Evaluation of HEArt invoLvement in Patients With FABRY Disease
Prospective Monocentric Cohort Study to Evaluate Predictors for Heart Failure and Sudden Cardiac Death in Patients With Fabry Disease
Lead Sponsor: Wuerzburg University Hospital
|Source||Wuerzburg University Hospital|
This study evaluates predictors for the incidence of arrhythmias and sudden cardiac death as well as terminal heart failure in patients with Fabry disease.
Fabry disease is a rare disease and part of the group of lysosomal storage disorders. Natural history of Fabry disease has proven poor survival to ages >50 years outlining the importance to evaluate cardiac symptoms and outcomes of patients with Fabry disease.
This study is a prospective cohort study and observes patients since 2001. Through this long-term experience and the relative high number of patients this study is suggested to help estimating the risk of cardiac arrhythmias and sudden cardiac death (SCD) as well as death or heart transplantation due to terminal heart failure.
All patients in treatment in the Fabry Center Wuerzburg (FAZiT) are included in this study if informed consent is provided.
|Start Date||January 2001|
|Completion Date||March 2032|
|Primary Completion Date||March 2032|
Sampling Method: Non-Probability Sample
Inclusion Criteria: - Fabry disease (genetically confirmed) - Signed informed consent - 18 years and older Exclusion Criteria: - No informed consent - Withdrawal of informed consent
- Fabry disease (genetically confirmed)
- Signed informed consent
- 18 years and older
- No informed consent
- Withdrawal of informed consent
Minimum Age: 18 Years
Maximum Age: N/A
Last Name: Peter Nordbeck, MD, PhD
Email: [email protected]
Type: Principal Investigator
Investigator Affiliation: Wuerzburg University Hospital
Investigator Full Name: PD Dr. Peter Nordbeck
Investigator Title: Head Consultant Cardiology and Chief of Electrophysiology
|Has Expanded Access||No|
|Study Design Info||
Observational Model: Cohort
Time Perspective: Prospective