PK Effects of SHR4640 on Repaglinide and Midazolam, and the Impact of SHR4640 on QT Interval

A Clinical Study Evaluating the Pharmacokinetic Effects of SHR4640 on Repaglinide and Midazolam in Healthy Subjects and the Impact of SHR4640 on QT Interval

The purpose of this study is to evaluate the PK effects of SHR4640 tablets on repaglinide and midazolam, as well as the effects of SHR4640 tablets on the QT interval in healthy subjects.

Study Overview

• Status: Completed
• Conditions: Gout and Hyperuricemia
• Intervention / Treatment: Drug: repaglinide; midazolam; SHR4640; Drug: repaglinide; midazolam; SHR4640; SHR4640 placebo; Drug: repaglinide; midazolam; SHR4640 placebo

• Study Type: Interventional
• Enrollment (Actual): 24
• Phase: Phase 1

Contacts and Locations

Study Locations

• China
  • Anhui
    • Hefei, Anhui, China, 300041
      • The Second Hospital of Anhui Medical University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

1. Voluntarily sign the informed consent form before the start of the trial-related activities, and be able to understand the procedures and methods of the trial, and are willing to strictly comply with the clinical trial protocol to complete the trial;
2. Aged 18 to 45 years old (both ends included, subject to the time of signing the informed consent form), male or female;
3. Male weight ≥ 50 kg, female weight ≥ 45 kg, and body mass index (BMI): 19-26 kg/m2 (both ends included);
4. No fertility plan and agree to take non-drug high-efficiency contraceptive measures (see appendix 1 for details) within 28 days from signing the informed consent form to the last administration of the trial drug, and no plans for sperm donation or egg donation.

Exclusion Criteria:

1. Individuals who have a history of smoking within the 3 months before signing the informed consent form (average daily smoking>5 cigarettes) or who cannot stop using any tobacco products during the study period;
2. The average daily intake of alcohol in the three months before signing the informed consent is more than 7 g for women (about 200 ml beer, 70 ml wine or 22 ml low-alcohol liquor) and 14 g for men (about 400 ml beer, 140 ml wine or 45 ml low-alcohol liquor); Those who cannot abstain from alcohol during the trial;
3. Within the first 7 days of randomization, consumed any beverage or food containing grapefruit; Or have eaten any beverages or foods containing methylxanthines, such as coffee, tea, cola, chocolate, etc., within the previous 2 days at random;
4. Allergic constitution, or allergic or suspected allergic to SHR4640 tablets, repaglinide or midazolam;
5. Drug abusers, or those who have positive urinary abuse during screening;
6. any history of severe clinical disease or conditions that the researcher believes may affect the results of the trial, including but not limited to the history of circulatory, endocrine, nervous, digestive, urinary, or blood, immune, psychiatric, and metabolic diseases;
7. Patients with contraindication of repaglinide (type 1 diabetes, C-peptide negative diabetes patients, diabetes ketoacidosis patients with or without coma);
8. Patients with contraindications to midazolam (acute angle closure glaucoma, severe respiratory insufficiency, sleep apnea syndrome, myasthenia gravis, schizophrenia, and severe depressive state);
9. During screening, vital signs, physical examinations, laboratory tests, cardiac ultrasound, abdominal ultrasound, or chest imaging examinations indicate the presence of abnormalities that are clinically significant according to the judgment of the investigator;
10. When screening, ultrasound examination of the urinary system indicates the presence of stones or crystals in the urinary system;
11. Individuals with acute kidney injury before screening or random ;
12. Individuals with serum uric acid higher than 420 μmol/L at screening, , or a history of hyperuricemia and/or gout disease;
13. Individuals with QTcF>450 ms, PR interval>200 ms, QRS complex time limit>120 ms, or HR>100 bpm, or other abnormalities that were clinically significant as determined by the researcher;
14. Individuals with risk factors for torsade de pointe ventricular tachycardia, such as heart failure, hypokalemia, short QT syndrome, long QT syndrome, or a first-degree relatives family history of unexplained sudden death, drowning, or sudden infant death syndrome in young adulthood (≤ 40 years old);
15. Individuals with positive hepatitis B surface antigen (HBsAg), or anti-hepatitis C virus (HCV) antibodies, or human immunodeficiency virus (HIV) antibodies, or syphilis antibodies during screening;
16. Individuals who have used any prescription drugs, over-the-counter drugs, herbal medicines, or dietary supplements within two weeks before randomization;
17. Systemic treatment with cytochrome P450 3A4 enzyme (CYP3A4), CYP2C8 inhibitor or inducer drugs used within the first 4 weeks of randomization ;
18. Individuals (excluding screening failures) who have participated in any other drug or medical device clinical trials within 3 months before randomization or within 5 half-lives of the trial drug (whichever is longer);
19. Individuals who have undergone any surgery within three months before randomization, or have not recovered after surgery, or plan to undergo surgery during the trial;
20. Individuals who have donated (or lost) blood within three months before randomization and the amount of blood donated (or lost) is ≥400 mL, or received blood transfusion;
21. According to the judgment of the researchers, subjects with conditions that affect drug absorption, distribution, metabolism, and excretion, or other factors that are not suitable for participation in the study.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: SHR4640 group A	Drug: repaglinide; midazolam; SHR4640; repaglinide; midazolam; SHR4640
Experimental: SHR4640 group B	Drug: repaglinide; midazolam; SHR4640; SHR4640 placebo; repaglinide; midazolam; SHR4640; SHR4640 placebo
Placebo Comparator: SHR4640 Placebo	Drug: repaglinide; midazolam; SHR4640 placebo; repaglinide; midazolam; SHR4640 placebo

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
The plasma PK parameters of repaglinide, midazolam, and SHR4640 in combination: Cmax	Day 1 to Day 24
The plasma PK parameters of repaglinide, midazolam, and SHR4640 in combination: AUC0-t	Day 1 to Day 24
The plasma PK parameters of repaglinide, midazolam, and SHR4640 in combination: AUC0-inf	Day 1 to Day 24
QTcF corrected for baseline and placebo after oral administration of SHR4640 tablets（ ΔΔ QTcF）	Day 1 to Day 24

Secondary Outcome Measures

Outcome Measure	Time Frame
The plasma PK parameters of repaglinide, midazolam, and SHR4640 in combination: Tmax	Day 1 to Day 24
The plasma PK parameters of repaglinide, midazolam, and SHR4640 in combination: t1/2	Day 1 to Day 24
The plasma PK parameters of repaglinide, midazolam, and SHR4640 in combination: CL/F	Day 1 to Day 24
The plasma PK parameters of repaglinide, midazolam, and SHR4640 in combination: Vz/F	Day 1 to Day 24
PK parameters for oral SHR4640 tablets: Cmax	Day 1 to Day 24
PK parameters for oral SHR4640 tablets: AUC0-t	Day 1 to Day 24
PK parameters for oral SHR4640 tablets: Tmax	Day 1 to Day 24
Safety indicators: adverse events	Screening period up to Day 28

Collaborators and Investigators

• Sponsor: Jiangsu HengRui Medicine Co., Ltd.

Study record dates

Study Major Dates

• Study Start (Actual): January 4, 2024
• Primary Completion (Actual): February 16, 2024
• Study Completion (Actual): February 16, 2024

Study Registration Dates

• First Submitted: December 24, 2023
• First Submitted That Met QC Criteria: December 24, 2023
• First Posted (Actual): January 9, 2024

Study Record Updates

• Last Update Posted (Estimated): March 6, 2024
• Last Update Submitted That Met QC Criteria: March 5, 2024
• Last Verified: March 1, 2024

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Hyperuricemia; Hypoglycemic Agents; Physiological Effects of Drugs; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Central Nervous System Depressants; Anesthetics, Intravenous; Anesthetics, General; Anesthetics; Tranquilizing Agents; Psychotropic Drugs; Hypnotics and Sedatives; Adjuvants, Anesthesia; Anti-Anxiety Agents; GABA Modulators; GABA Agents; Midazolam; Repaglinide
• Other Study ID Numbers: SHR4640-113

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No