- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06361706
VR-Enhanced Psychoeducation for Chronic Pain: A Primary Care Pilot Study (REDOCVR)
Desenvolupament i Avaluació de l'Experiència en Realitat Virtual en la Prova Pilot Per a Pacients Amb Dolor Crònic i Sensibilització Central Als Centres d'Atenció Primària de Badalona Serveis Assistencials
This pilot study aims to evaluate the integration of virtual reality (VR) with a psychoeducational program for individuals experiencing chronic pain and central sensitization. Chronic pain significantly hampers daily life, and the condition of central sensitization intensifies this challenge by making the pain more acute. Our research is grounded in the hypothesis that VR, when used to complement conventional psychoeducational methods, can enhance engagement and understanding of pain management strategies, thus potentially improving patient outcomes.
Key objectives and related measured variables include:
Usability and Feasibility: Evaluated through the System Usability Scale (SUS) responses from both participants and healthcare professionals, assessing the ease of use and integration of VR into the psychoeducational program.
Participant Engagement and Program Adherence: Determined by participants' satisfaction with the VR system, using Likert scale questionnaires, and tracked through session attendance and program completion rates.
Impact on Chronic Pain Management and Emotional Well-being: Assessed through changes in the Warwick-Edinburgh Mental Well-being Scale (WEMWBS), and the Hospital Anxiety and Depression Scale (HADS) collected at baseline, post-intervention, and 4-8 weeks follow-up Self-management of Chronic Pain: Monitored through the Central Sensitization Inventory (CSI) and changes in patient functionality and mobility using the EuroQol-5D-5L scale, measured at baseline, post-intervention, and 4-8 weeks follow-up.
Healthcare Professionals' Perceptions: Investigated using SUS scores and qualitative feedback on the applicability and benefits of VR in clinical practice for chronic pain management.
Participants will complete eight 90-minute sessions, engaging with VR to supplement the program's content. This approach aims to provide immersive experiences that deepen the understanding and management of chronic pain. Participant feedback on the VR experience, alongside observed changes in pain management and overall well-being, will be critically examined.
By targeting individuals suffering from chronic pain, this research aims to offer healthcare professionals an innovative tool for enhancing pain management strategies. Integrating VR into psychoeducational content, the study seeks to promote more engaging and effective learning experiences, potentially leading to improved outcomes in chronic pain management.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The REDOCVR study is an innovative initiative to evaluate the adjunctive use of Virtual Reality (VR) within a psychoeducational framework for managing chronic pain and central sensitization. This initiative aims to harness the immersive potential of VR to enhance traditional psychoeducational strategies, thereby providing a more engaging and impactful patient experience.
Study Design Overview:
The study is structured as a prospective, non-randomized pilot intervention spanning September 2023 to December 2025 across select Primary Care Centers within Badalona Serveis Assistencials. Targeting adults with chronic pain, the intervention seeks to determine the feasibility, usability, and preliminary efficacy of incorporating VR into pain management protocols.
Recruitment and Selection Process Initial Information: The Primary Care Team is informed about the study and introduces it to potential participants that they identifiy in their daily clinical work, who are then scheduled for an evaluation through the centers electronic system.
Selection Procedure: Interested candidates are contacted via phone for further selection through a face-to-face recruitment visit, assessing eligibility by the Inclusion and Exclusion Criteria and collecting informed consent along with baseline data.
Data Collection and Analysis Specifics:
Data will be meticulously collected on paper before being digitized for analysis, ensuring a robust process for capturing and analyzing participant responses, feedback, and outcomes. This process underscores the study's commitment to methodological rigor and data integrity.
Ethical Considerations: Detailed information on informed consent, data management, privacy, and confidentiality will be addressed in the ethical considerations section.
Innovative Intervention Approach:
Participants are introduced to VR as a tool for understanding and managing their condition, with sessions designed to align VR experiences with educational content. The program includes 8 weekly sessions, each lasting 90 minutes, with VR experiences embedded into the curriculum to reinforce learning objectives and engage participants in their care process actively.
Technological and Methodological Framework:
The intervention leverages Oculus Quest 2 headsets, chosen for their standalone capability and immersive quality. Custom content developed using Unity software focuses on mindfulness, pain education, and self-management techniques, ensuring that VR sessions are directly relevant to participants' learning and therapeutic goals.
Overview of Sessions The intervention framework consists of 8 weekly, 90-minute sessions conducted in session rooms within healthcare centers. Each session incorporates a dedicated 15-20 minute segment for VR experiences designed to complement the session's theme and objectives.
Recruitment Visit A 30-minute recruitment visit initiates the study process, involving eligibility assessment through anamnesis, detailing the study's scope, and gathering informed consent from participants.
Session Breakdown
- Introduction to VR Begins with an overview presented by healthcare professionals, followed by an introduction to VR technology, including a practical demonstration to acquaint patients with VR, capped with a 15-minute mindfulness technique using VR.
- Pain Neurophysiology and Self-management Techniques Focuses on explaining the neurophysiology of pain and introducing pain self-management techniques, including habit changes. Features an educational video to deepen the acquired knowledge.
- Psychological Aspects of Pain Concentrates on the psychological dimensions of pain, including the gate control theory. Utilizes 360-degree VR videos, controlled by a psychologist with a tablet, explaining techniques for pain awareness and acceptance.
4 & 6: Reeducation of the Central Nervous System (CNS) Through Physical Activity Engages patients in CNS reeducation activities using interactive VR games designed to encourage physical activity in a fun and engaging manner, overseen by a physiotherapist.
5: Psychological Aspects of Pain - Emotions and Thoughts Addresses emotions and thoughts associated with chronic pain through an educational VR session on emotional management techniques.
7: Emotions and Self-esteem Focuses on acceptance, self-esteem, and emotion management, incorporating a VR educational session on compassionate acceptance techniques.
8: Farewell A closing session that reviews covered content and concludes with a final VR session on attentive breathing techniques for relaxation and skill consolidation.
Expected Outcomes and Contributions:
Through a detailed exploration of VR's role in psychoeducation for chronic pain, the REDOCVR study aims to provide valuable insights into how digital health innovations can enhance traditional therapeutic modalities. The findings are anticipated to inform future interventions, guide clinical practice, and contribute to the broader dialogue on integrating technology into patient care.
Study Type
Enrollment (Estimated)
Phase
- Not Applicable
Contacts and Locations
Study Contact
- Name: José Ferrer Costa, MD
- Phone Number: 0034933951779
- Email: jfcosta@bsa.cat
Study Contact Backup
- Name: Nuria Moran Blanco, MD
- Phone Number: 0034934655200
- Email: nmoran15@bsa.cat
Study Locations
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Barcelona
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Badalona, Barcelona, Spain, 08912
- Recruiting
- Primary Care Progrès-Raval
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Sub-Investigator:
- Elena Villabona Lopez, MSc
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Principal Investigator:
- Jose Ferrer Costa, MD
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Sub-Investigator:
- Melanie Rodriguez Belloso, BSc
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Contact:
- José Ferrer Costa, MD
- Phone Number: 0034933951779
- Email: jfcosta@bsa.cat
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Contact:
- Elena Villabona López, MSc
- Phone Number: 0034933890695
- Email: evlopez@bsa.cat
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Badalona, Barcelona, Spain, 08917
- Recruiting
- Primary Care Center Apenins-Montigalà
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Principal Investigator:
- Jose Ferrer Costa, MD
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Sub-Investigator:
- Christian Torrecillas Camacho, BSc
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Sub-Investigator:
- Alexandra Fernandez Brusco, BSc
-
Contact:
- José Ferrer Costa, MD
- Phone Number: 0034933951779
- Email: jfcosta@bsa.cat
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Contact:
- Christian Torrecillas Camacho, BSc
- Phone Number: 0034933951779
- Email: ctcamacho@bsa.cat
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Badalona, Barcelona, Spain
- Recruiting
- Primary Care Center Morera-Pomar
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Principal Investigator:
- Jose Ferrer Costa, MD
-
Sub-Investigator:
- Nuria Moran Blanco, MD
-
Sub-Investigator:
- Laura Villare Urgel, MSc
-
Contact:
- Nuria Moran Blanco, MD
- Phone Number: 0034934655200
- Email: nmoran15@bsa.cat
-
Contact:
- Laura Villares Urgell, MSc
- Phone Number: 0034934655200
- Email: lvurgell@bsa.cat
-
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Description
Inclusion Criteria:
- Patients experiencing chronic pain with elements of central sensitization, emotional discomfort related to pain, kinesiophobia, or inadequate response to prescribed treatments.
- Patients aged 18 years or older assigned to the assigned to Badalona Serveis Assistnecials´ Primary Care.
- Patients capable of providing consent to participate in the study, signing the informed consent form, and responding to the variable-related questions.
Exclusion Criteria:
- Patients with acute pain (less than 3 months)
- Diagnosis of systemic diseases or severe mental disorders, cognitive impairment, vertigo, epilepsy, or significant visual/auditory impairments that prevent the use of VR headsets.
Withdrawal Criteria:
- Presence of VR-related side effects or patient's decision to withdraw.
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Supportive Care
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: VR-Enhanced Chronic Pain Management Program
Participants in this arm will undergo a comprehensive psychoeducational program tailored for chronic pain and central sensitization management, significantly enhanced with Virtual Reality (VR) experiences.
|
Participants undergo eight weekly sessions that include VR to learn pain physiology, mindfulness, and self-management techniques.
Each session is 90 minutes, with 15-20 minutes of VR activities designed to complement the educational content.
Activities simulate pain management exercises and mindfulness meditation.
The program, led by pain management and VR specialists, aims to improve pain management skills, emotional well-being, and quality of life.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Participant Satisfaction with the VR-enhanced Psychoeducational Program as measured by the Participants Satisfaction Questionnaire
Time Frame: Immediately after the last intervention session (within 30 minutes of completing the 8th session)
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The Participant Satisfaction Questionnaire assesses with 10 itens various aspects of the VR-enhanced psychoeducational program, including content relevance, VR experience, and perceived benefits in managing chronic pain.
This questionnaire uses a Likert scale for responses, providing a quantitative measure of participant satisfaction.
The questionnaire's design allows for a comprehensive evaluation of the program's impact on participants, with higher scores indicating greater satisfaction.
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Immediately after the last intervention session (within 30 minutes of completing the 8th session)
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Participants´ System Usability and VR Headset Comfort as assessed by the SUS for participants
Time Frame: Immediately after the last intervention session (within 30 minutes of completing the 8th session)
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The SUS is a two-part Likert Scale with options ranging from "Strongly disagree" to "I quite agree," designed to evaluate both the system's usability and the comfort of the VR headset used.
Participants will respond to 16 statements, with 8 focused on system usability and 8 on headset comfort.
Statements are rated on a scale from 1 to 5. For usability, positive experiences are reflected by statements 1, 3, 4, 6, and 7, while for headset comfort, statements assess aspects like weight, ease of use, and physical discomfort.
The overall SUS score is calculated to assess usability and comfort, with higher scores indicating better usability and comfort levels.
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Immediately after the last intervention session (within 30 minutes of completing the 8th session)
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Professionals System Usability as measured by the SUS for Professionals
Time Frame: Immediately after the last intervention session (within 30 minutes of completing the 8th session)
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The SUS for Professionals is designed to evaluate healthcare professionals' perceptions of the VR system's usability within the clinical setting for this educational program.
This assessment uses a Likert Scale from "Strongly disagree" to "I quite agree," focusing on ease of use, integration into practice, and the system's effectiveness in enhancing patient care.
Higher scores on the SUS for Professionals indicate a positive assessment of the system's usability and potential impact on patient treatment.
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Immediately after the last intervention session (within 30 minutes of completing the 8th session)
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Mental Well-being as assessed by the WEMWBS-7
Time Frame: Baseline and immediately after the last intervention session (within 30 minutes of completing the 8th session)
|
The 7-item Warwick-Edinburgh Mental Well-being Scale (WEMWBS-7) is a concise version designed to efficiently assess mental well-being, focusing predominantly on functioning aspects.
It is characterized by better scaling properties, enhancing the precision of measuring differences in scores.
It has been demonstrated to be responsive to change in clinical populations undergoing psychotherapy at both group and individual levels.
The minimal detectable change at the individual level is calculated as 1 or 3 points, with total scores requiring transformation according to a provided table.
This scale is chosen for its brevity and focus on functioning, making it particularly suited for evaluations where time is constrained but a precise and responsive measure of mental well-being is needed.
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Baseline and immediately after the last intervention session (within 30 minutes of completing the 8th session)
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Anxiety and Depression Severity as measured by the HADS
Time Frame: Baseline and immediately after the last intervention session (within 30 minutes of completing the 8th session)
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The Hospital Anxiety and Depression Scale (HADS) is a self-administered instrument consisting of 14 items divided into two subscales: one for anxiety and one for depression, with interspersed items.
It focuses on anhedonia as a core aspect of the depression subscale, a primary symptom distinguishing depression from anxiety.
Items are scored on a 4-point Likert frequency scale (0-3), with total scores ranging from 0 to 21 for each subscale.
Higher scores indicate greater symptom severity.
Scores above eleven suggest a definitive "case" of anxiety or depression, while scores above eight are considered "probable cases."
The scale's internal consistency for the Spanish population in a fibromyalgia study was α=.83 for anxiety and α=.87 for depression.
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Baseline and immediately after the last intervention session (within 30 minutes of completing the 8th session)
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Central Sensitization as measured by the CSI
Time Frame: Baseline and immediately after the last intervention session (within 30 minutes of completing the 8th session)
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The Central Sensitization Inventory (CSI) is utilized to assess the extent of central sensitization symptoms in participants.
It comprises questions rated on a 5-point scale, from 0 ("never") to 4 ("always"), with the total score achievable being 100.
This summed response quantifies the level of self-reported symptomology related to central sensitization.
Higher CSI scores indicate greater symptom severity, with a score exceeding 40 suggesting the presence of central sensitization.
This measure is critical for identifying participants experiencing heightened sensitivity to pain, a key factor in chronic pain syndromes, and assessing the effectiveness of interventions aimed at managing these symptoms.
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Baseline and immediately after the last intervention session (within 30 minutes of completing the 8th session)
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Changes in Functionality and Mobility as assessed by the EuroQol-5D-5L Scale
Time Frame: Baseline and immediately after the last intervention session (within 30 minutes of completing the 8th session)
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The EuroQol-5D-5L scale measures changes in participants' functionality and mobility.
This assessment covers five dimensions: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression, with a scoring system that highlights the degree of difficulty in each area.
Improvements are indicated by lower scores in dimensions related to pain/discomfort and better scores in mobility and self-care.
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Baseline and immediately after the last intervention session (within 30 minutes of completing the 8th session)
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Adherence to the VR-enhanced Psychoeducational Program as indicated by session attendance and program completion rates
Time Frame: After the last intervention session, up to 16 weeks
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Program adherence is measured by tracking participants' attendance at the sessions and their completion of the entire VR-enhanced psychoeducational program.
High attendance and completion rates are indicators of the program's acceptability and participants' engagement with the VR intervention.
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After the last intervention session, up to 16 weeks
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Participant Feedback as recorded on the Participant Comment Sheet
Time Frame: Immediately at the end of each session
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The Participant Comment Sheet is designed to capture immediate, qualitative feedback from participants at the end of each VR-enhanced psychoeducational session.
This open-ended feedback mechanism allows participants to express their thoughts, experiences, and suggestions regarding the session they just completed.
The comments provide valuable insights into the program's reception, areas for improvement, and the overall impact from the participant's perspective.
Collecting this data after each session enables ongoing evaluation and potential adjustment of the program based on participant feedback, enhancing the relevance and effectiveness of the intervention.
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Immediately at the end of each session
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Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Jose Ferrer Costa, MD, Badalona Serveis Assistencials
Publications and helpful links
General Publications
- Grossman P, Tiefenthaler-Gilmer U, Raysz A, Kesper U. Mindfulness training as an intervention for fibromyalgia: evidence of postintervention and 3-year follow-up benefits in well-being. Psychother Psychosom. 2007;76(4):226-33. doi: 10.1159/000101501.
- Moro C, Stromberga Z, Raikos A, Stirling A. The effectiveness of virtual and augmented reality in health sciences and medical anatomy. Anat Sci Educ. 2017 Nov;10(6):549-559. doi: 10.1002/ase.1696. Epub 2017 Apr 17.
- Brown CA, Jones AK. Psychobiological correlates of improved mental health in patients with musculoskeletal pain after a mindfulness-based pain management program. Clin J Pain. 2013 Mar;29(3):233-44. doi: 10.1097/AJP.0b013e31824c5d9f.
- Ma J, Zhao D, Xu N, Yang J. The effectiveness of immersive virtual reality (VR) based mindfulness training on improvement mental-health in adults: A narrative systematic review. Explore (NY). 2023 May-Jun;19(3):310-318. doi: 10.1016/j.explore.2022.08.001. Epub 2022 Aug 5.
- Yang H, Cai M, Diao Y, Liu R, Liu L, Xiang Q. How does interactive virtual reality enhance learning outcomes via emotional experiences? A structural equation modeling approach. Front Psychol. 2023 Jan 6;13:1081372. doi: 10.3389/fpsyg.2022.1081372. eCollection 2022.
- Barteit S, Lanfermann L, Barnighausen T, Neuhann F, Beiersmann C. Augmented, Mixed, and Virtual Reality-Based Head-Mounted Devices for Medical Education: Systematic Review. JMIR Serious Games. 2021 Jul 8;9(3):e29080. doi: 10.2196/29080.
- Pascual K, Fredman A, Naum A, Patil C, Sikka N. Should Mindfulness for Health Care Workers Go Virtual? A Mindfulness-Based Intervention Using Virtual Reality and Heart Rate Variability in the Emergency Department. Workplace Health Saf. 2023 Apr;71(4):188-194. doi: 10.1177/21650799221123258. Epub 2022 Nov 14.
- Meese MM, O'Hagan EC, Chang TP. Healthcare Provider Stress and Virtual Reality Simulation: A Scoping Review. Simul Healthc. 2021 Aug 1;16(4):268-274. doi: 10.1097/SIH.0000000000000484.
- Tack C. Virtual reality and chronic low back pain. Disabil Rehabil Assist Technol. 2021 Aug;16(6):637-645. doi: 10.1080/17483107.2019.1688399. Epub 2019 Nov 20.
- Goudman L, Jansen J, Billot M, Vets N, De Smedt A, Roulaud M, Rigoard P, Moens M. Virtual Reality Applications in Chronic Pain Management: Systematic Review and Meta-analysis. JMIR Serious Games. 2022 May 10;10(2):e34402. doi: 10.2196/34402.
- Ummels D, Cnockaert E, Timmers I, den Hollander M, Smeets R. Use of Virtual Reality in Interdisciplinary Multimodal Pain Treatment With Insights From Health Care Professionals and Patients: Action Research Study. JMIR Rehabil Assist Technol. 2023 Nov 10;10:e47541. doi: 10.2196/47541.
- de Vries FS, van Dongen RTM, Bertens D. Pain education and pain management skills in virtual reality in the treatment of chronic low back pain: A multiple baseline single-case experimental design. Behav Res Ther. 2023 Mar;162:104257. doi: 10.1016/j.brat.2023.104257. Epub 2023 Jan 18.
- Brown L, DiCenso-Fleming T, Ensign T, Boyd AJ, Monaghan G, Binder DS. Chronic pain education delivered with a virtual reality headset in outpatient physical therapy clinics: a multi-site exploratory trial. Am J Transl Res. 2023 May 15;15(5):3500-3510. eCollection 2023.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- 24/047-P
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
In our study, outcome data initially collected on paper are manually entered into Excel sheets, creating a digitized dataset that reflects the raw results of the research. This digitization process is conducted with precision to ensure accuracy and reliability of the data. The digitalized data are then coded and stored securely within the BSA intranet, in a protected digital folder accessible only to authorized personnel.
Given the manual transcription and internal storage of these data, our plan to share Individual Participant Data (IPD) includes specific steps tailored to maintain data integrity, confidentiality, and compliance with ethical standards:
IPD Sharing Time Frame
IPD Sharing Access Criteria
IPD Sharing Supporting Information Type
- STUDY_PROTOCOL
- SAP
- ICF
- ANALYTIC_CODE
- CSR
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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