- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT01229189
Evaluation of the Effectiveness of Vitamin D Supplementation to Pregnant Women and Their Infants in Pakistan.
Evaluation of the Effectiveness of Vitamin D Supplementation to Pregnant Women and Their Infants in Pakistan
Vitamin D deficiency is wide spread in South Asian population and is contributing to burden of disease in this region including Pakistan. The relative importance of vitamin D deficiency, mutation in its receptor and maternal and child health has not been established in Pakistan and population based studies are required to explore and avert the maternal and Neonatal complications and consequences of Vitamin D deficiency
The trial will evaluate the effectiveness of Vitamin D supplementation to pregnant women and their Infants. It will be a double blind placebo controlled trial, which will be conducted in a rural district of Pakistan.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
The investigators are proposing a community based introduction of vitamin D supplementation and we intend to understand the complex relationship between vitamin D, the growth factors and maternal and infant anthropometric variables and hope to unravel the reasons of vitamin D deficiency in our population.
The investigators expect that if vitamin D is supplemented to pregnant women and their newborn infants it will inevitably replenish the micronutrient stores and aid to resolve the maternal and neonatal morbidity due to Vitamin D deficiency.
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Ikke anvendelig
Kontakter og lokationer
Studiesteder
-
-
Punjab
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Pind Dadan Khan, Punjab, Pakistan, 49040
- Project Office Aga Khan University
-
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Pregnant women from 20-22 weeks of gestation and their infants, who will agree to take part in this study, will be enrolled.
Exclusion Criteria:
- Pregnant women with pre existing type 1 or type II diabetes
- Women with multiple fetuses, babies (twins, triplets)
- Pregnant women with high level of Vitamin D
- Babies with multiple congenital anomalies
- Babies with serious birth injury, birth asphyxia and serious infections
- Low birth weight less than 1.5
- Refuse to participate in the study
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Sundhedstjenesteforskning
- Tildeling: Randomiseret
- Interventionel model: Enkelt gruppeopgave
- Maskning: Firedobbelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Eksperimentel: Maternal and Neonatal Intervention Arm
Pregnant women will be individually randomized; a daily dose of vitamin D in 4000 IU will be given to Intervention group, started at 20-22 weeks of pregnancy till the time of delivery.
The infants of this group will further stratify into two groups, one group will receive 400 IU of Vitamin D for 6 months as Intervention.
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Maternal dose of 4000 IU daily for 20 weeks Neonatal dose of 400 IU daily for 24 weeks
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Placebo komparator: Maternal and Neonatal Control Arm
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Placebo will be supplemented to pregnant women and their neonates in the same pattern as in intervention group.
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Maternal and Neonatal complications
Tidsramme: six months post enrolement
|
Preeclampsia, hypertension ,poor weight gain etc during pregnancy.Still birth rates, Rate of low birth weight, prematurity,Neonatal seizures, Infants with growth failure, signs and symptoms of vitamin D deficiency.
Infants with infections: pneumonia, diarrhea and Receptor polymorphism
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six months post enrolement
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Sekundære resultatmål
Resultatmål |
Tidsramme |
---|---|
Prevalence and Risk factors for Maternal and Neonatal Vit D Deficiency
Tidsramme: Six months post recruitment
|
Six months post recruitment
|
Samarbejdspartnere og efterforskere
Sponsor
Samarbejdspartnere
Publikationer og nyttige links
Hjælpsomme links
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Patologiske processer
- Ernæringsforstyrrelser
- Kropsvægt
- Avitaminose
- Mangelsygdomme
- Fejlernæring
- Graviditetskomplikationer
- Død
- Hypertension, graviditetsinduceret
- Fosterdød
- D-vitamin mangel
- Fødselsvægt
- Eklampsi
- Præeklampsi
- Dødfødsel
- Lægemidlers fysiologiske virkninger
- Mikronæringsstoffer
- Vitaminer
- Knogletæthedsbevarende midler
- D-vitamin
Andre undersøgelses-id-numre
- Vitamin D Study
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