Feasibility Study of Ablathermy Focused Ultrasound (USF) of Breast Tumors Before Mastectomy (USF)

Inclusion Criteria:

• Invasive Breast Carcinoma with histologically confirmed hormone receptor analysis, the grade of the tumor, the expression of Her-2.
• Lesion classified T1-T2-T3 unifocal or multifocal with or without associated microcalcifications
• Lesion recognizable and identifiable in MRI
• Indication of mastectomy with or without axillary
• Lesion located more than 10 mm from the skin, the nipple and pectoralis major
• No cons-indication to MRI (pacemaker)
• Women whose age is ≥ 18 years
• If premenopausal patient: patient contraceptives
• Patient has signed informed consent
• Affiliation to a social security scheme

Exclusion Criteria:

• Tumor-TD T4B classified or non-palpable lesion
• If age <70 years: no indication of adjuvant chemotherapy and neoadjuvant
• MRI lesions have not been identified, located within 10 mm of the skin and pectoral muscle, greater than 25 mm diameter
• Inability to hold still in the prone position, arms extended, for 30 minutes
• Contraindication to MRI
• Patient deprived of liberty and major subject of a measure of legal protection or unable to consent
• Patient participating in another interventional clinical trial within 30 days prior to baseline and during the trial.