- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT00030563
Surgery With or Without Radiofrequency Ablation Followed by Irinotecan in Treating Patients With Colorectal Cancer That is Metastatic to the Liver
A Phase II Study Of Adjuvant Intravenous Irinotecan Following Resection With Or Without Radiofrequency Ablation (RFA), Of Hepatic Metastases From Colorectal Carcinoma
RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. Combining radiofrequency ablation with surgery may kill more tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving a chemotherapy drug after surgery and radiofrequency ablation may kill any remaining tumor cells.
PURPOSE: Phase II trial to determine the effectiveness of surgery with or without radiofrequency ablation followed by irinotecan in treating patients who have colorectal cancer that is metastatic to the liver.
연구 개요
상세 설명
OBJECTIVES:
- Determine the disease-free survival in patients with hepatic metastases from primary colorectal carcinoma treated with surgical resection with or without radiofrequency ablation followed by irinotecan.
- Determine the overall survival in patients treated with this regimen.
- Determine the treatment-related toxicity of this regimen in these patients.
- Correlate the measurement of molecular markers with clinical outcome in patients treated with this regimen.
OUTLINE: This is a multicenter study. Patients are stratified according to treatment with radiofrequency ablation in addition to resection (yes vs no).
Patients undergo surgical resection with or without radiofrequency ablation. Beginning 4-8 weeks after surgery, patients receive irinotecan IV over 90 minutes on day 1. Chemotherapy repeats every 3 weeks for a total of 6 courses in the absence of disease progression or unacceptable toxicity.
Patients are followed at 4 weeks, every 3 months for 2 years, every 6 months for 3 years, and then annually thereafter.
PROJECTED ACCRUAL: A total of 70 patients will be accrued for this study.
연구 유형
단계
- 2 단계
연락처 및 위치
참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
DISEASE CHARACTERISTICS:
- Histologically confirmed primary colorectal adenocarcinoma
Hepatic metastases that are considered completely resectable
- No more than 4 metastases by dual phase CT scan OR
Hepatic metastases that are not completely resectable but are amenable to complete destruction with resection and radiofrequency ablation
- More than 4 metastases allowed if all disease can be resected or destroyed in situ with radiofrequency ablation
- No extrahepatic disease in any location
- No recurrent or second primary colorectal cancer by colonoscopy within the past year
- Received prior adjuvant chemotherapy with a fluorouracil-based regimen with the last dose at least 1 month prior to surgery
- No prior radiofrequency ablation with residual viable intrahepatic disease by CT scan
- No plans to be treated with radiofrequency ablation alone without surgical resection
PATIENT CHARACTERISTICS:
Age:
- 18 and over
Performance status:
- ECOG 0-1
Life expectancy:
- Not specified
Hematopoietic:
- Absolute neutrophil count at least 1,500/mm^3
- Platelet count at least 100,000/mm^3
Hepatic:
- Bilirubin no greater than 1.5 times upper limit of normal (ULN)
- AST and ALT no greater than 5 times ULN
- No Gilbert's disease or other known defect in hepatic conjugation or glucuronidation
Renal:
- Creatinine no greater than 1.5 times ULN
Cardiovascular:
- No myocardial infarction within the past 6 months
- No congestive heart failure requiring therapy
Other:
- Not pregnant or nursing
- Fertile patients must use effective contraception during and for 30 days after study
- No other malignancy within the past 5 years except inactive non-melanoma skin cancer or carcinoma in situ of the cervix
- No active serious infection
- No other serious underlying medical condition or severe concurrent disease that would preclude study participation
- No dementia, significantly altered mental status, or psychiatric illness that would preclude study participation
- No known hypersensitivity to irinotecan
- No known infection with HIV or AIDS
- No uncontrolled diabetes mellitus
- No history of seizures
- No drug or alcohol abuse within the past year
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- See Disease Characteristics
- No prior irinotecan
Endocrine therapy:
- Not specified
Radiotherapy:
- No prior radiotherapy to more than 30% of bone marrow
- No prior radiotherapy to the liver
- At least 3 months since prior radiotherapy to the pelvis or other areas
Surgery:
- See Disease Characteristics
- No prior resection of hepatic metastases (wedge biopsy allowed)
Other:
- No concurrent phenytoin, phenobarbital, or other antiepileptic medication
- No concurrent enrollment in other investigational drug trials
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
공동 작업자 및 조사자
수사관
- 연구 의자: Kevin G. Billingsley, MD, University of Washington
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
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