Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Esophageal Cancer

DISEASE CHARACTERISTICS:

• Histologically confirmed squamous cell carcinoma or adenocarcinoma of the esophagus or gastroesophageal junction

  • T1, N1, M0 or T2-4, Nx, M0

    • No supraclavicular or celiac lymph nodes
• Previously untreated, newly diagnosed tumors OR

• Prior resection without adjuvant therapy with local regional failure

  • Positive microscopic margin on resection of all gross disease allowed provided no metastatic disease
• No positive malignant cytology of the pleura, pericardium, or peritoneum
• No biopsy proven tumor invasion of the tracheobronchial tree or tracheoesophageal fistula

PATIENT CHARACTERISTICS:

Age:

• 18 and over

Performance status:

• Karnofsky 70-100% OR
• ECOG 0-2

Life expectancy:

• Not specified

Hematopoietic:

• Absolute neutrophil count greater than 1,500/mm^3
• Platelet count at least 100,000/mm^3
• Hemoglobin at least 9.0 g/dL

Hepatic:

• Bilirubin no greater than 1.5 mg/dL
• No known Gilbert's disease

Renal:

• Creatinine no greater than 1.5 mg/dL
• No hypercalcemia

Cardiovascular:

• No New York Heart Association class III or IV heart disease
• No myocardial infarction within the past 6 months
• No uncontrolled hypertension

Other:

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No other severe concurrent conditions (e.g., severe uncontrolled diabetes, uncontrolled infections, or cerebral vascular disease)
• No other malignancy within the past 5 years except basal cell carcinoma of the skin or carcinoma in situ of the cervix
• No history of seizure disorder currently receiving phenytoin, phenobarbital, or other antiepileptic medication
• No other concurrent medical or psychiatric condition or disease that would preclude study entry

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• No prior chemotherapy for esophageal cancer including adjuvant chemotherapy

Endocrine therapy:

• Not specified

Radiotherapy:

• No prior radiotherapy for esophageal cancer including adjuvant radiotherapy
• No prior mantle, chest, pelvic, or hemibody radiotherapy

Surgery:

• See Disease Characteristics

Other:

• No concurrent prochlorperazine on day of irinotecan administration