In-Vivo Assessment of Silver Biomaterial Nano-Toxicity 32 Ppm

Inclusion Criteria:

• 18-80 years old without debilitating chronic disease or history of cardiovascular event.

Exclusion Criteria:

• Women physically capable of becoming pregnant, who are not using 2 barrier methods of birth control;
• Any female who is nursing;
• History of heavy metal allergy;
• History of asthma or Chronic Obstructive Pulmonary Disease;
• History of renal impairment;
• Symptoms of active upper respiratory disease at time of consent;
• Smoking more than 5 cigarettes or equivalent and not able to stop for 48 hours;
• Ability to discontinue chronic medications or nutraceuticals for 20 days or 5 half-lives of the agent, whichever is longer.