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Transvaginal NOTES Cholecystectomy: Phase I/II Mexico Clinical Trial

14. december 2009 opdateret af: Universidad Juárez del Estado de Durango

Transvaginal Natural Orifice Translumenal and Endoscopic Surgery (NOTES) Cholecystectomy vs. Laparoscopic Cholecystectomy: Phase I/II Clinical Trial

Cholecystectomy is one of the most common general surgery procedures performed in the US today and is among top 10 procedures performed in U.S. hospitals annually, and biliary tract disease has been estimated to cost U.S. healthcare $5 billion/year. Laparoscopic cholecystectomy was introduced in the early 1990s and has become the standard surgical approach for the treatment of gallbladder disease. More than 500,000 cholecystectomy procedures are performed in the US every year. Laparoscopic cholecystectomy is now performed as an outpatient basis and is related to a very low complication rate. Laparoscopic cholecystectomy requires the use of multiple trocar incisions.

Natural Orifice Translumenal Endoscopic Surgery(NOTES) is a new type of surgical procedure currently being studied around the world. The idea of NOTES was developed several years ago in response to the concepts that patients would

  1. realize the benefits of less invasive surgery by reducing the recovery time,
  2. experience less physical discomfort associated with traditional procedures
  3. have virtually no visible scarring following this type of surgery.

All of these advantages have spurred research and investigation forward, encouraging physicians and researchers to develop new equipment and techniques to use during NOTES procedures. Although the Natural Orifice Translumenal Endoscopic Surgery approach may hold tremendous potential, there are many issues that need to be addressed before this technique is introduced into clinical care.

The purpose of this study is to determine the safety, feasibility and short-term clinical outcomes (Phase I trial) of transvaginal NOTES cholecystectomy in female patients with symptomatic cholelithiasis and compare it to Laparoscopic Cholecystectomy (Phase II).

Hypothesis 1: Transvaginal NOTES cholecystectomy is safe and feasible in female patients with symptomatic cholelithiasis.

Hypothesis 2: The short term outcomes of Transvaginal NOTES cholecystectomy are comparable to Laparoscopic Cholecystectomy in female patients with symptomatic cholelithiasis.

Aim 1: Determine the safety of Transvaginal NOTES cholecystectomy. Aim 2: Determine the feasibility of Transvaginal NOTES cholecystectomy. Aim 3: Determine the short-term outcomes of Transvaginal NOTES cholecystectomy. Aim 4: Compare the short-term outcomes of Transvaginal NOTES cholecystectomy to Laparoscopic cholecystectomy.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Most recently, surgeons and endoscopists have focused on NOTES cholecystectomy. Access to the abdominal cavity to perform NOTES procedures has been obtained by transgastric, transvaginal, transvesical and transrectal approaches. The first successful NOTES procedure in humans was an appendectomy in India. Transvaginal NOTES cholecystectomy has been successfully performed and reported in a handful of cases in the US, Europe and South America. However, to date, there is lack of clinical trials that demonstrate the safety and feasibility of Transvaginal NOTES cholecystectomy in a larger group of patients.

Undersøgelsestype

Interventionel

Tilmelding (Forventet)

40

Fase

  • Fase 2
  • Fase 1

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Mexico
      • Durango, Mexico, 34000
        • Universidad Juarez del Estado de Durango, Mexico

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 65 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Kvinde

Beskrivelse

Inclusion Criteria:

  1. Adult (> 18 years old) female patients residents of Durango Mexico.
  2. Patients who undergo elective surgery.
  3. Patients with ultrasound documented symptomatic cholelithiasis, gallbladder polyps of biliary dyskinesia.
  4. Patients capable of giving written informed consent for the study.

Exclusion Criteria:

  1. Patients who have contraindications prohibiting general anesthesia.
  2. Pregnancy.
  3. Previous abdominal or gynecological procedures.
  4. Uncontrollable medical or psychiatric conditions
  5. Elderly > 65 y/o.
  6. Body Mass Index > 35 mg/kg2.
  7. Complicated or acute cholecystitis.
  8. Elevation of liver function tests.
  9. Acute abdomen.
  10. Intra-abdominal abscess.
  11. Coagulopathy.
  12. Imperforated hymen.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: 1
Transvaginal NOTES Cholecystectomy (Phase 1)
Procedure: Transvaginal NOTES cholecystectomy
Under general anesthesia, patients will undergo Transvaginal NOTES cholecystectomy
Andre navne:
  • NOTES gallbladder removal
  • NOTES gallbladder surgery
Aktiv komparator: 2
Laparoscopic Cholecystectomy (Phase 2)
Procedure: Laparoscopic cholecystectomy
Under general anesthesia, patients will undergo standard Laparoscopic cholecystectomy
Andre navne:
  • Small incision gallbladder surgery
Eksperimentel: 3
Transvaginal NOTES cholecystectomy (Phase 2)
Procedure: Transvaginal NOTES cholecystectomy
Under general anesthesia, patients will undergo Transvaginal NOTES cholecystectomy
Andre navne:
  • NOTES gallbladder removal
  • NOTES gallbladder surgery

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Tidsramme
Safety and Efficacy of Transvaginal NOTES cholecystectomy when compared to Laparoscopic cholecystectomy
Tidsramme: 12 months
12 months

Sekundære resultatmål

Resultatmål
Tidsramme
Short term outcomes of Transvaginal NOTES cholecystectomy when compared to Laparoscopic Cholecystectomy
Tidsramme: 12 months
12 months

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Universidad Juárez del Estado de Durango

Samarbejdspartnere

Hospital Universitario La Paz

Efterforskere

  • Ledende efterforsker: Homero Rivas, MD, Hospital de la Paz

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. januar 2009

Primær færdiggørelse (Faktiske)

1. december 2009

Studieafslutning (Faktiske)

1. december 2009

Datoer for studieregistrering

Først indsendt

2. juli 2008

Først indsendt, der opfyldte QC-kriterier

2. juli 2008

Først opslået (Skøn)

4. juli 2008

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Skøn)

15. december 2009

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

14. december 2009

Sidst verificeret

1. december 2009

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 05626

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Kolelithiasis

Kliniske forsøg med Transvaginal NOTES cholecystectomy

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Croatia

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

3
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