Gene x Behavior Interaction in the Look AHEAD Study

Gene x Behavior Interaction in the Look AHEAD Study

Patrocinadores

Patrocinador principal: The Miriam Hospital

Colaborador: Tufts Medical Center
Brown University

Fuente The Miriam Hospital
Resumen breve

The interplay of genetic and behavioral factors is critical to understanding obesity. Behavioral weight loss intervention has emerged as a key strategy in combating obesity. However, individuals differ in their degree of success in these programs and genetic factors are known to play a role. In this application, the investigators propose to identify specific genes that predict individual differences in weight loss and high density lipoprotein cholesterol in response to behavioral intervention to help identify individuals that struggle with weight loss and cholesterol despite behavioral efforts.

Descripción detallada

The interplay of genetic and behavioral factors is critical to understanding obesity. Obesity is a major public health problem, with millions of Americans suffering from weight-related health complications, including Type 2 diabetes, coronary heart disease, hypertension, and osteoarthritis. Behavioral weight loss intervention has emerged as a key strategy in combating obesity and the associated health consequences. However, individuals differ in their degree of success in these programs even if they make the recommended behavioral changes and genetic factors are known to play a role. In this application, the investigators propose to identify specific genes that predict individual differences in weight loss in response to behavioral intervention to help identify individuals who struggle with weight loss despite behavioral efforts. Specifically, the investigators will determine whether obesity genes interact with lifestyle intervention in predicting weight loss at year 1 of the Look AHEAD trial, an NIH-funded, multi-center randomized controlled trial with the primary goal of determining whether weight loss achieved through an intensive lifestyle intervention can reduce cardiovascular morbidity and mortality among persons with type 2 diabetes. At year 1, participants assigned to Intensive Lifestyle Intervention (ILI), focusing on changes in diet and physical activity, lost an average of 8.6% of their weight (N = 2,496; 97.1% follow-up) relative to losses of 0.7% among individuals assigned to the Diabetes Support and Education (DSE) group (N= 2,463, 95.7% follow-up), who received diabetes support and education groups alone. Consent for genetic analyses was provided by 3,759 participants. Genotype data from the IBC chip, a genotyping platform including 50,000 single nucleotide polymorphisms (SNPs) from ~2,600 genes relevant to cardiovascular disease, lipid metabolism, diabetes and obesity, will allow us to test the central hypothesis that genes that predispose to obesity interact with lifestyle treatment to influence weight loss following intensive lifestyle intervention. The investigators will also determine whether genes related to high density lipoprotein (HDL) cholesterol predict the degree of improvement in HDL in response to the behavioral intervention. The investigators conduct these aims with the explicit goal of bringing together a team with expertise in behavioral research, genetic epidemiology and molecular biology to create transdisciplinary researchers who are able to bridge across the disciplines and identify key gene x behavior interactions in the context of the Look AHEAD trial.

Estado general Completed
Fecha de inicio July 2009
Fecha de Terminación March 2015
Fecha de finalización primaria March 2015
Tipo de estudio Observational
Resultado primario
Medida Periodo de tiempo
Body weight 4 years
High density lipoprotein cholesterol 4 years
Resultado secundario
Medida Periodo de tiempo
Dietary intake 4 years
Physical activity/fitness 4 years
Inscripción 4108
Condición
Intervención

Tipo de intervención: Behavioral

Nombre de intervención: Intensive lifestyle intervention

Descripción: Lifestyle intervention focused on weight loss through diet and physical activity

Etiqueta de grupo de brazo: The Look AHEAD Study

Tipo de intervención: Behavioral

Nombre de intervención: Diabetes support and education

Descripción: Behavioral intervention focused on diabetes support and education

Etiqueta de grupo de brazo: The Look AHEAD Study

Elegibilidad

Método de muestreo: Non-Probability Sample

Criterios:

Inclusion Criteria:

- Enrollment in the Look AHEAD Study, genetic consent

Género: All

Edad mínima: 45 Years

Edad máxima: 74 Years

Voluntarios Saludables: No

Oficial general
Ubicación
Instalaciones: The Miriam Hospital
Ubicacion Paises

United States

Fecha de verificación

March 2015

Fiesta responsable

Tipo: Principal Investigator

Afiliación del investigador: The Miriam Hospital

Nombre completo del investigador: Jeanne McCaffery

Título del investigador: Senior Research Scientist/Associate Professor

Palabras clave
Tiene acceso ampliado No
Condición Examinar
Grupo de brazo

Etiqueta: The Look AHEAD Study

Descripción: The Look AHEAD Study includes intensive lifestyle intervention treatment, focusing on caloric intake and physical activity, and a treatment arm focused on diabetes support and education.

Información de diseño del estudio

Modelo de observación: Cohort

Perspectiva de tiempo: Prospective

Fuente: ClinicalTrials.gov