Benefit of CoQ-10 in Patients on Statins (CoQ-10)

Inclusion Criteria:

1. Adult men and women 21 years and older taking statin medications for hyperlipidemia under the current National Cholesterol Education Program guidelines (NCEP III) and complaining of myopathic symptoms.

Exclusion Criteria:

1. diagnosis of cancer;
2. acute illness of any sort;
3. hemoglobin less than 12,
4. creatinine greater than 1.5 mg/dl;
5. liver dysfunction as evidenced by elevations in transaminases 3-fold higher than upper limit of normal;
6. use of certain medications or nutritional supplements within the past month;
7. untreated hypertension (diastolic BP> 100 mm HG);
8. diagnosis of diabetes mellitus (fasting blood glucose > 126 mg/dl);
9. untreated hypothyroidism;
10. overt congestive heart failure (by physical exam);
11. active inflammatory diseases such as rheumatoid arthritis, lupus, etc.,
12. bleeding disorders;
13. history of adverse reactions besides myopathy associated with the use of statins;
14. any previous adverse reaction to coQ10 or to multivitamin supplements containing coQ10;
15. plasma CPK levels > 3 times the upper normal limit; OR
16. congenital myopathies and/or neuromuscular degenerative diseases.