HSV Oral Reactivation in Children

Inclusion Criteria:

• age > 3 and ≤12 years old
• parental/guardian consent and children's assent must be obtained and participants and parent/guardian must be able to comply with study procedures
• For HIV-infected group: Positive HIV serology by either ELISA x 2, ELISA + WB or PCR testing

Exclusion Criteria:

• age <3 and > 12 years old
• Acute illness which by opinion of the investigator makes enrollment in the trial unfeasible (including active tuberculosis, malaria or other opportunistic infection requiring treatment)
• co-enrollment in other therapeutic/intervention trials (observational trial enrollment is permitted).
• Stable co-administration of other medications is permitted (e.g. bactrim)
• For HIV-infected children; receiving or eligible for antiretroviral (ART) therapy by local standards