- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT01068847
Drug Discrimination in Methadone-Maintained Humans Study 3 (OMDD3)
6. marts 2013 opdateret af: University of Arkansas
This study involves giving psychoactive drugs intramuscularly (injected into the muscle of the upper arm or the hip) and/or orally, and measuring the participant's ability to tell the difference between one drug and another, as well as measuring the effects of the drugs on mood, physiology (e.g., heart rate, blood pressure, respiration rate) and behavior.
Each participant will receive 2-4 of the listed interventions.
Studieoversigt
Status
Afsluttet
Betingelser
Intervention / Behandling
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
9
Fase
- Fase 1
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Arkansas
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Little Rock, Arkansas, Forenede Stater, 72205
- University of Arkansas for Medical Sciences
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 65 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inclusion Criteria:
- Must be between the ages of 18-65.
- Participation in the UAMS Substance Abuse Treatment Clinic Methadone Maintenance Program or the CATAR Clinic Little Rock with maintenance on a stable dose of methadone (+ or - 10 mg) for at least 1 month prior to study entry.
- Subjects would have to be in "good standing" in the methadone maintenance program in order to participate; i.e., compliance with scheduled medication and group therapy session hours. This would be defined as < 3 missed methadone medications and missed < 3 group and <3 individual therapy sessions in the two months prior to study participation
- Subjects must submit a urine sample negative for illicit drugs prior to study entry.
- Subjects must be able to read and understand English.
Exclusion Criteria:
- Unstable medical condition (e.g., major, unstable cardiovascular, renal, endocrine or hepatic disease) or stable medical condition requiring treatment that would interact with study medications (e.g., controlled hypertension on an antihypertensive) or ability to participate in study sessions, (e.g.,chronic back pain that would preclude being able to sit for long periods, etc), to be determined by history provided by the prospective subject or laboratory evaluation and physical examination as outlined below. These would be determined by the study physician alone or in consultation with the PI.
- Current diagnosis of other drug or alcohol physical dependence (other than tobacco).
- History of major psychiatric disorder (psychosis, schizophrenia, bipolar) or current psychiatric disorder that requires medication (e.g., current major depression).
- Pregnancy, plans to become pregnant or inadequate birth control (adequate birth control includes an IUD, condoms, birth control pills, etc). Male participants are encouraged to use condoms because little has been studied on the effects of these drugs on the male reproductive system.
- Present or recent use of over-the-counter psychoactive drug, prescription psychoactive drug (antidepressants, anxiolytics, antipsychotics and anticonvulsants that may also be used for mood stabilization or sleep disruption) or drug (e.g., ciprofloxacin, fluvoxamine) that would have major interaction with drugs to be tested.
- Liver function tests greater than 3 times normal, BUN and Creatinine outside normal range, or thyroid function tests outside normal range.
- A supine or semi-recumbent blood pressure of 100/65mmHg, a seated blood pressure of 90/60mmHg, or orthostatic change of >20mmHg systolic or >10mmHg diastolic on standing or heart rate less than 60 beats/min.
- EKG abnormalities including but not limited to: bradycardia (<60 bpm); prolonged QTc interval (>450 msec); Wolff-Parkinson White syndrome; wide complex tachycardia; 2nd degree, Mobitz type II heart block; 3rd degree heart block; left or right bundle branch block.
- Participants who become arrested and/or incarcerated will not be allowed to continue to participate.
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Grundvidenskab
- Tildeling: N/A
- Interventionel model: Enkelt gruppeopgave
- Maskning: Dobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
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Eksperimentel: 1
Receives 2-4 of the drugs listed under Intervention
|
Cycloserine: 500, 675, 750 mg oral capsules may possibly given.
Naloxone: 0.15mg/70Kg or 0.2mg/70kg I.M. injection may possibly be given.
Nifedipine: 10, 20 mg oral capsules may possibly be given.
Placebo (sugar pill or microcrystalline cellulose): oral capsules may be given.
Saline: I.M. injection may possibly be given.
Tizanidine: 4, 8, 12 mg oral capsules may possibly be given.
Verapamil: 30, 60, 120 mg oral capsules may possibly be given.
Andre navne:
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
---|---|
Drug Discrimination Performance
Tidsramme: Every Session
|
Every Session
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Sekundære resultatmål
Resultatmål |
Tidsramme |
---|---|
ECG
Tidsramme: Test Sessions
|
Test Sessions
|
Vitale tegn
Tidsramme: Hver session
|
Hver session
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Self-Report Ratings
Tidsramme: Every Session
|
Every Session
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Alison Oliveto, Ph.D., University of Arkansas
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. februar 2010
Primær færdiggørelse (Faktiske)
1. oktober 2012
Studieafslutning (Faktiske)
1. november 2012
Datoer for studieregistrering
Først indsendt
12. februar 2010
Først indsendt, der opfyldte QC-kriterier
12. februar 2010
Først opslået (Skøn)
15. februar 2010
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
7. marts 2013
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
6. marts 2013
Sidst verificeret
1. marts 2013
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
- Psykiske lidelser
- Kemisk inducerede lidelser
- Stof-relaterede lidelser
- Lægemidlers fysiologiske virkninger
- Adrenerge midler
- Neurotransmittermidler
- Molekylære mekanismer for farmakologisk virkning
- Anti-arytmimidler
- Vasodilatorer
- Anti-infektionsmidler
- Parasympatholytika
- Autonome agenter
- Agenter fra det perifere nervesystem
- Analgetika
- Sensoriske systemagenter
- Antimetabolitter
- Adrenerge alfa-2-receptoragonister
- Adrenerge alfa-agonister
- Adrenerge agonister
- Antibakterielle midler
- Membrantransportmodulatorer
- Narkotiske antagonister
- Antikonvulsiva
- Calciumregulerende hormoner og midler
- Reproduktive kontrolmidler
- Calciumkanalblokkere
- Neuromuskulære midler
- Antituberkulære midler
- Tokolytiske midler
- Antibiotika, Antituberkulær
- Muskelafslappende midler, Central
- Anti-infektionsmidler, urinveje
- Nyremidler
- Naloxon
- Nifedipin
- Cycloserin
- Verapamil
- Tizanidin
Andre undersøgelses-id-numre
- R01DA010017-03 (U.S. NIH-bevilling/kontrakt)
- DPMC (Anden identifikator: NIDA)
- R01DA010017 (U.S. NIH-bevilling/kontrakt)
- 110528
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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