- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03171402
Astringency and Bitterness Perception
Astringency and Bitterness Perception Among High and Low Fruit and Vegetable Consumers
The investigators are conducting a study to better understand how the average consumer differentiates between bitter and astringent sensations, both of which are typically unpleasant sensations characteristic of some healthy foods. Astringency is the dry/rough sensation elicited by foods such as green bananas and some wines. Although trained scientists can differentiate between these stimuli, untrained participants rate them similarly, despite their differences. This confusion has created additional barriers in understanding the mechanism of astringent perception, which is currently debated. Understanding how to design experiments where untrained participants can clearly evaluate both sensations will lay the foundation to better understand astringency.
One mechanism that is believed to contribute to astringency is the interaction of astringent stimuli with salivary proteins. Interestingly, the salivary protein profile may be influenced by consumption of fruits and vegetables. Therefore, the investigators will evaluate how bitter and astringent perceptions differ among high and low consumers of fruits and vegetables by collecting saliva following exposure to the stimuli. This knowledge will inform approaches to increase the appeal of healthy food.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Contacts and Locations
Study Locations
-
-
Indiana
-
West Lafayette, Indiana, United States, 47907
- Purdue University
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
- Not underweight (BMI > 18 kg/m^2)
- Not be trying to gain or lose weight
- Males and females 18-45
- No known issues with taste, smell, swallowing, choking, or salivation
Description
Inclusion Criteria:
- BMI > 18
Exclusion Criteria:
- issues with taste, smell, swallowing, choking, or salivation
- trying to gain or lose weight
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Low fruit and vegetable consumers
Participants with low F&V consumption, as defined by 24-hr dietary recall
|
Participants will be involved in 1-4 experiments that test how they rate and differentiate between bitter and astringent flavored beverage samples
|
High fruit and vegetable consumers
Participants with high F&V consumption, as defined by 24-hr dietary recall
|
Participants will be involved in 1-4 experiments that test how they rate and differentiate between bitter and astringent flavored beverage samples
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Participant-generated sensory ratings of consumed samples
Time Frame: Through study completion, an average of three 30-minute visits
|
Liking and flavor intensity ratings on the general labeled magnitude scale
|
Through study completion, an average of three 30-minute visits
|
Participant-generated groupings of consumed samples
Time Frame: Through study completion, an average of three 60-minute visits
|
Hierarchical clustering of sample similarity
|
Through study completion, an average of three 60-minute visits
|
Participant-generated ratings of consumed samples relative to reference samples
Time Frame: Through study completion, an average of three 60-minute visits
|
Similarity ratings of samples compared to three reference samples on a visual analog scale
|
Through study completion, an average of three 60-minute visits
|
Participant-generated "check-all-that-apply" ratings of consumed samples
Time Frame: Through study completion, an average of three 30-minute visits
|
10-20 descriptors that are checked or unchecked by each participant to describe each sample
|
Through study completion, an average of three 30-minute visits
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Other Study ID Numbers
- 082-007
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Taste Bitter-Salty
-
Johns Hopkins UniversityNational Institute on Drug Abuse (NIDA)CompletedFeeding Behavior | Taste Sweet | Taste SaltyUnited States
-
Ministry of Health, Saudi ArabiaNot yet recruitingTaste Disorders | Smell Disorder | Smell Dysfunction | Taste Disorder, Secondary, Sweet | Taste Disorder, Secondary, Bitter
-
Nutricia ResearchCompletedOncology | Taste, AlteredNetherlands
-
You First ServicesCompletedMedication Associated Metallic Taste , DysgeusiaUnited States
-
Dow University of Health SciencesCompleted
-
Monell Chemical Senses CenterPepsiCo Global R&DCompletedSweet Taste PerceptionUnited States
-
CerecinCompletedTaste Profile AssessmentsUnited States
-
Purdue UniversityCompleted
-
University of Colorado, DenverMcCormick Science InstituteCompleted
Clinical Trials on Astringency and bitterness perception
-
Egas Moniz - Cooperativa de Ensino Superior, CRLCompleted
-
Hospices Civils de LyonRecruiting
-
Hvidovre University HospitalUniversity of Southern DenmarkCompleted
-
Russell L. WoodsResearch to Prevent Blindness / Lions Club International FoundationNot yet recruitingCentral Visual Impairment
-
Ain Shams UniversityUnknownBreast Cancer | Clinical TrialsEgypt
-
Bnai Zion Medical CenterUnknown
-
University Hospital, CaenCompleted
-
Hasselt UniversityZiekenhuis Oost-LimburgRecruitingLow Back Pain | Pelvic Girdle PainBelgium
-
University Hospital, CaenUnknown