Meta-Analysis on Damage Control Surgery in Patients With Non-Traumatic Abdominal Emergencies
Damage-Control Surgery in Patients With Non-traumatic Abdominal Emergencies: A Systematic Review and Meta-Analysis
研究概览
地位
详细说明
After the successful implementation in trauma patients, damage control surgery (DCS) is being increasingly used in patients with non-traumatic abdominal emergencies, too. However, non-trauma DCS is an ongoing matter of debate as the open abdomen treatment typically performed in DCS is a non-anatomical situation and associated with potentially severe side effects. To date, DCS in patients with non-traumatic abdominal emergencies has not yet been comprehensively assessed in meta-analysis.
A systematic literature search will be conducted using the National Library of Medicine's Medline database (PubMed). The search strategy will be based on the PICOS process. Original research articles in English language addressing (1) mortality in patients undergoing non-trauma DCS vs. non-trauma conventional surgery or (2) the observed vs. expected mortality in non-trauma DCS will be included.
Two meta-analyses will be performed, comparing (1) mortality in patients undergoing non-trauma DCS vs. non-trauma conventional surgery and (2) the observed vs. expected mortality rate in patients undergoing non-trauma DCS based on outcome prediction scores. Meta-analysis will be performed using a random-effects model. The estimated effect size for mortality will be reported as risk difference with 95% confidence intervals. Sensitivity analysis will be performed by repeating the analysis in the subgroups of studies with the same study design and studies that applied the same outcome prediction score.
研究类型
注册 (实际的)
联系人和位置
学习地点
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Bern、瑞士、3010
- Inselspital, Bern University Hospial
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
取样方法
研究人群
描述
Inclusion Criteria:
- Articles on damage control surgery in patients with non-traumatic abdominal emergencies
- Reported in-hospital or 30-day mortality in patients undergoing non-trauma damage control surgery vs non-trauma conventional surgery or
- Reported observed in-hospital or 30-day mortality vs expected mortality in patients undergoing non-trauma damage control surgery
- Articles published from 2000 to 2020
- Articles including patients older than 18 years
- Original research articles
- Articles in English language
Exclusion Criteria:
- Articles describing trauma patients exclusively
- Articles describing pediatric patients (age below or equal to 18 years)
学习计划
研究是如何设计的?
设计细节
队列和干预
团体/队列 |
干预/治疗 |
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Non-trauma damge control surgery
Patients with non-traumatic abdominal emergencies undergoing damage control surgery.
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Surgery for non-traumatic abdominal emergencies using the damage control approach
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Non-trauma conventional surgery
Patients with non-traumatic abdominal emergencies undergoing conventional surgery with primary abdominal closure.
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Conventional surgery for non-traumatic abdominal emergencies
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
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Mortality
大体时间:From hospital admission to discharge, expected to be up to 4 weeks
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Death after surgery for non-traumatic abdominal emergencies
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From hospital admission to discharge, expected to be up to 4 weeks
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合作者和调查者
出版物和有用的链接
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
此信息直接从 clinicaltrials.gov 网站检索,没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求,请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改,我们的网站上也会自动更新.
Damage control surgery的临床试验
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Devicare S.L.Clever Instruments S.L.; Fundacio Puigvert未知
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Indiana UniversityEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)招聘中
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St. Joseph's Healthcare HamiltonHamilton Academic Health Sciences Organization完全的
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Gonzalez-Heydrich, Joseph, M.D.Boston Children's Hospital; Harvard University完全的