- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01413555
Multicenter Blood Culture Quality Improvement
Multicenter Implementation of a Quality Improvement Program to Reduce Blood Culture Contamination in the Emergency Department
Study Overview
Detailed Description
The Blood Culture QI Program has four components: (1) education: content knowledge and standardized experiential training on sterile technique designed for ED nurses; (2) process redesign: change in patient safety attitude and conversion of blood culture collection from a clean to a sterile technique; (3) checklist use: reinforcement of optimal blood culture collection technique at the point of care; (4) feedback: systematic charting and reporting of contamination rates to the ED nurses who collect cultures. In order to convert blood culture collection into a fully sterile procedure, the investigators developed the Sterile Blood Culture Collection Kit, a novel materials kit that contains the equipment needed to collect a culture using sterile technique, including: (1) a 3ml solution of 2% chlorhexidine gluconate - 70% isopropyl alcohol (Chloraprep, CareFusion) skin prep device; (2) a sterile drape; (3) a sterile needle; and (4) gauze.
The investigators will evaluate the effectiveness of the Blood Culture QI Program after implementing it in six community hospital EDs. Our study will compromise six replications of an interrupted time series study wherein each replication will be powered for internal validity to test the hypothesis of decreasing the contamination rate by 50% at each site. A stepped wedge (also called multiple baseline) design will be used to implement the program across hospitals to evaluate the generalizability (external validity) of program effectiveness. The primary analysis will be an interrupted time series analysis at each site comparing the proportion of ED blood cultures contaminated during a post-implementation intervention period with a pre-intervention baseline period.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
Tennessee
-
Nashville, Tennessee, United States, 37232-4700
- Vanderbilt Emergency Medicine
-
Nashville, Tennessee, United States, 37232-4700
- Vanderbilt University Medical Center Emergency Medicine
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Patients who have a blood culture ordered for clinical purposes in one of the participating centers during the study period.
Exclusion Criteria:
- Age < 18 years old
Study Plan
How is the study designed?
Design Details
- Primary Purpose: PREVENTION
- Allocation: NA
- Interventional Model: SINGLE_GROUP
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Blood Culture QI Program
|
The Blood Culture QI Program contains four components:(1) education: content knowledge and standardized experiential training on sterile technique designed for ED nurses; (2) process redesign: conversion of blood culture collection from a clean to a sterile technique using the Blood Culture Sterile Kit; (3) a checklist outlining optimal use of the Kit; (4) feedback of blood culture contamination rates to ED nurses who collect them.
Other Names:
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Biweekly proportion of ED blood cultures contaminated
Time Frame: 1 year
|
In an interrupted time series design, we will compare the proportion of blood cultures contaminated during an intervention period after the implementation of the Blood Culture QI Program to a baseline period before implementation.
We will complete six separate interrupted time series analyses with one at each of six hospitals.
The intervention and baseline period duration will be approximately one year at each hospital.
|
1 year
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Wesley H. Self, MD, MPH, Vanderbilt University Medical Center
Publications and helpful links
General Publications
- Archibald LK, Pallangyo K, Kazembe P, Reller LB. Blood culture contamination in Tanzania, Malawi, and the United States: a microbiological tale of three cities. J Clin Microbiol. 2006 Dec;44(12):4425-9. doi: 10.1128/JCM.01215-06. Epub 2006 Oct 4.
- Norberg A, Christopher NC, Ramundo ML, Bower JR, Berman SA. Contamination rates of blood cultures obtained by dedicated phlebotomy vs intravenous catheter. JAMA. 2003 Feb 12;289(6):726-9. doi: 10.1001/jama.289.6.726.
- Qamruddin A, Khanna N, Orr D. Peripheral blood culture contamination in adults and venepuncture technique: prospective cohort study. J Clin Pathol. 2008 Apr;61(4):509-13. doi: 10.1136/jcp.2007.047647. Epub 2007 Aug 30.
- Bates DW, Goldman L, Lee TH. Contaminant blood cultures and resource utilization. The true consequences of false-positive results. JAMA. 1991 Jan 16;265(3):365-9.
- Little JR, Murray PR, Traynor PS, Spitznagel E. A randomized trial of povidone-iodine compared with iodine tincture for venipuncture site disinfection: effects on rates of blood culture contamination. Am J Med. 1999 Aug;107(2):119-25. doi: 10.1016/s0002-9343(99)00197-7.
- Gander RM, Byrd L, DeCrescenzo M, Hirany S, Bowen M, Baughman J. Impact of blood cultures drawn by phlebotomy on contamination rates and health care costs in a hospital emergency department. J Clin Microbiol. 2009 Apr;47(4):1021-4. doi: 10.1128/JCM.02162-08. Epub 2009 Jan 26.
- Souvenir D, Anderson DE Jr, Palpant S, Mroch H, Askin S, Anderson J, Claridge J, Eiland J, Malone C, Garrison MW, Watson P, Campbell DM. Blood cultures positive for coagulase-negative staphylococci: antisepsis, pseudobacteremia, and therapy of patients. J Clin Microbiol. 1998 Jul;36(7):1923-6. doi: 10.1128/JCM.36.7.1923-1926.1998.
- Zwang O, Albert RK. Analysis of strategies to improve cost effectiveness of blood cultures. J Hosp Med. 2006 Sep;1(5):272-6. doi: 10.1002/jhm.115.
Study record dates
Study Major Dates
Study Start
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ESTIMATE)
Study Record Updates
Last Update Posted (ESTIMATE)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- VHRPP - 101722
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Bacteremia
-
Armata Pharmaceuticals, Inc.United States Department of DefenseRecruitingBacteremia | Staphylococcus Aureus | Staphylococcus Aureus Bacteremia | Bacteremia Due to Staphylococcus Aureus | Bacteremia StaphUnited States, Australia
-
Osijek University HospitalCompletedSepsis | Gram-negative Bacteremia | Gram-Positive BacteremiaCroatia
-
Rabin Medical CenterCompletedGram Negative BacteremiaIsrael, Italy
-
Duke UniversityMerck Sharp & Dohme LLCCompletedBacteremia | Gram-negative BacteremiaUnited States
-
The First Affiliated Hospital of Xinxiang Medical...RecruitingSalmonella BacteremiaChina
-
Fundación Pública Andaluza para la gestión de la...Spanish Clinical Research Network - SCReN; Spanish Network for Research in...RecruitingEnterococcal BacteremiaSpain
-
LegoChem Biosciences, IncRecruitingMRSA BacteremiaKorea, Republic of
-
The University of Texas Health Science Center,...RecruitingEnterococcal BacteremiaUnited States, Germany, Spain, Argentina, Chile
-
Aimee LiCompleted
-
Singapore General HospitalSingapore Clinical Research InstituteTerminatedBacteremia Due to Staphylococcus AureusSingapore
Clinical Trials on Blood Culture QI Program
-
VA Office of Research and DevelopmentCompletedStroke | Transient Ischemic AttackUnited States
-
University of MinnesotaCompletedChronic Kidney DiseaseUnited States
-
Central Hospital, Nancy, FranceCompletedBacteremia | Infective EndocarditisFrance
-
Dongfang Hospital Beijing University of Chinese...Xingtai People's HospitalUnknownCerebral InfarctionChina
-
Assiut UniversityUnknownBlood Stream InfectionEgypt
-
Assiut UniversityUnknownNeonatal SepsisEgypt
-
Centre Hospitalier Universitaire de NiceCompletedBacteremia | Catheter-Related InfectionsFrance
-
Southeast University, ChinaThe First Affiliated Hospital with Nanjing Medical University; Northern Jiangsu...Recruiting
-
Assiut UniversityNot yet recruitingVAP - Ventilator Associated Pneumonia
-
Stanford UniversityBoston Scientific CorporationUnknownCholedocholithiasis | Bile Duct StrictureUnited States