- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05812092
Treatment of One and/or Two Level Cervical Degenerative Disc Disease
A Prospective Clinical/Radiological Outcome Study of the CONDUIT™ Interbody Cervical System With Supplemental Fixation for the Treatment of One and/or Two Level Cervical Degenerative Disc Disease and/or Cervical Spinal Instability
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Locations
-
-
Texas
-
Fort Worth, Texas, United States, 76132
- DFW Center for Spinal Disorders
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Male or female subject; at least 18 years of age
Diagnosis of radiculopathy or myelopathy with radiculopathy of the cervical spine, with pain, paresthesias or paralysis in a specific nerve root distribution C2 through T1, including at least one of the following:
- Neck and/or arm pain of at least 30/100 mm on the visual analogue scale (VAS) scale
- Decreased muscle strength of at least one level on the clinical evaluation (0 to 5) scale
- Abnormal sensation including hyperesthesia or hypoesthesia; and/or
- Abnormal reflexes
- Symptomatic cervical disc disease, facet arthropathy, or cervical spinal stenosis at 1 or 2 levels between C2 and T1, suitable for treatment with anterior discectomy, decompression, and fusion
Radiographically determined pathology at the level to be treated correlating to primary symptoms including at least one of the following:
- Decreased disc height on radiography,) in comparison to a normal adjacent disc
- Degenerative spondylosis
- Disc herniation
- NDI Score >30%.
Unresponsive to non-operative, conservative treatment (rest, heat, electrotherapy, physical therapy, chiropractic care and/or analgesics) for:
- Approximately six weeks from radiculopathy or myelopathy with radiculopathy symptom onset; or
- Have the presence of symptoms or signs of nerve root/spinal cord compression despite continued non-operative, conservative treatment; or
- Sooner than 6 weeks for worsening symptoms of neurologic compromise.
- Reported to be medically cleared for surgery.
- Physically and mentally able and willing to comply with the Protocol, including the ability to read and complete required forms and willing and able to adhere to the scheduled follow-up visits and requirements of the Protocol.
- Signed informed consent provided by subject.
Exclusion Criteria:
- Have an active systemic infection or infection at the operative site.
- Have a history of or anticipated treatment for active systemic infection, including HIV or Hepatitis C.
- Have previous trauma to the C2 to T1 levels resulting in significant bony or disco- ligamentous cervical spine injury.
- Have had any prior spine surgery at the operative level(s).
- Have osteoporosis
- Have Paget's disease of bone, osteomalacia or any other metabolic bone disease other than osteoporosis (addressed above).
- Have active malignancy that included a history of any invasive malignancy (except non- melanoma skin cancer),unless the subject had been treated with curative intent and there had been no clinical signs or symptoms of the malignancy for at least five years.
- Have symptomatic cervical disc disease or significant cervical spondylosis at more than 2 levels.
- Have a known allergy to titanium.
- Are currently pregnant or breastfeeding at time of enrollment or have plans to become pregnant within the next three years.
- Have rheumatoid arthritis, lupus, or other autoimmune disease affecting the musculoskeletal system
- Have diseases or conditions that would preclude accurate clinical evaluation in the opinion of the Investigator
Have concomitant conditions requiring daily, high-dose oral and/or inhaled steroids.
High dose steroid use is defined as:
- Daily, chronic use of oral steroids equivalent to 5 mg/day of prednisone or greater.
- Daily, chronic use of inhaled corticosteroids (at least twice per day).
- Use of short-term (less than 10 days) oral steroids at a daily dose greater than 40mg prednisone equivalent within one month of the study procedure.
- Have current or recent history (within 1 year prior to screening) of substance abuse (alcoholism and/or narcotic addiction) requiring intervention.
- Have a Body Mass Index (BMI) > 40 kg/m2.
- Taking medications known to potentially interfere with bone/soft tissue healing (e.g., high-dose oral and/or inhaled steroids, immunosuppressant medication, chemotherapeutic agents). High dose steroid use as defined in Exclusion Criterion 13.
- Have pending personal litigation relating to spinal injury (worker's compensation is not an exclusion).
- Have a current history of heavy smoking (more than one pack of cigarettes per day).
- Currently reside in a location, or anticipating a potential relocation, that may interfere with completion of follow-up examinations.
- Have mental illness or belonged to a vulnerable population, as determined by the investigator (e.g., prisoner or developmentally disabled), that would compromise ability to provide informed consent or compliance with follow-up requirements.
- Have an uncontrolled seizure disorder.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
DePuy Synthes Cervical Plating System
All enrolled patients will receive CONDUIT Interbody Cervical System with supplemental fixation using a DePuy Synthes Cervical Plating System.
|
CONDUIT Interbody Cervical System will be inserted between C2 through T1 and fixated using a DePuy Synthes Cervical Plating System at 1 or 2 levels.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Primary Outcome Measure:
Time Frame: 12 months
|
Number of participants with a 15% improvement in NDI score (based on 100% scale) compared to baseline
|
12 months
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- ONRI-OP-001
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
product manufactured in and exported from the U.S.
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Cervical Radiculopathy
-
Riphah International UniversityRecruitingCervical Radiculopathy | CervicalPakistan
-
Cairo UniversityCompletedCervical Radiculopathy | Disc Herniation | Cervical Radiculopathy at C5 Nerve Root | Cervical Radiculopathy at C6 Nerve Root | Cervical Radiculopathy at C7 Nerve RootEgypt
-
William Beaumont HospitalsCamber Spine TechnologiesTerminatedCervical Radiculopathy | Cervical Disc DiseaseUnited States
-
Gazi UniversityRecruitingCervical Radiculopathy | Cervical Radicular Pain | Cervical Radiculitis | Cervical Root SyndromeTurkey
-
Valérie SchuermansRecruitingCervical Disc Disease | Cervical Fusion | Fusion of Spine | Cervical Spondylosis | Cervical Disc Herniation | Myelopathy Cervical | Cervical Disc Degeneration | Radiculopathy, Cervical | Myelopathy, Compressive | Radiculopathy, Cervical Region | Radiculopathy; in Spondylosis | Radiculopathy; in Intervertebral... and other conditionsNetherlands
-
Marmara UniversityNot yet recruiting
-
Linkoeping UniversityRecruitingCervical RadiculopathySweden
-
Oslo University HospitalActive, not recruiting
-
Cairo UniversityUnknownCervical Radiculopathy
-
Isra UniversityUnknown
Clinical Trials on CONDUIT Interbody Cervical System with DePuy Synthes Cervical Plating System
-
ReVivo Medical, Corp.The Cleveland Clinic; Albany Medical College; IGEARecruitingNeck Pain | Spondylosis | Spondylosis With Myelopathy | Spondylosis With Radiculopathy | Spondylosis With Radiculopathy Cervical Region | Intervertebral Disc Disorder CervicalUnited States
-
University of KentuckyRecruitingSpinal Fusion | Spondylolisthesis | Arthrodesis | Pseudarthrosis | Lumbar FusionUnited States
-
Aurora Spine and PainRecruitingDegenerative Disc DiseaseUnited States
-
Seton Healthcare FamilyCompletedDegenerative Disc Disease | Spondylolisthesis | Trauma (Including Fractures)United States
-
William Beaumont HospitalsDePuy SynthesActive, not recruitingDegenerative Disc Disease | Lumbar Spinal Stenosis | Lumbar Spondylolisthesis | Lumbar Radiculopathy | Lumbar Disc Disease | Degenerative SpondylolisthesisUnited States
-
Medtronic Spinal and BiologicsCompletedRadiculopathy | Myelopathy | Cervical Degenerative Disc DiseaseUnited States
-
Mansoura UniversityUnknown
-
University Hospitals, LeicesterCompletedWhiplash Associated DisorderUnited Kingdom
-
Taipei Medical University WanFang HospitalUnknownCervical Radiculopathy | Radicular Pain | Acute Neck Pain | Cervicobrachial PainTaiwan