Prognostic Value of Tissue Factor (TF) in Blood t in Colorectal Cancer in Adults (TF)
Severity of colorectal cancer (CRC) is evaluated by its local staging, locoregional and general ( presence of metastases , usually liver ). This is the most common cancer in France and, despite surgical treatment of the primary tumor, it is still subject to a high mortality rate due to metastatic evolution, mainly hepatic .
There is currently no specific marker for predicting cancer, the same hardly changed , which would modulate the aggressive therapeutic strategy . antigen (CEA) is used in the monitoring of JRC made.Tissue factor (TF) is the VII tissue factor receptor. it initiates the coagulation cascade. it was noted as a true cell marker tumorale1 aggressiveness. Corroborating evidence that the way the TF plays an important role in the invasive and metastatic potential of CRC. First, various human cancer cell lines express the FT colic. Furthermore, there is a relationship between the importance of monocyte TF expression and the evolutionary potential of human CRC.
The investigators hypothesize that these interest intra-platelet and plasma markers are a reflection of tumor angiogenic potential. And the investigators will verify the superiority of their preoperative levels in the CRC group compared with the control group, normalization of postoperative after surgical resection rates and their possible re-ascent in case of tumor recurrence in the CRC group.
The levy to one month in controls allow us to verify the absence of secondary modification to laparotomy, the colectomy and general anesthesia.
The investigators assume that the rate of soluble TF in peripheral blood of the holders of CRC patients may be a marker of invasion and aggression (i.e. prognosis).
研究概览
详细说明
研究类型
注册 (预期的)
阶段
- 第一阶段早期
联系人和位置
学习联系方式
- 姓名:ZERBIB Philippe, Professeur
- 电话号码:+00333 20 44 44 64
- 邮箱:p-zerbib@chru-lille.fr
研究联系人备份
- 姓名:LOUNI Chanaz, CRA
- 电话号码:+0033320414445
- 邮箱:chanaz.louni@chru-lille.fr
学习地点
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-
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Lille、法国、59037
- 招聘中
- Service de Chirurgie Digestive et de transplantation Hôpital Claude HURIEZ
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接触:
- ZERBIB Philippe, Prof
- 电话号码:03 20 44 44 64
- 邮箱:p-zerbib@chru-lille.fr
-
-
参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
All patients, adults, holders of CRC with or without MH in whom surgical resection HEALING is planned .
For witnesses:
- Patients without CCR (preoperative colonoscopy). This control population will verify normal values regulators of angiogenesis recently defined and specificity of these vis-à-vis markers CCR-
Exclusion Criteria:
all situations where the plasma levels of FT antigen are high, in particular:
- Patients with unstable angina or myocardial infarction in the acute phase (not older than two months)
- Severe sepsis (hospitalization)
- Cirrhosis stage Child C
- Chronic renal failure requiring renal replacement extra
- Patients with microvascular complications of diabetes
- Vasculitis
Pregnancy and lactation patient on oral contraceptives, or having hormone replacement therapy for menopause
- Patients with extrahepatic metastases
- Patients underwent emergency surgery
- Persons not able to consent
For witnesses:
History of cancer, inflammatory disease, diabetes, regular intake of anti inflammatory drugs.
If during colonoscopy, colorectal cancer was detected, the control patients were excluded from the study -
学习计划
研究是如何设计的?
设计细节
- 主要用途:诊断
- 分配:非随机化
- 介入模型:并行分配
- 屏蔽:无(打开标签)
武器和干预
参与者组/臂 |
干预/治疗 |
---|---|
实验性的:Group CRC
patient with a colorectal cancer
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blood samples
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实验性的:Group control
Control - volunteers
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Blood samples
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
TNM primary colorectal tumor stage
大体时间:Before surgery
|
soluble blood TNM value will be determined before surgery, and compared between groups.
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Before surgery
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
TF (blood levels of soluble TF)
大体时间:1 , 6 , 12, 18 and 24 months .5 years
|
Comparing the pre - operative and post -operative blood levels of soluble TF and TF intratumoral
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1 , 6 , 12, 18 and 24 months .5 years
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TF intratumoral (blood levels of TF intratumoral)
大体时间:1 , 6 , 12, 18 and 24 months .5 years
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Comparing the pre - operative and post -operative blood levels of soluble TF and TF intratumoral
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1 , 6 , 12, 18 and 24 months .5 years
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E- selectin and CRP
大体时间:1 , 6 , 12, 18 and 24 months. 5 years
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Comparison - soluble TF with blood levels of other circulating proteins: E- selectin and CRP at different times of follow-up.
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1 , 6 , 12, 18 and 24 months. 5 years
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ACE
大体时间:1 , 6 , 12, 18 and 24 months .5 years
|
Evaluation of the prognostic value of blood levels of soluble TF and that of ACE blood on the incidence of Metastases Hepatic in patients undergoing CRC and / or hepatic
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1 , 6 , 12, 18 and 24 months .5 years
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Interaction plate / tumor cell
大体时间:1 , 6 , 12, 18 and 24 months .5 years
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Quantifying the interaction plate / tumor cell by measuring intraplatelet regulatory proteins and angiogenesis markers of platelet activation and plasma compare the
|
1 , 6 , 12, 18 and 24 months .5 years
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合作者和调查者
调查人员
- 研究主任:ZERBIB Philippe, Prof、CHRU of Lille
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (预期的)
研究完成 (预期的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (估计)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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