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Effects of Magnesium and Spinning Training on Echocardiographic, Inflammatory, and Aerobic Outcomes

17. juni 2026 opdateret af: Hikmet Kocaman, Karamanoğlu Mehmetbey University

Effects of Magnesium Supplementation and Spinning Training on Cardiac Function, Oxidative Stress, Inflammation, and Aerobic Capacity

Regular aerobic exercise may improve cardiorespiratory fitness while modulating systemic inflammation and oxidative stress. Spinning, as a structured indoor cycling modality, provides a practical aerobic exercise model with adjustable intensity and duration, but its effects on redox balance, inflammatory status, aerobic capacity, and cardiac functional parameters may vary according to individual recovery and nutritional status. Magnesium is an essential micronutrient involved in energy metabolism, muscle contraction-relaxation, ion regulation, and inflammatory and oxidative pathways; therefore, magnesium use may be relevant to exercise adaptation and recovery.

This study aims to evaluate the associations of magnesium use and spinning training with oxidative stress, inflammation, aerobic capacity, and cardiac parameters. In this context, biochemical markers related to oxidative/antioxidant status and inflammation, aerobic performance indicators, and echocardiographic cardiac function parameters will be assessed together. The study is expected to provide real-world evidence on whether magnesium use in individuals participating in spinning training is associated with more favorable redox, inflammatory, aerobic, and cardiac profiles.

Studieoversigt

Status

Tilmelding efter invitation

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

48

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Tyrkiet (Türkiye)
      • Karaman, Tyrkiet (Türkiye), 70100
        • Karamanoğlu Mehmetbey University, Faculty of Sport Sciences

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen

Tager imod sunde frivillige

Ja

Beskrivelse

Inclusion Criteria:

  • Self-identified male participants
  • Aged 18 to 30 years
  • Physically active individuals
  • Participants who are eligible to participate in a structured spinning training program
  • Participants with available baseline and follow-up assessments for biochemical, aerobic capacity, and cardiac function parameters

Exclusion Criteria:

  • Presence of any chronic systemic disease
  • Acute infection during the study period
  • Regular use of anti-inflammatory or antioxidant medications
  • Use of antioxidant or ergogenic supplements other than magnesium
  • Any cardiovascular, musculoskeletal, or neurological condition that may limit participation in spinning training
  • Missing baseline or follow-up outcome data

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Grundvidenskab
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Enkelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Ingen indgriben: Control group
Participants in this arm will not receive any exercise training, magnesium supplementation, or placebo intervention during the study period. They will continue their usual daily routines and will undergo the same baseline and follow-up assessments as the intervention groups.
Aktiv komparator: Spinning Training Group
Participants in this arm will participate in a structured spinning training program during the study period. No magnesium supplementation or placebo will be administered. Baseline and follow-up assessments will include oxidative stress, inflammatory, aerobic capacity, and cardiac function parameters.
Adfærdsmæssigt: Spinning Training
Participants will participate in a structured spinning training program during the study period. The program will consist of supervised indoor cycling sessions performed at a planned frequency, duration, and intensity.
Eksperimentel: Spinning + Magnesium Group
Participants in this arm will participate in a structured spinning training program and receive magnesium supplementation during the study period. Baseline and follow-up assessments will include oxidative stress, inflammatory, aerobic capacity, and cardiac function parameters.
Adfærdsmæssigt: Spinning Training
Participants will participate in a structured spinning training program during the study period. The program will consist of supervised indoor cycling sessions performed at a planned frequency, duration, and intensity.
Kosttilskud: Magnesium Supplementation
Participants will receive oral magnesium supplementation during the study period in addition to the structured spinning training program.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Change in Maximal Oxygen Uptake (VO₂max)
Tidsramme: Baseline and 6 weeks
Maximal oxygen uptake (VO₂max, mL/kg/min) will be assessed using a graded exercise test. The change in VO₂max from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in Serum Magnesium Concentration
Tidsramme: Baseline and 6 weeks
Serum magnesium concentration (mg/dL) will be measured using standard laboratory methods. The change in serum magnesium levels from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Change in Total Antioxidant Status (TAS)
Tidsramme: Baseline and 6 weeks
Serum total antioxidant status (TAS, mmol Trolox equivalent/L) will be measured using commercially available assay kits. The change in TAS from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in Total Oxidant Status (TOS)
Tidsramme: Baseline and 6 weeks
Serum total oxidant status (TOS, μmol H₂O₂ equivalent/L) will be measured using commercially available assay kits. The change in TOS from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in Paraoxonase-1 Activity (PON1)
Tidsramme: Baseline and 6 weeks
Serum paraoxonase-1 (PON1, U/L) activity will be determined using spectrophotometric methods. The change in PON1 activity from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in Arylesterase Activity (ARE)
Tidsramme: Baseline and 6 weeks
Serum arylesterase (ARE, kU/L) activity will be determined using spectrophotometric methods. The change in ARE activity from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in High-Sensitivity C-Reactive Protein (hs-CRP)
Tidsramme: Baseline and 6 weeks
Serum high-sensitivity C-reactive protein (hs-CRP, mg/L) concentration will be measured using standard laboratory methods. The change in hs-CRP levels from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in Interleukin-6 (IL-6)
Tidsramme: Baseline and 6 weeks
Serum interleukin-6 (IL-6, pg/mL) concentration will be measured using enzyme-linked immunosorbent assay methods. The change in IL-6 levels from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in Tumor Necrosis Factor-Alpha (TNF-α)
Tidsramme: Baseline and 6 weeks
Serum tumor necrosis factor-alpha (TNF-α, pg/mL) concentration will be measured using enzyme-linked immunosorbent assay methods. The change in TNF-α levels from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in Serum Potassium Concentration
Tidsramme: Baseline and 6 weeks
Serum potassium concentration (mmol/L) will be measured using standard biochemical methods. The change in serum potassium levels from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in Serum Calcium Concentration
Tidsramme: Baseline and 6 weeks
Serum calcium concentration (mg/dL) will be measured using standard biochemical methods. The change in serum calcium levels from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in N-Terminal Pro-B-Type Natriuretic Peptide (NT-proBNP)
Tidsramme: Baseline and 6 weeks
Serum N-terminal pro-B-type natriuretic peptide (NT-proBNP, pg/mL) concentration will be measured using immunoassay methods. The change in NT-proBNP levels from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks
Change in Left Ventricular Ejection Fraction (LVEF)
Tidsramme: Baseline and 6 weeks
Left ventricular ejection fraction (LVEF, %) will be assessed by transthoracic echocardiography. The change in LVEF from baseline to 6 weeks will be evaluated.
Baseline and 6 weeks

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Karamanoğlu Mehmetbey University

Efterforskere

  • Ledende efterforsker: Şemsi Gül Yılmaz Kocaman, PhD, Karamanoglu Mehmetbey University

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. juni 2026

Primær færdiggørelse (Anslået)

15. august 2026

Studieafslutning (Anslået)

20. august 2026

Datoer for studieregistrering

Først indsendt

5. juni 2026

Først indsendt, der opfyldte QC-kriterier

17. juni 2026

Først opslået (Faktiske)

23. juni 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

23. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

17. juni 2026

Sidst verificeret

1. juni 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 02-2026/29

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

IPD-planbeskrivelse

Individual participant data will not be shared because the dataset contains participant-level health and performance records. All results will be reported in aggregate form, and confidentiality will be maintained in accordance with applicable data protection regulations.

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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