Restrictive Eating Disorders: From Childhood Orality Disorder to Adolescent Dysensoriality (ODYSSED)

Restrictive Eating Disorders: From Childhood Orality Disorder to Adolescent Dysensoriality (Orality Dysensoriality and Eating Disorder)

This study offers to determine whether adolescent patients with a restrictive eating disorder have variations in their sensoriality compared to a control group.

Study Overview

• Status: Completed
• Conditions: Avoidant Restrictive Food Intake Disorder; Eating Disorders in Adolescence
• Intervention / Treatment: Other: Sensory Processing Scale Inventory (SPSI); Other: Autism Spectrum Screening Quotient (ASSQ); Other: GAD 7; Other: Conners abridged; Other: EAT 26

Detailed Description

Eating disorders are a frequent reason for consultation in pediatrics at all ages.

When they are small, children may have an orality disorder. There are multiple potential causes for this disorder: psychogenic, oropraxic but also sensory. The treatment is then adapted to the patient, with, among other things, an orientation towards professionals trained in sensory disorders.

As they grow up, adolescents are particularly at risk of developing eating disorders, which are pathologies that correspond to a biopsychosocial model of understanding that includes psychogenetic, neuroendocrine and immune factors.

Despite major advances in the understanding of this disease, the sensory dimension for these patients is still little studied and is not taken into account in the treatment proposed to adolescents suffering from eating disorders.

• Study Type: Observational
• Enrollment (Actual): 29

Contacts and Locations

Study Locations

• France
  • IDF
    • Paris, IDF, France, 75014
      • Maison de Solenn Maison des Adolescents, Cochin Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 12 years to 18 years (ADULT, CHILD)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

The participants were all recruited at the Maison de Solenn, Cochin - Paris, a service specialized in the treatment of eating disorders for adolescents. The participants in the control group are patients followed in this center for another reason than an eating disorder. The participants were recruited in consultation, in day hospital or in complete hospitalization.

Description

Inclusion Criteria:

• Adolescent between 12 to 18 years old.
• Non-opposition of the adolescent and his or her legal guardians collected before the start of the study.
• Patient group: Diagnosis of restrictive eating disorders (Anorexia Nervosa typical or atypical, ARFID) meeting DSM-5 criteria.
• Control group: absence of eating disorders.

Exclusion Criteria:

• Eating disorders secondary to another psychiatric pathology.
• Precarious health status with somatic and/or psychiatric instability that does not allow to answer the questionnaire.
• Language barrier.
• Opposition of the adolescent and/or his/her legal representatives obtained before the start of the study
• Patient under " AME " (medical state help)

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Restrictive eating disorder group; Adolescents between 12 and 18 y.o. Restrictive eating disorders diagnosis (Anorexia Nervosa or ARFID) answering DSM-5 criteria	Other: Sensory Processing Scale Inventory (SPSI); The Sensory Processing Scale Inventory (SPSI) is the main questionnaire. It allows to define over and under sensitive profiles. It's a self-administrated questionnaire; Other: Autism Spectrum Screening Quotient (ASSQ); The ASSQ allows to detect autism spectrum disorders (ASD). This quotient is proposed to the group because the investigators know that ASD are often correlated with sensory integration disorders. It's answered by the participant's parents.; Other: GAD 7; The GAD7 questionnaire allows to detect anxiety disorder. This questionnaire is proposed to the group because the investigators know that anxiety disorders are often correlated with sensory integration disorders. It's a self-administrated questionnaire.; Other: Conners abridged; The Conners abridged questionnaire allows to detect attention-deficit hyperactivity disorder (ADHD). This questionnaire is proposed to the group because the investigators know that ADHD are often correlated with sensory integration disorders. The questionnaire is answered by the participant's parents.; Other: EAT 26; The EAT 26 questionnaire allows to detect anorexia nervosa. It is proposed to the patient with an eating disorder to establish the level of severity of their disease. It's a self-administrated questionnaire.
Control group; Adolescents between 12 and 18 y.o. No eating disorders	Other: Sensory Processing Scale Inventory (SPSI); The Sensory Processing Scale Inventory (SPSI) is the main questionnaire. It allows to define over and under sensitive profiles. It's a self-administrated questionnaire; Other: Autism Spectrum Screening Quotient (ASSQ); The ASSQ allows to detect autism spectrum disorders (ASD). This quotient is proposed to the group because the investigators know that ASD are often correlated with sensory integration disorders. It's answered by the participant's parents.; Other: GAD 7; The GAD7 questionnaire allows to detect anxiety disorder. This questionnaire is proposed to the group because the investigators know that anxiety disorders are often correlated with sensory integration disorders. It's a self-administrated questionnaire.; Other: Conners abridged; The Conners abridged questionnaire allows to detect attention-deficit hyperactivity disorder (ADHD). This questionnaire is proposed to the group because the investigators know that ADHD are often correlated with sensory integration disorders. The questionnaire is answered by the participant's parents.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Average Sensory Processing Scale Inventory (SPSI) scores between the two groups	Comparison of average Sensory Processing Scale Inventory (SPSI) scores between the two groups This questionnaire focuses on sensoriality. It allows the definition of over or under-reactive sensory profiles. It is made of two lists (list #1 : 73 items ; list #2 : 29 items). The SPSI questionnaire is in English. For this reason, a group of experts from La Maison de Solenn met to translate it into French being as faithful as possible to the original questionnaire. Each checklist has its own score, the result is the sum of the points obtained (one point for YES, zero points for NO) (6). Two groups will be formed: a group with eating disorders and a control group. The questionnaire will be answered only once and will be proposed to the participant at the end of a consultation at the Maison de Solenn for his usual follow-up or during a hospitalization (full time hospitalization or in day hospital).	Inclusion

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Screening for pathologies known to be associated with a sensory disorder	Screening questionnaires for Autism Spectrum Disorder (ASD) will be distributed in order to identify disorders associated with a particular sensory profile. This will allow statistical results to be refined by performing multivariate analyses.	Inclusion
Screening for pathologies known to be associated with a sensory disorder	Screening questionnaires for Attention Deficit Hyperactivity Disorder (ADHD) will be distributed in order to identify disorders associated with a particular sensory profile. This will allow statistical results to be refined by performing multivariate analyses.	Inclusion
Screening for pathologies known to be associated with a sensory disorder	Screening questionnaires for Generalized Anxiety Disorder (GAD) will be distributed in order to identify disorders associated with a particular sensory profile. This will allow statistical results to be refined by performing multivariate analyses.	Inclusion
Search for a link between the eating disorders severity and sensory disorders	The EAT 26 questionnaire is used to measure the severity of an eating disorder. It will be proposed only to the participants of the eating disorder group. This measure of severity will assess whether there is a relationship between the severity of the ED and the severity of the sensory disorders.	Inclusion

Collaborators and Investigators

• Sponsor: Assistance Publique - Hôpitaux de Paris
• Investigators: Principal Investigator: Corinne BLANCHET, APHP - Cochin hospital

Publications and helpful links

General Publications

• Battle DE. Diagnostic and Statistical Manual of Mental Disorders (DSM). Codas. 2013;25(2):191-2. doi: 10.1590/s2317-17822013000200017. No abstract available.
• Gorwood P, Blanchet-Collet C, Chartrel N, Duclos J, Dechelotte P, Hanachi M, Fetissov S, Godart N, Melchior JC, Ramoz N, Rovere-Jovene C, Tolle V, Viltart O, Epelbaum J. New Insights in Anorexia Nervosa. Front Neurosci. 2016 Jun 29;10:256. doi: 10.3389/fnins.2016.00256. eCollection 2016.
• Schoen SA, Miller LJ, Green KE. Pilot study of the Sensory Over-Responsivity Scales: assessment and inventory. Am J Occup Ther. 2008 Jul-Aug;62(4):393-406. doi: 10.5014/ajot.62.4.393.

Helpful Links

• LEBLANC V, LECOUFLE A, BOURGEOIS C, al et. Boîte à idées pour oralité malmenée du jeune enfant [Internet]. Nutricia; s. d. 19 p

Study record dates

Study Major Dates

• Study Start (ACTUAL): November 30, 2021
• Primary Completion (ACTUAL): March 24, 2022
• Study Completion (ACTUAL): March 24, 2022

Study Registration Dates

• First Submitted: September 27, 2021
• First Submitted That Met QC Criteria: October 11, 2021
• First Posted (ACTUAL): October 25, 2021

Study Record Updates

• Last Update Posted (ACTUAL): June 30, 2022
• Last Update Submitted That Met QC Criteria: June 29, 2022
• Last Verified: June 1, 2022

More Information

Terms related to this study

• Keywords: anorexia nervosa; Avoidant/Restrictive Food Intake Disorder; sensory integration; Restrictive eating disorder; sensory modulation disorder; sensory modulation symptoms; sensory over responsivity
• Additional Relevant MeSH Terms: Mental Disorders; Pathologic Processes; Disease; Feeding and Eating Disorders; Avoidant Restrictive Food Intake Disorder
• Other Study ID Numbers: APHP211140; 2021-A01755-36 (OTHER: France : ANSM)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No