- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01800786
Memory Consolidation in Obstructive Sleep Apnea
The overarching goal of the research proposed here is to test the hypothesis (i) that the pathophysiological mechanisms of OSA lead to deterioration in sleep-dependent memory consolidation across memory systems, with the genetic marker APOε4 as a modulator, and (ii) that CPAP can reverse some or all of these measured memory deficits.
In addition, we are exploring which aspects of OSA (e.g., changes in sleep architecture, measures of hypoxemia, or the EEG power spectrum) most likely impact sleep-dependent memory processing.To this end, we are using specific cognitive tasks for which sleep-dependent memory consolidation processes have previously been demonstrated by our group and others. In addition, we are carrying out quantitative EEG power spectral analyses, to delineate abnormal functioning of brain regions with more precision.
Study Overview
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Massachusetts
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Boston, Massachusetts, United States, 02115
- Brigham and Women's Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Subject selection
General inclusion criteria:
- Men and women ages 18 to 80 years old
- Good health as determined by a medical and psychiatric history and physical examination
- An absence of any medical or psychiatric disorders (other than OSA and treated hypertension) that could influence excessive daytime sleepiness
- The ability to complete self-rating scales and computer-based testing
- Beck Depression Inventory score ≤16
- Healthy controls will be excluded with and Epworth Sleepiness Scale (ESS) score > 10/24, OSA patients will be excluded from randomization with an ESS score >18/24.
- Subjects must agree to abstain from alcohol consumption from the day before and throughout Session 1 and Session 2.
Criteria for OSA patients:
- Newly diagnosed with OSA and with no prior exposure to CPAP
- Quantified apnea-hypopnea index greater than 5/hr (AHI, defined as the number of apneas and/or hypopneas per hour of sleep)
- Subjects must agree to limit alcohol use between Session 1 and Session 2 to one or fewer alcoholic drinks daily or up to 4 drinks weekly
Criteria for Healthy control group:
• Subjects will be matched to the obstructive sleep apnea patient group for age, race, body mass index, education and intelligence (WAIS - full scale)
Subgroup selection:
An additional subgroup of OSA patients and controls, who are taking antidepressants, will be recruited. Except for the current treatment with antidepressants all other exclusion and exclusion criteria will be applied.
The following classes of antidepressants will be eligible:
- Selective serotonin reuptake inhibitors
- Serotonin-norepinephrine reuptake inhibitors
- Noradrenergic and specific serotonergic antidepressants
- Norepinephrine-dopamine reuptake inhibitors
Exclusion criteria
ALL PARTICIPANTS:
Potential participants (OSA patients and controls) are excluded if one or more of the following conditions are found:
- Any history of clinically significant, uncontrolled medical or psychiatric condition (treated or untreated), other than OSA and hypertension (self-report)
- History of serious heart disease or renal failure (self-report)
- History of head injury (self-report)
- Inability to type (e.g., physical disability, arthritis) or to exercise
- A lifetime history of alcohol, narcotic or any other drug abuse (self-report)
- Use of medications, over-the counter drugs or nutritional supplements known to have an effect on sleep, cognition and/or daytime vigilance (self-report)
- Female subjects who are pregnant cannot take part in the study. If a female subject becomes pregnant during the study, she will have to stop participation
Presence of any of the following sleep disorders:
- Cheyne-Stokes breathing or central sleep apnea (> 10% of events central) (screening sleep study)
- Circadian rhythm disorder (structured interview)
- REM sleep without atonia or REM behavior disorder (structured interview and screening sleep study )
- Parasomnias (structured interview)
- PLMS index of >15/h (screening sleep study)
- Insomnia (structured interview and 2 weeks sleep diaries)
- Narcolepsy (structured interview)
- Left-handedness (only MSLT participants)- (self-report)
- uncorrected vision impairment and/or visual field defect (self report, screening examination)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Active Comparator: OSA-CPAP group
OSA patient will use CPAP for 3 months
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No Intervention: OSA -no CPAP
newly diagnosed OSA patient will not wear CPAP for 3 months
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Overnight Change in Declarative Memory Performance
Time Frame: 3 months
|
At 3 months, we compared average overnight changes between evening and morning performance on a declarative memory test between untreated OSA subjects and those who received CPAP therapy for 3 months. Positive numbers represent an increase in performance. |
3 months
|
Collaborators and Investigators
Sponsor
Collaborators
Investigators
- Principal Investigator: Ina Djonlagic, MD, Brigham and Women's Hospital
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- OSAM
- K23HL103850-01 (U.S. NIH Grant/Contract)
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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