- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05324904
Intralesional Vitamin D3 Versus Intralesional Acyclovir in Treatment of Plantar Warts
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Introduction Warts are common epidermal growths caused by various strains of human papillomavirus (HPV) affecting all age groups. They have an unsightly appearance and are mostly asymptomatic but sometimes may be painful as in the case of palmoplantar warts . Plantar warts is a clinical variant that occur on sole of the foot, most frequently over pressure points .
It is estimated that 40% of population is infected with HPV, and in 7% to 12%, a wart develops . Plantar warts exhibit an annual incidence of 14% in the general population . Sixty-five percent to 78% of cutaneous warts have been shown to regress within 2 years . In persons older than 12 years, the rate of spontaneous regression significantly decreases .
Variable therapeutic options are available for treating warts, with none considered a gold standard. Primary treatments include topical salicylic acid, topical imiquimod, topical 5-fluorouracil, cryotherapy, excision, electrocautry and laser vaporization .
Vitamin D is a fat-soluble steroid prohormone that has wide range of biological actions e.g. inhibition of cellular proliferation, induction of terminal differentiation, and inhibition of angiogenesis. It also stimulates macrophages and cathelicidin production . Recently, several studies have demonstrated the efficacy of intralesional vitamin D in treatment of warts, as well as recalcitrant lesions, with clearance rates of 72.5%-90% .
Acyclovir is a synthetic purine nucleoside analogue with activity against some viruses as herpes simplex and varicella-zoster virus. Acyclovir uses viral thymidine kinase to convert to its active form, acyclovir triphosphate. Through this mechanism of utilizing viral thymidine kinase, acyclovir specifically targets viral DNA preventing its replication in the host.
Previously, few studies and case reports documented the clearance of warts, some were unresponsive to prior treatment, with both topical and oral use of acyclovir .
A recent study has evaluated the efficacy of intralesional acyclovir versus intralesional saline in treatment of warts and reported complete clearance rate of 52.6% and a partial response of 16.7% for acyclovir with a statistically significant difference from saline (0% complete clearance) .
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: maha m mostafa, MD
- Phone Number: a +201158597040
- Email: mahamostafaali@yahoo.com
Study Contact Backup
- Name: maha m mostafa, MD
- Phone Number: a 01158597040
- Email: mahamostafaali@yahoo.com
Study Locations
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Assiut, Egypt
- Assuit University
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Adult participants of both sex with plantar warts will be included in the study
Exclusion Criteria:
- - Children < 12 years.
- Pregnant and lactating women.
- Receiving any treatment for warts within 1 month before the study.
- Systemic antiviral medication.
- Previous history of vitamin D or acyclovir hypersensitivity.
- Vitamin D supplementation.
- Concurrent other skin disorders.
- Immunosuppressive disorders or receiving immunosuppressive drugs.
- Receiving drugs that may alter vitamin D level including prednisone, orlistat, phenytoin and thiazide diuretics.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Double
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: group 1
this group will be intralesionaly injected with vitamin D3
|
- Vitamin D
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Active Comparator: group 2
this group will be intralesionally injected with acyclovir
|
-Acyclovir
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
complete healing rate
Time Frame: 12 weeks
|
Main outcome variable is the complete healing rate among planter warts patients treated with intralesional vitamin D3 compared to those by Intralesional acyclovir
|
12 weeks
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: maha m mostafa, MD, Assuit University Faculty of Medicine
Study record dates
Study Major Dates
Study Start (Anticipated)
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Skin Diseases
- Virus Diseases
- Infections
- Musculoskeletal Diseases
- DNA Virus Infections
- Skin Diseases, Infectious
- Papillomavirus Infections
- Skin Diseases, Viral
- Tumor Virus Infections
- Warts
- Foot Diseases
- Physiological Effects of Drugs
- Anti-Infective Agents
- Antiviral Agents
- Micronutrients
- Vitamins
- Bone Density Conservation Agents
- Vitamin D
- Acyclovir
Other Study ID Numbers
- vitamin D3, acyclovir in warts
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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