Balneotherapy for Patients With Post-acute Coronavirus Disease (COVID) Syndrome

Effects of Balneotherapy for Patients With Post-COVID Syndrome

The goal of this randomized controlled study is to evaluate the effects of balneotherapy (BT) and aquatic exercises in patients with post-acute COVID syndrome (PACS). The main question it aims to answer are:

• Does BT and aquatic exercises alleviate some of the most prevalent features that characterize post-acute COVID syndrome?

Participants allocated to the intervention group will undergo 3 weekly sessions of BT and aquatic exercises on alternate days in groups of 8 during 4 weeks. Prior the beginning of the intervention, patients were asked to complete an array of validated self-reported questionnaires that covered an important part of PACS symptomatology. These patients were asked to complete these same questionnaires immediately after completing the intervention and one month after. They were also asked to report adverse events associated to the intervention.

Patients allocated to the control group were asked to complete the same questionnaires at baseline and one and two months post-baseline. They were instructed to not enroll in any kind of BT-related activities during the duration of the study.

Questionnaires were analyzed and compared between groups to assess the effects of the intervention.

Study Overview

• Status: Completed
• Conditions: Post-COVID-19 Syndrome
• Intervention / Treatment: Other: Balneotherapy and aquatic exercises

Detailed Description

Participants were recruited in the multidisciplinary Post-COVID unit of the Hospital del Mar or in a primary care center in Barcelona (Spain). In addition, Caldes de Montbui's City Council also advertised the project for patient recruitment on its public website. Inclusion criteria were individuals ≥18 years old with a PACS diagnosis provided by a physician.

Exclusion criteria included patients with preexisting disorders to the severe acute respiratory syndrome (SARS) coronavirus (CoV) 2 infection that displayed an important clinical overlap with PACS i.e., fibromyalgia (FM), chronic fatigue syndrome, chronic pain, and generalized anxiety disorder and/or depression that required pharmacological treatment. Patients with chronic debilitating conditions that required active treatment were also excluded i.e. cancer, chronic viral infections, systemic autoimmune diseases, epilepsy, uncontrolled endocrine disorders, etc. Patients with fear of water, incontinence, severe venous insufficiency, physical disabilities that hindered performance of Balneotherapy (BT)/aquatic exercises, and those who reported a tendency for symptomatic low blood pressure were also excluded. Blood tests performed within 4 months or less before the initial visit were mandatory for preselection and were reviewed: patients with anaemia, chronic kidney disease (CKD) stage 4 or less, chronic liver insufficiency, thyroid function abnormalities, and in general, any significant blood test abnormality that could be associated with PACS-related symptomatology were excluded.

Included patients underwent initial visit in which clinical data was reviewed and registered. Participants were randomly assigned to the intervention or control group through a lottery method. Patients were asked to not vary their usual care or initiate any other kind of therapy during the duration of the study. Post-Acute COVID symptoms At the time of the initial visit several clinical parameters were registered including: age, sex Body Mass Index (BMI), date of SARS-CoV-2 infection, admission into the Intensive Care Unit (yes/no), Visual Analogue Scale (VAS), and a large array of PACS-related symptoms(yes/no) that were classified according to the system/organ affected

Study design The study was designed as a prospective randomized controlled study. Data was collected at 3 time points: 1) initial visit (baseline), 2) at the end of BT or one month after baseline in control group, and 3) one month after BT finalization or two months after baseline in control group. Balneotherapy (BT) intervention The BT intervention consisted of 3 weekly sessions on alternate days in groups of 8 during 4 weeks, i.e., 12 sessions in total. The weekly planning was structured as following:

1 st day: Pool, shower, inhalation and aquatic exercise 2 nd day: Pool, shower, inhalation. 3 rd day: Pool, shower, inhalation and aquatic exercise The exercise program was designed by qualified specialists from the Caldes de Montbui spa. Exercises were performed in the thermal water pool, at 32°C during 2 hours. At the start of the session, patients were instructed to inhale thermal water vapor for 10 minutes, alternating between nose and mouth. Subsequently they underwent a circular shower during 10 minutes with a very fine jet that ran from the ankles to the neck to activate circulation. The temperature of the water and the power of the jet was set by the patient.

Next, they started the exercise program which lasted 15 minutes and was structured as follows:

1. Ankle joints workout, knee flexions, and abductors workout.
2. Waist and arm rotation.
3. Arm raise exercises: arms were raised and lowered from legs to mid-waist. Subsequently, the same exercise was repeated but raising concomitantly knees and, if possible, clapping hands above the head.
4. Hand exercises: patients were instructed to open and close their hands first, and then, repeated the same exercise but alternating hiding or exposing their thumbs.
5. Lateral neck movements.
6. Cycling and rowing movements while holding onto the pool's wall.
7. Walking 2 laps around the pool. During the last 15-20 minutes patients were allowed to relax in the whirlpool.

Control group Patients from the control group were instructed to not participate in any BT-related activity during the duration of the study and to continue with usual care and activities.

Primary Outcome To evaluate the effects of BT we employed an array of validated self-reported questionnaires that covered an important part of PACS symptomatology. The primary outcome of the study was to evaluate differences in questionnaire scores from baseline between both groups. The following scales and questionnaires were employed:

1. Post-COVID-19 functional status scale (PCFS)
2. Modified Medical Research Council (mMRC) Dyspnoea Scale
3. Short Form-36 Health Survey (SF-36) to evaluate generic health-related quality of life (HRQL)
4. Pittsburgh Sleep Quality Index (PSQI)
5. Hospital Anxiety and Depression Scale (HADS)
6. Memory failures in everyday life following severe head injury (MFE-30)
7. Visual Analogic Scale (VAS) Secondary outcomes The percentage of individuals within each group that showed any improvement in the questionnaires' scores at timepoints 2 and 3 compared to baseline were also calculated and compared between groups.

Statistical methods Descriptive statistics were used for demographic and clinical characteristics related to PACS. Comparisons between groups for quantitative variables were performed by t-test and chi-square tests were used for qualitative variables. Questionnaire scores were analysed using the intra-individual absolute change between baseline and post-BT or one month after baseline (control group), and between baseline and one month after completing BT or two months after baseline (control group). One-way ANOVA or chi-square were used for comparisons between groups. The change between time points was also categorized according to whether score improvement was observed (yes/no).

Chi-square test was used to perform the corresponding comparisons between groups.

Finally, univariate General Linear Model (GLM) or multinomial logistic regression were used for group comparisons adjusted by age and BMI. Statistical analysis was done with Statistical Package for the Social Sciences (SPSS) Statistics version 22.0. P values lower than 0.05 were considered significant.

• Study Type: Interventional
• Enrollment (Actual): 98
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Spain
  • Barcelona, Spain, 08003
    • Hospital del Mar Medical Research Institute

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Individuals ≥18 years old with a post-acute COVID-19 syndrome diagnosis provided by a physician.

Exclusion Criteria:

• Patients with preexisting disorders to the acute SARS-CoV-2 infection that displayed an important clinical overlap with PACS i.e., fibromyalgia (FM), chronic fatigue syndrome, chronic pain, and generalized anxiety disorder and/or depression that required pharmacological treatment. Patients with chronic debilitating conditions that required active treatment were also excluded i.e. cancer, chronic viral infections, systemic autoimmune diseases, epilepsy, uncontrolled endocrine disorders, etc. Patients with fear of water, incontinence, severe venous insufficiency, physical disabilities that hindered performance of balneotherapy/aquatic exercises, and those who reported a tendency for symptomatic low blood pressure were also excluded.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Balneotherapy group; The patients allocated to the Balneotherapy group were subject to 3 weekly sessions of Balneotherapy together with an structured program of aquatic exercises on alternate days in groups of 8 during 4 weeks. The weekly planning was structured as following: st day: Pool, shower, inhalation and aquatic exercises; nd day: Pool, shower, inhalation.; rd day: Pool, shower, inhalation and aquatic exercises	Other: Balneotherapy and aquatic exercises; Information has already been included in arm/group descriptions
No Intervention: Control group; Patients from the control group were instructed to not participate in any BT-related activity during the duration of the study and to continue with usual care and activities

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Differences in questionnaire scores in follow-up time points compared to baseline between both groups	To evaluate the effects of BT we employed an array of validated self-reported questionnaires that covered an important part of PACS symptomatology. The primary outcome of the study was to evaluate differences in questionnaire scores from baseline between both groups. The following scales and questionnaires were employed: Post-COVID-19 functional status scale (PCFS); mMRC (Modified Medical Research Council) Dyspnoea Scale; Short Form-36 Health Survey (SF-36); Pittsburgh Sleep Quality Index (PSQI); Hospital Anxiety and Depression Scale (HADS); Memory failures in everyday life following severe head injury (MFE-30); Visual Analogic Scale (VAS)	2 months i.e., baseline, post-balneotherapy (or one month post-baseline in the control group), and 1 month post-balneotherapy (or 2 months post-baseline in the control group)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Differences in the percentage of individuals within each group that showed any improvement in the questionnaires' scores at follow-up time-points compared to baseline	Differences in the percentage of individuals within each group that showed any improvement in the questionnaires' scores at follow-up time-points compared to baseline. The following scales and questionnaires were employed: Post-COVID-19 functional status scale (PCFS); mMRC (Modified Medical Research Council) Dyspnoea Scale; Short Form-36 Health Survey (SF-36); Pittsburgh Sleep Quality Index (PSQI); Hospital Anxiety and Depression Scale (HADS); Memory failures in everyday life following severe head injury (MFE-30); Visual Analogic Scale (VAS)	2 months i.e., baseline, post-balneotherapy (or one month post-baseline in the control group), and 1 month post-balneotherapy (or 2 months post-baseline in the control group)

Collaborators and Investigators

• Sponsor: Parc de Salut Mar
• Collaborators: European Regional Development Fund; Consorcio Centro de Investigación Biomédica en Red (CIBER); Caldes de Montbui's City Council

Study record dates

Study Major Dates

• Study Start (Actual): March 29, 2022
• Primary Completion (Actual): October 29, 2022
• Study Completion (Actual): January 31, 2023

Study Registration Dates

• First Submitted: March 9, 2023
• First Submitted That Met QC Criteria: March 9, 2023
• First Posted (Actual): March 13, 2023

Study Record Updates

• Last Update Posted (Actual): March 13, 2023
• Last Update Submitted That Met QC Criteria: March 9, 2023
• Last Verified: March 1, 2023

More Information

Terms related to this study

• Keywords: Post-COVID-19 syndrome; Patient Reported Outcome Measures; Balneotherapy
• Additional Relevant MeSH Terms: Pathologic Processes; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Infections; Respiratory Tract Infections; Respiratory Tract Diseases; Pneumonia, Viral; Pneumonia; Lung Diseases; Disease; COVID-19; Syndrome
• Other Study ID Numbers: 2021/10072/I

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: This is a closed study and there is no plan to share individual participant data.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No