- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05824013
Blood Coagulation Profile After Liver Resection.
Blood Caogulation Profile After Liver Resection. Comparison of Conventional Blood Coagulation Tests With Thromboelastography
Liver resection is the treatment of choice in patients with primary or metastatic liver neoplasms, benign liver neoplasms and numerous biliary diseases. In these patients, in the postoperative period,several factors can induce a transient alteration of the synthesis hepatic coagulation factors such as size of the lesion liver, underlying liver disease (e.g. malignancy), pre-existing cirrhosis, duration of both surgery and vascular clamping, and blood loss. So far, some studies have shown that conventional coagulation tests indicate a hypocoagulable state which may lead to excessive transfusions of blood products or an increased risk of thromboembolic events related to delayed initiation of thromboprophylaxis in the postoperative period. In an attempt to optimizing the state of coagulation, recently there is increased interest for viscoelastic coagulation testing (thromboelastography and rotational thromboelastometry). The results of these studies have shown that these patients often have a hypercoagulable and non hypocoagulable profile as evidenced by conventional coagulation tests.
the purpose of the study is to evaluate whether the combination of coagulation tests conventional systems and new thromboelastography can increase the quality of surveillance of the coagulation state after liver surgery, in order to optimize the management of postoperative blood coagulation of these patients.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Contacts and Locations
Study Contact
- Name: rita rg gaspari, MD
- Phone Number: +390630153134
- Email: rita.gaspari@policlinicogemelli.it
Study Locations
-
-
-
Roma, Italy, 00168
- Fondazione Policlinico Universitario A. Gemelli IRCCS
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Elective liver resection surgery for liver cancer primary or metastatic
- Admission to surgical intensive care unit at the end of the surgery.
Exclusion Criteria:
- Renal disease (creatinine clearance < 30 ml/min)
- pregnancy
- Benign liver disease
- Emergency surgery
- Reintervention
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
blood coagulation profile
Time Frame: 12 hours
|
Evaluate whether to use TEG®6s, in addition to coagulation tests conventional, optimizes the postoperative hemocoagulation management of patients undergoing resective liver surgery in terms of consumption transfusion of plasma and blood products.
|
12 hours
|
Collaborators and Investigators
Publications and helpful links
General Publications
- Ardito F, Vellone M, Barbaro B, Grande G, Clemente G, Giovannini I, Federico B, Bonomo L, Nuzzo G, Giuliante F. Right and extended-right hepatectomies for unilobar colorectal metastases: impact of portal vein embolization on long-term outcome and liver recurrence. Surgery. 2013 Jun;153(6):801-10. doi: 10.1016/j.surg.2013.02.001.
- Dumitrescu G, Januszkiewicz A, Agren A, Magnusson M, Isaksson B, Wernerman J. The temporal pattern of postoperative coagulation status in patients undergoing major liver surgery. Thromb Res. 2015 Aug;136(2):402-7. doi: 10.1016/j.thromres.2015.05.023. Epub 2015 May 24.
- Blasi A, Molina V, Sanchez-Cabus S, Balust J, Garcia-Valdecasas JC, Taura P. Prediction of thromboembolic complications after liver resection for cholangiocarcinoma: is there a place for thromboelastometry? Blood Coagul Fibrinolysis. 2018 Jan;29(1):61-66. doi: 10.1097/MBC.0000000000000672.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 5492
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Coagulation Disorder
-
Meir Medical CenterUnknownCoagulation Disorder | Blood Coagulation Disorder | Blood Clot | Anticoagulants; Increased | Anticoagulant Overdosage
-
University Hospital, CaenUnknownBlood Coagulation Disorders | Blood Coagulation Disorder With Prolonged Bleeding Time | Blood Coagulation Disorder With Prolonged Coagulation TimeFrance
-
VarmX B.V.RecruitingCoagulation DisorderNetherlands
-
Groupe Hospitalier Paris Saint JosephCompletedCoagulation DisorderFrance
-
Cairo UniversityRecruitingCoagulation DisorderEgypt
-
Stony Brook UniversityCompletedCoagulation DisorderUnited States
-
HemoSonics LLCCompleted
-
Masaryk Hospital Krajská zdravotní a.s.CompletedCoagulation Disorder | Multiple Trauma | Coagulation Defect; Acquired | Coagulation Factor DeficiencyCzechia
-
TakedaTakeda Development Center Americas, Inc.RecruitingCoagulation DisorderUnited States, Spain, Belgium, France, Netherlands
Clinical Trials on thromboelastography (TEG®6s)
-
Indiana UniversityRecruitingCoagulopathyUnited States
-
The University of Texas Health Science Center,...CompletedIschemic Stroke | Brain HemorrhageUnited States
-
Washington University School of MedicineOrthopedic Research and Education FoundationTerminatedNeuromuscular ScoliosisUnited States
-
Assistance Publique - Hôpitaux de ParisTerminatedCardiopulmonary BypassFrance
-
University Hospital, MontpellierNot yet recruitingCardiac Surgery | Cardiopulmonary Bypass | CoagulopathyFrance
-
Indonesia UniversityCompleted
-
Boston Children's HospitalNot yet recruitingSurgical Blood Loss | Post Operative Hemorrhage | Surgical Hemorrhage
-
Diagnostica Stago R&DHôpital d'Instruction des armées PercyCompletedBlood Coagulation Disorders | Hemorrhagic Disorders | Trauma | Thrombotic DisordersFrance
-
Policlinico HospitalThe Mediterranean Institute for Transplantation and Advanced Specialized...Completed
-
East and North Hertfordshire NHS TrustUniversity of HertfordshireCompleted