- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01798199
Vanquishing Apathy Through E-inclusion Using Realistic Virtual Environment Project (VERVE)
VERVE* PROJECT: Study of the Acceptability of a Virtual Reality System on the Cognitive Stimulation of Patients With Alzheimer's Disease or Related Conditions. (*Vanquishing Apathy Through E-inclusion Using Realistic Virtual Environment)
Virtual environments and information communication technologies (ICT) offer large perspectives in the field of assistive care and rehabilitation.
As potentially endless, the scenarios and environment used using 3D can provide immersive social and interactive context for enjoyable and therapeutic exercises in the aging population. In addition it is also possible to use this type of serious game and scenario in very easy to use devices such as lap top or tablet.
Social exclusion has many causes, Apathy as one of the most common behavioural disturbances found in old adults populations alters significantly social and emotional interaction.
Even though, progress in VR has been made over the past year, the presence of such technology in daily living space is still at the embryonic stage.
The European e-Inclusion policy stresses the importance of ICT in improving the quality of life in potentially disadvantaged groups, including older people and persons.
The VERVE project is developing ICT tools to support the treatment of people who are at risk of social exclusion due to apathy associated with a disability.
As people aged and autonomy worsen fear for safety and comfortable means to maintain social and Health Related Quality of Life (HRQL) status are public health issues.
Moreover, even though older adults would like to perform some activities such as walking in the streets some are reluctant to go out of their homes as the external environment is perceived as potentially unsafe.
Apathy, the most common behavioural symptoms in aging population is characterized by symptoms of reduced initiation and responsiveness to environmental interactions. The syndrome of Apathy takes form of diminished goal-directed behaviour, characterised by emotional blunting, loss of initiative and loss of interest. Apathy along with the nosological characteristics of dementia induces impairment in autonomy level and therefore dependence as cognitive impairments worsened.
The importance of stimulation could be related to the concept of engagement defined as the act of being occupied or involved with an external stimulus. Engaging older person with or without Alzheimer's disease and related disorders in appropriate activities has been shown to yield beneficial HRQL effects such increasing positive emotion, improving cognition, functional autonomy and quality of life.
Accordingly, enriched environments with high definition virtual representation of cities and activities of interest have the potentials not only to encourage patients to get active in a safe and interactive environment but also to create access to enjoyable and stimulating settings for the more severe patients.
The VR setting from VERVE proposed personalised and populated environments available on two different, but interlinked hardware platforms: 1/: standard gaming set-up in the home, nursing home or day hospital therapy group; and 2/ mobile tracked internet devices (e.g.,IPad). The system will ensure maximum openness and dissemination by using 3D Web technologies.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Nice, France, 06000
- CHU de Nice
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Nice, France, 06000
- Ehpad Valrose
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Nice, France, 06000
- EHPAD Villa Hélios Saint Jean
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria to MILD COGNITIVE IMPAIRMENT:
- Male or Female aged ≥ 60 years.
- Subject presenting a diagnosis of MCI according to the criteria of the National Institute on Aging and Alzheimer Association group (Albert M.S., 2011) ; or Alzheimer disease at the prodromal stage (Dubois B., 2010 )
- Subject presenting a score of 0 at the " Tremor " and " Rigidity " items from the UPDRS III
- Patient not presenting a major depression episode according to the DSM IV-R;
- Be affiliate to the social security system (For French patients only);
- Case of patients under guardianship after agreement of the guardian (legal entity);
- Signed and dated a written informed consent obtained from the subject
Exclusion Criteria to MILD COGNITIVE IMPAIRMENT:
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Study Plan
How is the study designed?
Design Details
- Primary Purpose: Health Services Research
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
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Experimental: Alzheimer disease
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
the participants and careers acceptability
Time Frame: 8 weeks
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The primary objective is to evaluate the participants and careers acceptability in short and long term use of the VERVE light portable system used for cognitive stimulation of patients with cognitive pathologies.
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8 weeks
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
To assess the impact of behavioral disturbances over the use of the VR using the NPI and the Apathy Inventory
Time Frame: at 3, 4 and 8 weeks
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To assess the impact of behavioral disturbances over the use of the VR using the NPI and the Apathy Inventory
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at 3, 4 and 8 weeks
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To describe the parameters those facilitate engagement within the designs of VERVE VR setting using the engagement scale OME
Time Frame: at 1, 2, 3, a weeks
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To describe the parameters those facilitate engagement within the designs of VERVE VR setting using the engagement scale OME
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at 1, 2, 3, a weeks
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To assess the potential acceptability and preventive effectiveness of such setting in home setting using visual analogic scale and EQ-D6
Time Frame: at 3, 4, 8 weeks
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To assess the potential acceptability and preventive effectiveness of such setting in home setting using visual analogic scale and EQ-D6
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at 3, 4, 8 weeks
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To assess cognitive impact of the light VERVE setting. Using Stroop, TMT, VAT and functional task (IADL)
Time Frame: First day and 4 weeks
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To assess cognitive impact of the light VERVE setting.
Using Stroop, TMT, VAT and functional task (IADL)
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First day and 4 weeks
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Collaborators and Investigators
Investigators
- Study Director: Philippe ROBERT, PU-PH, Centre Hospitalier Universitaire de Nice
- Study Chair: Renaud DAVID, PH, CHU Nice
- Study Chair: Guillaume SACCO, PH, Centre Hospitalier Universitaire de Nice
- Study Chair: Jean Michel TURPIN, PH, Centre Hospitalier Universitaire de Nice
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 12-PP-04
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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