- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT06203314
Epstein-Barr Virus and Cancer Risks (EBVCR)
Prospective Cohort Study on Epstein-Barr Virus Antibody and Cancer Risks
The goal of this prospective cohort study is to investigate the associations between Epstein-Barr Virus (EBV) antibody levels and the risk of overall and site-specific cancer types in Southern China. The main questions it aims to answer are:
Question 1: In addition to the established EBV-associated cancer types, such as lymphomas, nasopharyngeal carcinoma, and stomach cancer, whether EBV is associated with other cancer types? Question 2: What's the cancer burden attributed to EBV in Southern China?
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Estimated)
Contacts and Locations
Study Contact
- Name: Wei-Hua Jia
- Phone Number: 86+020-87342327
- Email: jiawh@sysucc.org.cn
Study Contact Backup
- Name: Yong-Qiao He
- Phone Number: 86+020-87342410
- Email: heyq@sysucc.org.cn
Study Locations
-
-
Guangdong
-
Zhongshan, Guangdong, China, 528403
- Recruiting
- Zhongshan People's Hospital
-
Contact:
- Ming-Fang Ji
- Phone Number: 86+0760-88822698
- Email: jmftbh@sina.com
-
Principal Investigator:
- Ming-Fang Ji
-
-
Guangxi
-
Wuzhou, Guangxi, China, 543002
- Recruiting
- Wuzhou Red Cross Hospital
-
Contact:
- Min-Zhong Tang
- Phone Number: 86+0774-3849595
- Email: gxtom@163.com
-
Principal Investigator:
- Min-Zhong Tang
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Subject residents in Zhongshan or Wuzhou City;
- Subject has no medical record of prevalent cancer;
- Subject has psychical condition and well consciousness, and willingness to accept and cooperate with the study's follow-up procedures.
Exclusion Criteria:
- Subject has heavy cardiovascular, liver, or kidney disease;
- Subject has prevalent cancer.
Study Plan
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
Zhongshan cohort, Guangdong, China
30-59 years old healthy participants in Zhongshan city.
|
Participants underwent several EBV antibody tests, including VCA-IgA, EBNA1-IgA, etc.
|
Wuzhou cohort, Guangxi, China
30-69 years old healthy participants in Wuzhou city.
|
Participants underwent several EBV antibody tests, including VCA-IgA, EBNA1-IgA, etc.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cancer incidence
Time Frame: 10 years
|
The primary outcome of the study was the diagnosis of any type of cancer.
The cancer type for each participant was defined as their initial and primary cancer diagnosis.
|
10 years
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
All-cause mortality
Time Frame: 10 years
|
The participants were followed up annually for cancer incidence, vital status and immigration status through the Cancer Registry, Death Registry, and Population Registry of local regions.
|
10 years
|
Collaborators and Investigators
Sponsor
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- EBV-PRO-001
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
IPD Plan Description
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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