, Iowa, United States, 50010
- Recruiting
- McFarland Clinic - Ames
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-239-4734
- Email: ksoder@mcfarlandclinic.com
-
Ankeny, Iowa, United States, 50023
- Recruiting
- Mission Cancer and Blood - Ankeny
-
Principal Investigator:
- Joshua Lukenbill
-
Contact:
- Site Public Contact
- Phone Number: 515-282-2921
-
Boone, Iowa, United States, 50036
- Recruiting
- McFarland Clinic - Boone
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Clive, Iowa, United States, 50325
- Recruiting
- Medical Oncology and Hematology Associates-West Des Moines
-
Contact:
- Site Public Contact
- Phone Number: 515-241-3305
-
Principal Investigator:
- Richard L. Deming
-
Clive, Iowa, United States, 50325
- Recruiting
- Mercy Cancer Center-West Lakes
-
Principal Investigator:
- Richard L. Deming
-
Contact:
- Site Public Contact
- Phone Number: 515-358-6613
- Email: cancerresearch@mercydesmoines.org
-
Creston, Iowa, United States, 50801
- Recruiting
- Greater Regional Medical Center
-
Principal Investigator:
- Richard L. Deming
-
Contact:
- Site Public Contact
- Phone Number: 515-358-6613
- Email: cancerresearch@mercydesmoines.org
-
Des Moines, Iowa, United States, 50309
- Recruiting
- Medical Oncology and Hematology Associates-Des Moines
-
Principal Investigator:
- Joshua Lukenbill
-
Contact:
- Site Public Contact
- Phone Number: 515-241-3305
-
Des Moines, Iowa, United States, 50314
- Recruiting
- Mercy Medical Center - Des Moines
-
Principal Investigator:
- Richard L. Deming
-
Contact:
- Site Public Contact
- Phone Number: 515-358-6613
- Email: cancerresearch@mercydesmoines.org
-
Des Moines, Iowa, United States, 50314
- Recruiting
- Mission Cancer and Blood - Laurel
-
Contact:
- Site Public Contact
- Phone Number: 515-241-3305
-
Principal Investigator:
- Richard L. Deming
-
Des Moines, Iowa, United States, 50309
- Recruiting
- Iowa Methodist Medical Center
-
Principal Investigator:
- Joshua Lukenbill
-
Contact:
- Site Public Contact
- Phone Number: 515-241-6727
-
Fort Dodge, Iowa, United States, 50501
- Recruiting
- McFarland Clinic - Trinity Cancer Center
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Jefferson, Iowa, United States, 50129
- Recruiting
- McFarland Clinic - Jefferson
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
Marshalltown, Iowa, United States, 50158
- Recruiting
- McFarland Clinic - Marshalltown
-
Principal Investigator:
- Joseph J. Merchant
-
Contact:
- Site Public Contact
- Phone Number: 515-956-4132
-
West Des Moines, Iowa, United States, 50266
- Recruiting
- Mercy Medical Center-West Lakes
-
Principal Investigator:
- Richard L. Deming
-
Contact:
- Site Public Contact
- Phone Number: 515-358-6613
- Email: cancerresearch@mercydesmoines.org
-
-
Maryland
-
Baltimore, Maryland, United States, 21287
- Recruiting
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 410-955-8804
- Email: jhcccro@jhmi.edu
-
Principal Investigator:
- Tanguy Y. Seiwert
-
Baltimore, Maryland, United States, 21201
- Recruiting
- University of Maryland/Greenebaum Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-888-8823
-
Principal Investigator:
- Ranee Mehra
-
Cumberland, Maryland, United States, 21502
- Recruiting
- UPMC Western Maryland
-
Contact:
- Site Public Contact
- Phone Number: 240-964-1400
-
Principal Investigator:
- Dan P. Zandberg
-
-
Massachusetts
-
Worcester, Massachusetts, United States, 01655
- Recruiting
- UMass Memorial Medical Center - University Campus
-
Principal Investigator:
- William V. Walsh
-
Contact:
- Site Public Contact
- Phone Number: 508-856-3216
- Email: cancer.research@umassmed.edu
-
-
Minnesota
-
Minneapolis, Minnesota, United States, 55407
- Recruiting
- Abbott-Northwestern Hospital
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- David M. King
-
Saint Louis Park, Minnesota, United States, 55416
- Recruiting
- Park Nicollet Clinic - Saint Louis Park
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- David M. King
-
Saint Paul, Minnesota, United States, 55101
- Recruiting
- Regions Hospital
-
Contact:
- Site Public Contact
- Phone Number: 952-993-1517
- Email: mmcorc@healthpartners.com
-
Principal Investigator:
- David M. King
-
-
New Hampshire
-
Lebanon, New Hampshire, United States, 03756
- Recruiting
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-639-6918
- Email: cancer.research.nurse@dartmouth.edu
-
Principal Investigator:
- Garrett T. Wasp
-
-
New Mexico
-
Albuquerque, New Mexico, United States, 87102
- Recruiting
- University of New Mexico Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 505-925-0348
- Email: HSC-ClinicalTrialInfo@salud.unm.edu
-
Principal Investigator:
- Martha Mapalo
-
Las Cruces, New Mexico, United States, 88011
- Recruiting
- Memorial Medical Center - Las Cruces
-
Contact:
- Site Public Contact
- Phone Number: 575-556-6545
- Email: Kim.Hoffman@lpnt.net
-
Principal Investigator:
- Martha Mapalo
-
-
North Carolina
-
Clinton, North Carolina, United States, 28328
- Recruiting
- Southeastern Medical Oncology Center-Clinton
-
Contact:
- Site Public Contact
- Phone Number: 919-587-9084
- Email: jfields@cancersmoc.com
-
Principal Investigator:
- Samer S. Kasbari
-
Goldsboro, North Carolina, United States, 27534
- Recruiting
- Southeastern Medical Oncology Center-Goldsboro
-
Contact:
- Site Public Contact
- Phone Number: 919-587-9084
- Email: jfields@cancersmoc.com
-
Principal Investigator:
- Samer S. Kasbari
-
Jacksonville, North Carolina, United States, 28546
- Recruiting
- Southeastern Medical Oncology Center-Jacksonville
-
Principal Investigator:
- Samer S. Kasbari
-
Contact:
- Site Public Contact
- Phone Number: 910-587-9084
- Email: jfields@cancersmoc.com
-
-
Ohio
-
Centerville, Ohio, United States, 45459
- Recruiting
- Miami Valley Hospital South
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Tarek M. Sabagh
-
Dayton, Ohio, United States, 45409
- Recruiting
- Miami Valley Hospital
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Tarek M. Sabagh
-
Dayton, Ohio, United States, 45415
- Recruiting
- Dayton Physician LLC-Miami Valley Hospital North
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Howard M. Gross
-
Dayton, Ohio, United States, 45415
- Recruiting
- Miami Valley Hospital North
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Tarek M. Sabagh
-
Dayton, Ohio, United States, 45409
- Recruiting
- Dayton Blood and Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 937-276-8320
-
Principal Investigator:
- Tarek M. Sabagh
-
Franklin, Ohio, United States, 45005-1066
- Recruiting
- Atrium Medical Center-Middletown Regional Hospital
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Tarek M. Sabagh
-
Greenville, Ohio, United States, 45331
- Recruiting
- Miami Valley Cancer Care and Infusion
-
Principal Investigator:
- Tarek M. Sabagh
-
Contact:
- Site Public Contact
- Phone Number: 937-569-7515
-
Kettering, Ohio, United States, 45429
- Recruiting
- Kettering Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Howard M. Gross
-
Steubenville, Ohio, United States, 43952
- Recruiting
- Trinity's Tony Teramana Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 888-874-7000
-
Principal Investigator:
- Dan P. Zandberg
-
Toledo, Ohio, United States, 43623
- Recruiting
- Toledo Clinic Cancer Centers-Toledo
-
Principal Investigator:
- Rex B. Mowat
-
Contact:
- Site Public Contact
- Phone Number: 800-444-3561
-
Troy, Ohio, United States, 45373
- Recruiting
- Upper Valley Medical Center
-
Contact:
- Site Public Contact
- Phone Number: 937-528-2900
- Email: clinical.trials@daytonncorp.org
-
Principal Investigator:
- Tarek M. Sabagh
-
-
Oklahoma
-
Oklahoma City, Oklahoma, United States, 73104
- Recruiting
- University of Oklahoma Health Sciences Center
-
Contact:
- Site Public Contact
- Phone Number: 405-271-8777
- Email: ou-clinical-trials@ouhsc.edu
-
Principal Investigator:
- Minh Phan
-
-
Oregon
-
Clackamas, Oregon, United States, 97015
- Suspended
- Providence Cancer Institute Clackamas Clinic
-
Newberg, Oregon, United States, 97132
- Recruiting
- Providence Newberg Medical Center
-
Principal Investigator:
- Alison K. Conlin
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
Portland, Oregon, United States, 97213
- Recruiting
- Providence Portland Medical Center
-
Principal Investigator:
- Alison K. Conlin
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
Portland, Oregon, United States, 97225
- Recruiting
- Providence Saint Vincent Medical Center
-
Principal Investigator:
- Alison K. Conlin
-
Contact:
- Site Public Contact
- Phone Number: 503-215-2614
- Email: CanRsrchStudies@providence.org
-
-
Pennsylvania
-
Altoona, Pennsylvania, United States, 16601
- Recruiting
- UPMC Altoona
-
Contact:
- Site Public Contact
- Email: ecog.rss@jimmy.harvard.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Beaver, Pennsylvania, United States, 15009
- Recruiting
- UPMC-Heritage Valley Health System Beaver
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Butler, Pennsylvania, United States, 16001
- Recruiting
- UPMC Hillman Cancer Center at Butler Health System
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Camp Hill, Pennsylvania, United States, 17011
- Suspended
- UPMC Camp Hill
-
Carlisle, Pennsylvania, United States, 17015
- Recruiting
- Carlisle Regional Cancer Center
-
Contact:
- Site Public Contact
- Email: ecog.rss@jimmy.harvard.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Cranberry Township, Pennsylvania, United States, 16066
- Recruiting
- UPMC Hillman Cancer Center - Passavant - Cranberry
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Erie, Pennsylvania, United States, 16505
- Recruiting
- UPMC Hillman Cancer Center Erie
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Farrell, Pennsylvania, United States, 16121
- Recruiting
- UPMC Cancer Center at UPMC Horizon
-
Contact:
- Site Public Contact
- Email: ecog.rss@jimmy.harvard.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Greensburg, Pennsylvania, United States, 15601
- Recruiting
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Contact:
- Site Public Contact
- Phone Number: 724-838-1900
-
Principal Investigator:
- Dan P. Zandberg
-
Greenville, Pennsylvania, United States, 16125
- Recruiting
- Oncology Hematology Associates
-
Contact:
- Site Public Contact
- Email: ecog.rss@jimmy.harvard.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Greenville, Pennsylvania, United States, 16125
- Suspended
- UPMC Hillman Cancer Center in Greenville/UPMC Horizon
-
Harrisburg, Pennsylvania, United States, 17109
- Recruiting
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Contact:
- Site Public Contact
- Phone Number: 717-724-6765
- Email: klitchfield@PINNACLEHEALTH.org
-
Principal Investigator:
- Dan P. Zandberg
-
Indiana, Pennsylvania, United States, 15701
- Recruiting
- IRMC Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Johnstown, Pennsylvania, United States, 15901
- Recruiting
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 814-534-4724
-
Principal Investigator:
- Dan P. Zandberg
-
McKeesport, Pennsylvania, United States, 15132
- Recruiting
- UPMC Cancer Center at UPMC McKeesport
-
Contact:
- Site Public Contact
- Phone Number: 412-647-8073
-
Principal Investigator:
- Dan P. Zandberg
-
Mechanicsburg, Pennsylvania, United States, 17050
- Recruiting
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Monroeville, Pennsylvania, United States, 15146
- Recruiting
- Forbes Hospital
-
Contact:
- Site Public Contact
- Phone Number: 412-858-7746
-
Principal Investigator:
- Larisa Greenberg
-
Monroeville, Pennsylvania, United States, 15146
- Recruiting
- UPMC Hillman Cancer Center - Monroeville
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Moon, Pennsylvania, United States, 15108
- Recruiting
- UPMC Hillman Cancer Center in Coraopolis
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Mount Pleasant, Pennsylvania, United States, 15666
- Recruiting
- UPMC Hillman Cancer Center - Part of Frick Hospital
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
N. Huntingdon, Pennsylvania, United States, 15642
- Recruiting
- Arnold Palmer Cancer Center Medical Oncology Norwin
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Natrona Heights, Pennsylvania, United States, 15065
- Recruiting
- UPMC Cancer Center-Natrona Heights
-
Contact:
- Site Public Contact
- Phone Number: 724-230-3030
-
Principal Investigator:
- Dan P. Zandberg
-
New Castle, Pennsylvania, United States, 16105
- Recruiting
- UPMC Hillman Cancer Center - New Castle
-
Contact:
- Site Public Contact
- Phone Number: 412-389-5208
- Email: haneydl@upmc.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Philadelphia, Pennsylvania, United States, 19107
- Recruiting
- Thomas Jefferson University Hospital
-
Contact:
- Site Public Contact
- Phone Number: 215-600-9151
- Email: ONCTrialNow@jefferson.edu
-
Principal Investigator:
- Jennifer M. Johnson
-
Philadelphia, Pennsylvania, United States, 19114
- Recruiting
- Jefferson Torresdale Hospital
-
Contact:
- Site Public Contact
- Phone Number: 215-600-9151
- Email: ONCTrialNow@jefferson.edu
-
Principal Investigator:
- Jennifer M. Johnson
-
Philadelphia, Pennsylvania, United States, 19103
- Recruiting
- ECOG-ACRIN Cancer Research Group
-
Principal Investigator:
- Aarti Bhatia
-
Contact:
- Aarti Bhatia
- Email: aarti.bhatia@yale.edu
-
Pittsburgh, Pennsylvania, United States, 15232
- Recruiting
- University of Pittsburgh Cancer Institute (UPCI)
-
Contact:
- Site Public Contact
- Phone Number: 412-647-8073
-
Principal Investigator:
- Dan P. Zandberg
-
Pittsburgh, Pennsylvania, United States, 15215
- Recruiting
- UPMC-Saint Margaret
-
Contact:
- Site Public Contact
- Phone Number: 412-784-4900
-
Principal Investigator:
- Dan P. Zandberg
-
Pittsburgh, Pennsylvania, United States, 15219
- Recruiting
- UPMC-Mercy Hospital
-
Contact:
- Site Public Contact
- Phone Number: 800-533-8762
-
Principal Investigator:
- Dan P. Zandberg
-
Pittsburgh, Pennsylvania, United States, 15237
- Recruiting
- UPMC-Passavant Hospital
-
Contact:
- Site Public Contact
- Phone Number: 412-367-6454
-
Principal Investigator:
- Dan P. Zandberg
-
Pittsburgh, Pennsylvania, United States, 15243
- Recruiting
- UPMC-Saint Clair Hospital Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 412-502-3920
-
Principal Investigator:
- Dan P. Zandberg
-
Pittsburgh, Pennsylvania, United States, 15212
- Recruiting
- Allegheny General Hospital
-
Contact:
- Site Public Contact
- Phone Number: 877-284-2000
-
Principal Investigator:
- Larisa Greenberg
-
Seneca, Pennsylvania, United States, 16346
- Recruiting
- UPMC Cancer Center at UPMC Northwest
-
Contact:
- Site Public Contact
- Phone Number: 814-676-7900
-
Principal Investigator:
- Dan P. Zandberg
-
Uniontown, Pennsylvania, United States, 15401
- Recruiting
- UPMC Cancer Center-Uniontown
-
Contact:
- Site Public Contact
- Email: ecog.rss@jimmy.harvard.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Washington, Pennsylvania, United States, 15301
- Recruiting
- UPMC Cancer Center-Washington
-
Contact:
- Site Public Contact
- Email: ecog.rss@jimmy.harvard.edu
-
Principal Investigator:
- Dan P. Zandberg
-
West Mifflin, Pennsylvania, United States, 15122
- Recruiting
- UPMC West Mifflin-Cancer Center Jefferson
-
Contact:
- Site Public Contact
- Phone Number: 412-653-8100
-
Principal Investigator:
- Dan P. Zandberg
-
Williamsport, Pennsylvania, United States, 17754
- Recruiting
- Divine Providence Hospital
-
Contact:
- Site Public Contact
- Email: ecog.rss@jimmy.harvard.edu
-
Principal Investigator:
- Dan P. Zandberg
-
Willow Grove, Pennsylvania, United States, 19090
- Recruiting
- Asplundh Cancer Pavilion
-
Contact:
- Site Public Contact
- Phone Number: 215-600-9151
- Email: ONCTrialNow@jefferson.edu
-
Principal Investigator:
- Jennifer M. Johnson
-
York, Pennsylvania, United States, 17408
- Recruiting
- UPMC Memorial
-
Contact:
- Site Public Contact
- Phone Number: 717-724-6760
-
Principal Investigator:
- Dan P. Zandberg
-
-
Rhode Island
-
Westerly, Rhode Island, United States, 02891
- Recruiting
- Smilow Cancer Hospital Care Center - Westerly
-
Contact:
- Site Public Contact
- Phone Number: 203-785-5702
- Email: canceranswers@yale.edu
-
Principal Investigator:
- Aarti Bhatia
-
-
Tennessee
-
Knoxville, Tennessee, United States, 37916
- Active, not recruiting
- Thompson Cancer Survival Center
-
Knoxville, Tennessee, United States, 37932
- Active, not recruiting
- Thompson Cancer Survival Center - West
-
Lenoir City, Tennessee, United States, 37772
- Active, not recruiting
- Thompson Oncology Group-Lenoir City
-
Nashville, Tennessee, United States, 37232
- Recruiting
- Vanderbilt University/Ingram Cancer Center
-
Contact:
- Site Public Contact
- Phone Number: 800-811-8480
-
Principal Investigator:
- Jennifer H. Choe
-
Oak Ridge, Tennessee, United States, 37830
- Active, not recruiting
- Thompson Oncology Group-Oak Ridge
-
-
Vermont
-
Saint Johnsbury, Vermont, United States, 05819
- Recruiting
- Norris Cotton Cancer Center-North
-
Contact:
- Site Public Contact
- Phone Number: 800-639-6918
- Email: cancer.research.nurse@hitchcock.org
-
Principal Investigator:
- Garrett T. Wasp
-
-
West Virginia
-
Charleston, West Virginia, United States, 25304
- Recruiting
- West Virginia University Charleston Division
-
Contact:
- Site Public Contact
- Phone Number: 304-388-9944
-
Principal Investigator:
- Ahmed A. Khalid
-
-
Wisconsin
-
Mukwonago, Wisconsin, United States, 53149
- Recruiting
- ProHealth D N Greenwald Center
-
Contact:
- Site Public Contact
- Email: research.institute@phci.org
-
Principal Investigator:
- Timothy R. Wassenaar
-
Oconomowoc, Wisconsin, United States, 53066
- Recruiting
- ProHealth Oconomowoc Memorial Hospital
-
Principal Investigator:
- Timothy R. Wassenaar
-
Contact:
- Site Public Contact
- Phone Number: 262-928-7878
-
Waukesha, Wisconsin, United States, 53188
- Recruiting
- UW Cancer Center at ProHealth Care
-
Principal Investigator:
- Timothy R. Wassenaar
-
Contact:
- Site Public Contact
- Phone Number: 262-928-5539
- Email: Chanda.miller@phci.org
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Patient must have histologically confirmed squamous cell carcinoma of the head and neck (HNSCC) (excluding SCC of salivary glands, Epstein-Barr virus [EBV]-associated nasopharynx and skin)
- Patient must have measurable disease as defined by Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1. Measurements must be obtained within 4 weeks prior to randomization
- Patient must be >= 18 years of age
- Patient must have an Eastern Cooperative Oncology Group (ECOG) performance status 0-1
- Patient must have disease progression after prior therapy with an immune checkpoint inhibitor (ICI) in the first-line setting for recurrent/metastatic disease. Patient must have received first-line immune checkpoint inhibition for at least 6 weeks. Patients who have recurred or progressed within 12 weeks of immune checkpoint inhibition administered in the definitive setting for locally advanced disease (for e.g., in the context of a clinical trial) will also be eligible if local therapies are not feasible
- Prior combination immunotherapies are permitted, but patient must not have had prior antiangiogenic treatment (e.g., bevacizumab, ziv-aflibercept, ramucirumab, sorafenib, sunitinib, pazopanib, regorafenib, lenvatinib, etc.). Patient must have completed any prior investigational therapy at least 28 days prior to randomization.
NOTE: Patients who received platinum/taxanes in the locally-advanced or recurrent/metastatic setting and did not progress for at least 4 months thereafter, will be eligible for this study. Patients who received cetuximab in the locally-advanced setting and did not progress for at least 4 months thereafter, will also be eligible for this study
- Patient must not have a history of >= grade 3 immune-related adverse event on prior ICI therapy (except those that could be managed with steroids [e.g., dermatologic toxicity, asymptomatic elevation of pancreatic enzymes, etc.]) and ICI could eventually be resumed. Patients who developed grade 3 endocrinopathies but are now stable on hormone supplementation and/or a daily prednisone dose of =< 10 mg (or equivalent doses of another glucocorticoid), will be permitted on this trial
- Patient must not have a history of PD-1 inhibitor-induced hyper-progression, defined as 100% increase in tumor burden within 8 weeks (or 50% within 4 weeks) of initiating ICI and associated with clinical deterioration
Patient must not have any of the following criteria due to the possibility of increased risk for tumor bleeding with bevacizumab therapy:
- Prior carotid bleeding,
- Tumors that invade major vessels (e.g., the carotid) as shown unequivocally by imaging studies,
- Central (e.g., within 2 cm from the hilum) lung metastases that are cavitary as shown unequivocally by imaging studies,
- Any prior history of bleeding related to the current head and neck cancer,
- History of gross hemoptysis (bright red blood of 1/2 teaspoon or more per episode of coughing) within 3 months prior to randomization
- Patient must not have uncontrolled hypertension, a history of hypertensive crisis or hypertensive encephalopathy, or a history of grade 4 thromboembolism
- Patient must not have a history of coagulopathy or hemorrhagic disorders
- Patient must not have a history of thrombosis (e.g., pulmonary embolism or deep venous thrombosis) currently requiring therapeutic anticoagulation (prophylactic use of anticoagulation is allowed)
- Patient must not be receiving chronic daily treatment with aspirin (> 325 mg/day) or non-steroidal anti-inflammatory agents (NSAID's) known to inhibit platelet function. The use of anti-platelet agents [e.g., dipyridamole (Persantine), ticlopidine (Ticlid), clopidogrel (Plavix)] is allowed only if patient is not receiving concurrent aspirin or NSAID's known to inhibit platelet function.
Patient must have PD-L1 expression >= 1% by combined positive score (CPS) in the tumor and/or immune cells
- NOTE: Enrolling centers should test for PD-L1 CPS preferably using the SP263 assay. Where this is not feasible, using their preferred Clinical Laboratory Improvement Act (CLIA)-certified or similar assay will be accepted. It is preferred for standard of care (SOC) PD-L1 assessments to be done on post-first line ICI samples if available, but SOC PD-L1 assessments on pre-ICI samples will be accepted for eligibility
- Patient must not have a severe infection within 4 weeks prior to randomization, including, but not limited to, hospitalization for complications of infection, bacteremia, or severe pneumonia. Patients must not have active tuberculosis
- Patient must not have a history of non-infectious pneumonitis requiring steroids at doses greater than or equal to 10 mg per day of prednisone or the equivalent on first line immunotherapy
- Patient must not have a history of solid organ transplantation or stem-cell transplant
- Patient must not be on immunosuppressive medication within 7 days prior to randomization except for: intranasal, inhaled, or topical steroids, local steroid injection, systemic corticosteroids at doses less than or equal to 10 mg per day of prednisone or the equivalent, or steroids used as premedication for hypersensitivity reactions
- Patient must not have an active autoimmune disease that requires systemic treatment within 2 years prior to randomization. Patients who are receiving replacement therapy for adrenal or pituitary insufficiency will not be excluded
- Patient must not have had a severe hypersensitivity reaction to any of the drug components used on this protocol or to chimeric or humanized antibodies or fusion proteins
- Patient must not have received any live vaccine within 30 days prior to randomization and while participating in the study (and continue for 5 months after the last dose of atezolizumab on Arm C). Live vaccines include, but are not limited to, the following: measles, mumps, rubella, chicken pox, yellow fever, rabies, bacillus Calmette-Guerin (BCG), and typhoid (oral) vaccine. Patients are permitted to receive inactivated vaccines and any non-live vaccines including those for the seasonal influenza and coronavirus disease 2019 (COVID-19) (Note: intranasal influenza vaccines, such as Flu-Mist (registered trademark) are live attenuated vaccines and are not allowed). If possible, it is recommended to separate study drug administration from vaccine administration by about a week (primarily, in order to minimize an overlap of adverse events
Patient must not be pregnant or breast-feeding due to the potential harm to an unborn fetus and possible risk for adverse events in nursing infants with the treatment regimens being used.
- All patients of childbearing potential must have a blood test or urine study within 14 days prior to randomization to rule out pregnancy.
- A patient of childbearing potential is defined as anyone, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 3) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)
Patients must not expect to conceive or father children by using accepted and effective method(s) of contraception or by abstaining from sexual intercourse for the duration of their participation in the study and for 2 months after the last dose of treatment for patients assigned to Arm A and for 6 months after the last dose of protocol treatment for patients assigned to Arms B or C.
- NOTE: Patients must also not breastfeed while on treatment and for 2 months after the last dose of treatment for patients assigned to Arm A and for 6 months after the last dose of treatment for patients assigned to Arms B or C
- Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible
- Leukocytes >= 3,000/mcL (must be obtained =< 14 days prior to protocol randomization)
- Absolute neutrophil count (ANC) >= 1,500/mcL (must be obtained =< 14 days prior to protocol randomization)
- Platelets >= 100,000/mcL (must be obtained =< 14 days prior to protocol randomization)
- Hemoglobin (Hgb) > 9 g/dL (must be obtained =< 14 days prior to protocol randomization) (Note: Patient may be transfused to meet this criteria)
- Total bilirubin =< 2.0 x institutional upper limit of normal (ULN) (=< 5.0 x institutional ULN if hepatic metastases present or =< 3 x ULN for patients with known Gilbert's disease) (must be obtained =< 14 days prior to protocol randomization)
- Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (< 5.0 x institutional ULN if hepatic metastases present) (must be obtained =< 14 days prior to protocol randomization)
- Alkaline phosphatase < 2.5 x institutional ULN (< 5.0 x institutional ULN if hepatic or bone metastases present) (must be obtained =< 14 days prior to protocol randomization)
- Creatinine =< 1.5 x institutional ULN (must be obtained =< 14 days prior to protocol randomization)
- Patients with uncontrolled or symptomatic hypercalcemia (ionized calcium > 1.5 mmol/L, calcium > 12 mg/dL or corrected serum calcium > ULN) must have their calcium levels corrected prior to randomization
- Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months of randomization are eligible for this trial
- For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated
- Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load
- Patients with treated brain metastases are eligible if follow-up brain imaging after central nervous system (CNS)-directed therapy shows no evidence of progression. Patients must not have untreated brain metastases or leptomeningeal disease
- Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
- Patients must not have uncontrolled pleural effusion, pericardial effusion, or ascites requiring recurrent drainage procedures (once monthly or more frequently). Patients may have indwelling catheters (e.g., PleurX [registered trademark])
- Patient must not have significant cardiovascular disease (such as New York Heart Association class II or greater cardiac disease, myocardial infarction, or cerebrovascular accident) within 3 months prior to randomization, or unstable arrhythmia or unstable angina at the time of randomization
- Patient must not receive any other chemotherapy, immunotherapy, antitumor hormonal therapy (excluding contraceptives and replacement steroids), radiation therapy, or experimental medications while on protocol treatment. Symptomatic lesions (e.g., bone metastases or metastases causing nerve impingement) amenable to palliative radiotherapy should be treated prior to randomization and patients must be recovered from the effects of radiation (there is no required minimum recovery period
- Patient must not have had a surgical procedure (including open biopsy, surgical resection, wound revision, or any other major surgery involving entry into a body cavity) or significant traumatic injury within 28 days prior to randomization, or anticipation of need for major surgical procedure while on protocol treatment
- Patient must not have any other disease, metabolic dysfunction, physical examination finding, or clinical laboratory finding that contraindicates the use of the agents used in this protocol, may affect the interpretation of the results, or may render the patient at high risk from treatment complications
- Patient must not have a history of abdominal fistula, gastrointestinal (GI) perforation, intra-abdominal abscess, or active GI bleeding within 6 months prior to randomization
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Sequential Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Phase III, Arm B (Chemotherapy, Bevacizumab, Atezolizumab)
Patients receive treatment as in Arm B or C above based on results of the Phase II trial.
|
Given IV
Other Names:
Undergo MRI
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Undergo PET scan
Other Names:
Undergo CT scan
Other Names:
Undergo ECHO
Other Names:
|
Active Comparator: Phase II, Arm A (Cetuximab, Docetaxel, Cisplatin, Carboplatin)
Patients receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle.
Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.
Patients then receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 or days 1 and 15 of each cycle of maintenance therapy.
Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity.
Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial.
Patients may undergo ECHO during screening.
Patients undergo blood sample collection throughout the study.
|
Given IV
Other Names:
Undergo MRI
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Undergo blood sample collection
Other Names:
Undergo PET scan
Other Names:
Undergo CT scan
Other Names:
Undergo ECHO
Other Names:
Given IV
Other Names:
|
Experimental: Phase II, Arm B(Docetaxel, Cisplatin/Carboplatin, Bevacizumab)
Patients receive bevacizumab IV over 30-90 minutes on day 1 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle.
Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.
Patients then receive bevacizumab IV over 30-60 minutes on day 1 of each cycle of maintenance therapy.
Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity.
Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial.
Patients may undergo ECHO during screening.
Patients undergo blood sample collection throughout the study.
|
Given IV
Other Names:
Undergo MRI
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Undergo blood sample collection
Other Names:
Given IV
Other Names:
Undergo PET scan
Other Names:
Undergo CT scan
Other Names:
Undergo ECHO
Other Names:
|
Experimental: Phase II, Arm C (Bevacizumab, Atezolizumab)
Patients receive bevacizumab IV over 30-90 minutes on day 1 and atezolizumab over 30-60 minutes on day 1 of each cycle.
Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity.
Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial.
Patients may undergo ECHO during screening.
Patients undergo blood sample collection throughout the study.
|
Undergo MRI
Other Names:
Undergo blood sample collection
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Undergo PET scan
Other Names:
Undergo CT scan
Other Names:
Undergo ECHO
Other Names:
|
Experimental: Phase III, Arm A (Cetuximab, Docetaxel, Cisplatin/Carboplatin)
Patients receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 of each cycle, docetaxel IV over 1 hour on day 1 or days 1 and 8 of each cycle, and cisplatin IV or carboplatin IV on day 1 or days 1 and 8 of each cycle.
Treatment repeats every 21 days for up to 6 cycles in the absence of disease progression or unacceptable toxicity.
Patients then receive cetuximab IV over 60-120 minutes on days 1, 8, and 15 or days 1 and 15 of each cycle of maintenance therapy.
Cycles repeat every 21 days for 2 years in the absence of disease progression or unacceptable toxicity.
Patients undergo a CT scan, a PET scan, and/or MRI throughout the trial.
Patients may undergo ECHO during screening.
Patients undergo blood sample collection throughout the study.
|
Given IV
Other Names:
Undergo MRI
Other Names:
Given IV
Other Names:
Given IV
Other Names:
Undergo blood sample collection
Other Names:
Undergo PET scan
Other Names:
Undergo CT scan
Other Names:
Undergo ECHO
Other Names:
Given IV
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Progression free survival (PFS) (Phase II)
Time Frame: Time from treatment initiation until disease progression or death, assessed up to 5 years from randomization
|
Time from treatment initiation until disease progression or death, assessed up to 5 years from randomization
|
|
Overall survival (OS) (Phase III)
Time Frame: Time from treatment initiation until death from any cause, assessed up to 5 years from randomization
|
Will be compared using a stratified log rank test.
|
Time from treatment initiation until death from any cause, assessed up to 5 years from randomization
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Prediction of treatment response
Time Frame: Baseline up to 12 weeks
|
Determined by 18FDG-PET/CT and CT neck imaging biomarkers.
To determine if 18FDG-PET/CT and CT neck imaging biomarkers at baseline will predict treatment response at nine to twelve weeks post-treatment, PFS, and OS Logistic regression model will be fit to assess the association of the 18F -FDG PET /CT imaging biomarkers (e.g., SUVmax, MTV, TLG, tumor heterogeneity, tumor volume) with binary treatment response at 9-12 weeks post treatment.
Cox proportional hazards models will be fit to assess the association of 18F -FDG PET /CT imaging biomarkers with time-to-event outcomes (PFS or OS).
|
Baseline up to 12 weeks
|
OS in the subset of patients with high PD-L1 expression (Phase III)
Time Frame: Up to 5 years from randomization
|
The interaction of PD-L1 by treatment will also be evaluated in a Cox proportional hazards model.
|
Up to 5 years from randomization
|
Incidence of adverse events (Phase III)
Time Frame: Up to 30 days after completion of treatment
|
Up to 30 days after completion of treatment
|
|
Correlation between fludeoxyglucose F-18 (18F-FDG) positron emission tomography (PET) and computed tomography (CT) neck imaging biomarkers
Time Frame: Up to 5 years from randomization
|
The two-sample t-test will be used to compare the difference of baseline 18F -FDG PET /CT imaging biomarkers (maximum standardized uptake value [SUVmax], metabolic tumor volume [MTV], total lesion glycolysis [TLG], tumor volume) between low and high expression of PD-L1.
|
Up to 5 years from randomization
|
Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Correlation between 18F-FDG PET and CT neck radiomics features and expression of PD-L1 expression
Time Frame: Up to 5 years from randomization
|
The imaging textural features from radiomics analysis will be associated with the dichotomized PD-L1 expressions.
First, proper transformation will be applied to the textural features as needed to address the distribution skewness.
Second, Pearson or Spearman rank correlations will be calculated between all pairs of textural features to identify highly correlated features.
Third, to address overfitting and high collinearity, machine learning techniques (e.g., LASSO or XGBoost) will be employed for feature selection during the association analysis with PD-L1 expressions.
|
Up to 5 years from randomization
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Aarti Bhatia, ECOG-ACRIN Cancer Research Group
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Respiratory Tract Diseases
- Neoplasms by Histologic Type
- Neoplasms
- Neoplasms by Site
- Neoplasms, Glandular and Epithelial
- Disease Attributes
- Respiratory Tract Neoplasms
- Pharyngeal Neoplasms
- Otorhinolaryngologic Neoplasms
- Nasopharyngeal Diseases
- Pharyngeal Diseases
- Stomatognathic Diseases
- Otorhinolaryngologic Diseases
- Mouth Diseases
- Neoplasms, Squamous Cell
- Nasopharyngeal Neoplasms
- Laryngeal Diseases
- Head and Neck Neoplasms
- Carcinoma
- Nasopharyngeal Carcinoma
- Recurrence
- Carcinoma, Squamous Cell
- Squamous Cell Carcinoma of Head and Neck
- Mouth Neoplasms
- Laryngeal Neoplasms
- Physiological Effects of Drugs
- Molecular Mechanisms of Pharmacological Action
- Antineoplastic Agents
- Immunologic Factors
- Tubulin Modulators
- Antimitotic Agents
- Mitosis Modulators
- Angiogenesis Inhibitors
- Angiogenesis Modulating Agents
- Growth Substances
- Growth Inhibitors
- Immune Checkpoint Inhibitors
- Docetaxel
- Carboplatin
- Antibodies
- Cisplatin
- Immunoglobulins
- Bevacizumab
- Antibodies, Monoclonal
- Antineoplastic Agents, Immunological
- Cetuximab
- Atezolizumab
- Immunoglobulin G
- Endothelial Growth Factors
Other Study ID Numbers
- NCI-2021-10021 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180820 (U.S. NIH Grant/Contract)
- EA3202 (Other Identifier: CTEP)
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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