- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06235385
European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study (EACVI-MMVD)
Study Overview
Status
Conditions
- Aortic Valve Stenosis
- Aortic Valve Disease
- Heart Valve Diseases
- Mitral Valve Insufficiency
- Aortic Valve Insufficiency
- Mitral Valve Stenosis
- Aortic Valve Stenosis With Insufficiency
- Tricuspid Valve Insufficiency
- Mitral Valve Disease
- Tricuspid Valve Disease
- Mitral Valve Insufficiency and Aortic Valve Insufficiency
- Multiple Valve Disease, Unspecified
- Mitral Valve Disease Mixed
- Tricuspid Stenosis
Intervention / Treatment
Detailed Description
Multiple and mixed valvular heart disease (MMVD), ie, the combination of stenotic or regurgitant lesions occurring on ≥2 cardiac valves (multiple valvular heart disease (VHD)) or the combination of stenotic and regurgitant lesions on the same valve (mixed VHD), are frequent in clinical routine. Nevertheless, their clinical, biological, cardiovascular imaging, and management is not well established.
This study will assess the proportion of MMVD including each combination of multiple and mixed VHD in a multicentre registry of all consecutive patients assessed on a cardiovascular imaging department for VHD. Furthermore, as secondary aims, baseline characteristics, decision-making and therapeutic strategy at baseline and their impact in terms of prognostic.
This is a prospective multicentre observational study involving 174 centres worldwide (35 countries) conducted as a cohort study with a 1-year follow-up (with possible extension to 5 years). Consecutive patients with a diagnosis of MMVD by echocardiography who meet the inclusion criteria will be included during the 6 months period of recruitment. In the context of a "real-life" cohort, baseline evaluation will be left to the discretion of the attending physician (and could encompass clinical evaluations, biomarkers, electrocardiograms, transthoracic and transoesophageal echocardiography, stress echocardiography, cardiac catheterization, invasive angiography, cardiac CT, and Cardiac MRI). Final diagnosis of the physician will be given, and physician will manage the patient in accordance with international guidelines (transcatheter valve intervention, surgery or no intervention). One year follow-up will be performed during a patient visit or by contact with the treating physician or the patient: vital status, hospitalizations for cardiac reasons (including heart failure), history of stroke and the performance of a new valvular intervention.
The primary endpoint will be the proportion of MMVD among all patients admitted for VHD evaluation in the imaging department. Secondary endpoints encompass; (i) epidemiologic distribution of clinical, biological, and cardiovascular imaging characteristics at baseline. (ii) proportion of MMVD treated by surgery, percutaneous or medical as well as the detail for management and how complication are managed (iii) prognostic evaluation at one year of follow-up in terms of clinical composite outcome (cardiovascular mortality, hospitalization for heart failure, myocardial infarction, pulmonary embolism and stroke), all-cause mortality, hospitalisation for heart failure, and change in echocardiographic parameters.
This is the first prospective multicentre study assessing the proportion of MMVD and their characteristics in term of diagnosis, management, and prognostic.
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Théo PEZEL, MD PhD
- Phone Number: +33 668722489
- Email: theo.pezel@aphp.fr
Study Contact Backup
- Name: Alexandre UNGER, MD
- Phone Number: +32 478487691
- Email: alexandre.unger@ulb.be
Study Locations
-
-
Île De France
-
Paris, Île De France, France, 75010
- Assistance Publique Hopitaux de Paris
-
Contact:
- Théo PEZEL, MD PhD
- Phone Number: +33 668722489
- Email: theo.pezel@aphp.fr
-
Contact:
- Alexandre UNGER, MD
- Phone Number: +32 478487691
- Email: alexandre.unger@ulb.be
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Age ≥ 18 years
- Patient referred to the cardiovascular imaging department.
Diagnosis of MMVD confirmed by transthoracic echocardiography, defined as:
Multiple VHD: at least 2 moderates to severe VHD involving ≥ 2 different valves, using the current ESC guidelines.
and/or
- Mixed VHD: at least moderate stenosis and at least moderate regurgitation of a single valve, using the current ESC guidelines.
- Patient not refusing to have their data involved in the protocol after information.
Exclusion Criteria (patients fulfilling any of the following criteria are not eligible for inclusion in this study):
- History of prior valve surgery or percutaneous valve intervention (concerning a valve other than those involved in the definition of MMVD).
- Acute infective endocarditis at the time of evaluation for inclusion (confirmed according to modified Duke criteria) or history of endocarditis ≤ 6 months.
- Complex congenital heart diseases.
Study Plan
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Proportion of multiple and mixed valvular disease (MMVD)
Time Frame: Baseline
|
Number of consecutive patients diagnosed with multiple and mixed valvular disease divided by the total number of consecutive patients assessed for valvular heart disease on a cardiovascular imaging department
|
Baseline
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Major Adverse Cardiovascular Event (MACE)
Time Frame: Up to 5 years
|
Clinical composite outcome defined as: cardiovascular mortality, hospitalization for heart failure (HF), myocardial infarction, pulmonary embolism and stroke.
|
Up to 5 years
|
All-cause mortality
Time Frame: Up to 5 years
|
The adjudication of all-cause death was performed using the follow-up performed in clinical routine
|
Up to 5 years
|
Cardiovascular mortality
Time Frame: Up to 5 years
|
The adjudication of cardiovascular mortality was performed using the follow-up performed in clinical routine
|
Up to 5 years
|
Hospitalization for heart failure
Time Frame: Up to 5 years
|
Hospitalization for heart failure according to the European Society of Cardiology (ESC) guidelines
|
Up to 5 years
|
Collaborators and Investigators
Collaborators
Study record dates
Study Major Dates
Study Start (Estimated)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimated)
Study Record Updates
Last Update Posted (Estimated)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Heart Diseases
- Cardiovascular Diseases
- Pathological Conditions, Anatomical
- Ventricular Outflow Obstruction
- Aortic Valve Stenosis
- Mitral Valve Insufficiency
- Aortic Valve Insufficiency
- Constriction, Pathologic
- Heart Valve Diseases
- Aortic Valve Disease
- Tricuspid Valve Insufficiency
- Mitral Valve Stenosis
Other Study ID Numbers
- AP-HP : 231784
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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