A Study to Assess the Safety, Tolerability, Pharmacokinetics, Food Effect, and Drug-Drug Interaction Potential of ACHN-383 and ACHN-789

Key Inclusion Criteria:

• Females of child-bearing potential must not be breast feeding, must have a negative serum pregnancy test, and must use a highly effective method of contraception or be abstinent from sexual activity prior to the first dose of study, during the study and for a specified period following the last dose of study drug
• Males must be willing to use a condom for the duration of the study and for a specified period following the study, unless surgically sterile. In addition, their female partner must use a highly effective method of contraception, for the same period of time, unless surgically sterile
• Body mass index (BMI) of ≥19 kg/m^2 to ≤32 kg/m^2 and weight ≥50 kg to ≤125 kg
• Normal renal function as determined by creatinine clearance (CLcr) rate

Key Exclusion Criteria:

• Pregnant women
• History of any hepatic or biliary disorder or disease
• Any condition that could possibly affect oral drug absorption
• Unstable cardiovascular disease
• Uncontrolled hypertension, asthma, diabetes, thyroid disease, or seizure disorder
• HIV positive
• Active malignancy