- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT00555542
An Analysis of Peripheral Blood T Cell Subsets on Rheumatoid Arthritis
7. maj 2008 opdateret af: Chinese University of Hong Kong
B Cell Depletion Therapy in Rheumatoid Arthritis: An Analysis of Peripheral Blood T Cell Subsets
To study the effects of T cell in peripheral blood of patients with RA undergoing selective B cell depletion have not been studied.
We analyze the B and T cell subsets in patients with active RA treated undergoing this form of treatment with rituximab.
Studieoversigt
Detaljeret beskrivelse
- In this open labeled prospective study, we evaluate the therapeutic efficacy and peripheral blood cellular response of rituximab in 10 patients with active RA despite conventional DMARDs therapy.
- Patients are taking stable dose of methotrexate and at least 10mg folic acid per week for at least 4 weeks. Rituximab is administrated as 1000mg intravenous infusion on day 1 and day 15. Premedication as standard prescription consists of methylprednisolone 100mg IV, Chlorpheniramine maleate(piriton 10mg IV and oral paracetamol 500mg to be given 30 minutes before each infusion of rituximab. Oral prednisolone 60mg is tob e given from day 1-6 after rituximab infusion and 30mg from day 7-13.
In patients who relapses following the first cycle can be repeated with the second cycle must fulfill the following conditions:
- Patients must have responded clinically to the first infusion with improvement
- Other disease modifying anti-rheumatic drugs (DMARDs) are not appropriate as determined by the investigators, either they have been on them before or are ineffective or due to side effects,
- Patients have a disease activity score DSA>2.6
- At least 24 weeks since the first infusion
- Neutrophil count of >1.5 X 103/mcL
- The second infusion consists of rituximab 1000mg intravenous infusion on day 1 and day 15 as before and the same protocol of followed up every 4 weeks up to 52 weeks from the day of the first infusion.14 Premedication as standard prescription (consists of methylprednisolone 100mg IV, Chlorpheniramine maleate(piriton) 10mg IV and oral paracetamol 500mg to be given 30 minutes before each infusion of rituximab.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
10
Fase
- Fase 2
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Hong Kong, Kina
- Department of Medicine and Therapeutics
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
21 år til 70 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Alle
Beskrivelse
Inclusion Criteria:
- Age 21 or above
- Fulfilled the 1978 American college of Rheumatology(ACR) criteria for RA
- Seropositive for RF with RF>20 IU/ml
- Active disease despite treatment with at least 2 stable dose of DMARDs for at least 16 weeks, including MRX>10mg weekly
- 4 or more swollen and/or tender joints
- Stable dose of prednisolone<=12.5mg/day or NASID for at lease 4 weeks
- MTX>10mg/wk and folic acid>10 mg/wk for at lease 4 weeks
Exclusion Criteria:
- Little or no ability for self-care
- Used a DMARD other than MTX(Leflunomide should be wash-out with cholestyramine 4 weeks prior screening)
- Received intra-articular,intramuscular, or intravenous corticosteroids in the last 4 weeks
- Concurrent treatment with any biologics within 8 weeks
- Infected joint prosthesis during the previous 5 years
- Autoimmune disease other than RA(except concurrent Sjogren's syndrome), active rheumatoid vasculitis, and history of systemic disease associated with arthritis, chronic fatigue syndrome.
- Serious infections, such as hepatitis, pneumonia, pyelonephritis in the previous 3 months
- Any chronic infectious disease such as renal infection, chest infection with bronchiectasis or sinusitis
- Recurrent bacterial infections with encapsulated organisms, primary or secondary immunodeficiency
- Active tuberculosis requiring treatment within the previous 3 years
- Opportunistic infection such as herpes zoster within the previous 2 months
- Any evidence of active cytomegalovirus;active Pneumocystis Jirovecl;or drug-resistant atypical mycobacterial infection
- Known hypersensitivity to murine proteins
- Current signs or symptoms of severe,progressive,or uncontrolled renal,hepatic,haematological,gastrointestinal,endocrine,pulmonary,cardias,neurological,or cerebral disease
- A history of lymphoproliferative disease including lymphoma or signs suggestive of disease,such as lymphadenopathy of unusual size or location(ie,lymphadenopathy nodes,in the posterior tangle of the neck,infraclavicular epitrochlear,or periaortic areas);splenomegaly
- Any know malignant disease except basal cell carcinoma currently or in the last 5 years
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: N/A
- Interventionel model: Enkelt gruppeopgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
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Eksperimentel: 1
Rituximab is administrated as 1000mg intravenous infusion on day 1 and day 15.
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Patients are taking stable dose of methotrexate and at least 10mg folic acid per week for at least 4 weeks.
Rituximab is administrated as 1000mg intravenous infusion on day 1 and day 15.
Premedication as standard prescription consists of methylprednisolone 100mg IV, Chlorpheniramine maleate(piriton 10mg IV and oral paracetamol 500mg to be given 30 minutes before each infusion of rituximab.
Oral prednisolone 60mg is tob e given from day 1-6 after rituximab infusion and 30mg from day 7-13.
Andre navne:
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
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The proportion of patients who achieved a response according to the ACR 20 response criteria at 24 weeks and 54 weeks after the initial infusion
Tidsramme: wk52
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wk52
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Sekundære resultatmål
Resultatmål |
Tidsramme |
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The proportion of patients who achieved a response according to ACR50,ACR70, physician's assessment of disease activity,patient's assessment of physical function by means of a health-assessment questionnaire(HAQ),quality of life measure by SF-36
Tidsramme: wk52
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wk52
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. juli 2006
Primær færdiggørelse (Faktiske)
1. maj 2008
Studieafslutning (Faktiske)
1. maj 2008
Datoer for studieregistrering
Først indsendt
7. november 2007
Først indsendt, der opfyldte QC-kriterier
7. november 2007
Først opslået (Skøn)
8. november 2007
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
9. maj 2008
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
7. maj 2008
Sidst verificeret
1. maj 2008
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- RA-2006-005
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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