- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT00729352
Lung Mucus Hypersecretion and NQO1
Dependency of O3-Induced Lung Mucus Hypersecretion on NQO1
Study Overview
Status
Detailed Description
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
North Carolina
-
Durham, North Carolina, United States, 27710
- Duke University Medical Center
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
-
Exclusion Criteria:subjects with current or past smoking history, acute respiratory illness within six weeks of the study, and significant non-pulmonary disease as determined by the investigator, pregnancy, age <18 or >35 yr, or inability to understand the protocol. Subjects will be requested to refrain from anti-histamines, nonsteroidal anti-inflammatory agents, and supplemental vitamins, e.g. C and E, for 1 week prior to, and during lab visits for exposures and follow-up measures.
-
Study Plan
How is the study designed?
Design Details
- Observational Models: Case-Crossover
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
---|
Control group
18-35 yr old healthy subjects with wild type genotype for NQO1.
|
Case group
18-35 yr old healthy subjects who are homozygotic for minor allele of NQO1 Pro187Ser polymorphism
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Airway Mucociliary Clearance
Time Frame: 6-24 h post-exposure to filatered air or ozone.
|
6-24 h post-exposure to filatered air or ozone.
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Bronchial Epithelial Cells obtained by bronchoalveolar lavage.
Time Frame: 6-24 h post-exposure to filtered air or ozone.
|
6-24 h post-exposure to filtered air or ozone.
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 16347-CP-001
- 00008404
- R01ES016347 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Air Pollution
-
U.S. EPA Human Studies FacilityRecruitingAir PollutionUnited States
-
UConn HealthNational Institute of Environmental Health Sciences (NIEHS)Completed
-
University Hospitals Cleveland Medical CenterPeking University; University of MichiganCompletedAir PollutionUnited States, China
-
Stanford UniversityDuke University; National Institute of Environmental Health Sciences (NIEHS)CompletedPregnancy | Air PollutionUnited States
-
Environmental Protection Agency (EPA)Enrolling by invitationAir Pollution | Pollution; Exposure | Nutrition, HealthyUnited States
-
University of LouisvilleNational Institute of Environmental Health Sciences (NIEHS)Completed
-
Rutgers, The State University of New JerseyNational Institute of Environmental Health Sciences (NIEHS)Completed
-
University of MichiganCompletedAir PollutionUnited States
-
Rutgers, The State University of New JerseyCompleted
-
University of Southern CaliforniaDuke UniversityRecruiting