A Study of Dasatinib to See How Liver Impaired and Healthy Subjects Process and React to the Study Drug

Male and Female Subjects with hepatic insufficiency conforming to Child-Pugh classification B

Male and Female Subjects with hepatic insufficiency conforming to Child-Pugh classification C

Healthy Control subjects in good health

Inclusion Criteria - All subjects:

• Male and females ≥18 years old
• Women must be of non-childbearing potential
• Adequate hematologic and renal function
• BMI 18-35 kg/m2

Inclusion Criteria - Liver Impaired subjects:

• Subjects must have stable liver impairment diagnosed with standard classification - Child Pugh

Exclusion Criteria - All subjects:

• Inability to swallow or absorb oral medication
• Uncontrolled medical disorder or infection
• Use of CYP3A4 inhibitors/inducers or drugs with risk of Torsades de Pointes
• Uncontrolled or Significant cardiovascular disease
• Any significant bleeding disorder
• Female subjects of childbearing potential
• Male subjects unwilling to use an effective method of contraception throughout the conduct of the study and for 2 months thereafter