Assessment of Thrombotic Status in Patients at Risk of Cardiovascular Thrombosis

Inclusion Criteria:

1. Male and female participants aged 18 years or over.
2. Patients diagnosed with CAD or AF and free of exclusion criteria below.
3. Not actively using tobacco products (due to vasoactive and pro-aggregatory effects of nicotine).
4. The participant is willing and able to understand the Subject Information Sheet and provide informed consent.
5. The participant must agree to comply with the drawing of blood samples for the assessments.

Exclusion Criteria:

1. Male and female participants aged < 18 years of age.
2. Patients with impaired renal function eGFR <30 ml/min (since renal failure is associated with platelet function defect that may confound results).
3. The participant has, in the opinion of the investigator, significant neurological, hepatic, renal, endocrine, cardiovascular, gastrointestinal, pulmonary, haemorrhagic metabolic or other disease likely to confound the study requirements or analyses.
4. The participant has a gives a history of substance abuse or demonstrates signs or clinical features of active substance abuse or psychiatric disease.
5. Alcohol consumption above recommended safe levels (i.e. more than 21 units per week for males, or more than 14 units per week for females) due to the potential effects of high alcohol levels on platelet reactivity.
6. Any illness deemed significant by the investigator during the four (4) weeks preceding the screening period of the study.
7. Any major bleeding diathesis or blood dyscrasia (platelets < 70 x 109/l, Hb <8 g/dl, INR>1.4, APTT> x 2UNL, leucocyte count< 3.5x 109/l, neutrophil count < 1x 109/l)
8. Currently enrolled in an investigational device or drug trial.