Study of Specific Viral Immune Responses Induced by SARS-CoV-2 (COVID-19) (COV-CREM)

Inclusion Criteria:

• COVID-19 PCR positive,
• Hospitalized patients with illness of any duration, and/or SpO2 ≤ 92% on room air.
• Cohorte C : patients with cancer (hematological malignancies and solid tumors).

Exclusion Criteria:

• Refusal to participate,
• Any immunosuppressive therapy (i.e. corticosteroids >10mg of hydrocortisone or equivalent dose) within 14 days before the planned start of study,
• Active or chronic hepatitis B or C and/or HIV positive (HIV 1/2 antibodies patients), or a known history of active Tuberculosis bacillus,

• Active autoimmune disease that required a systemic treatment, with the following exceptions:

  • Patients with a history of autoimmune-related hypothyroidism who are on thyroid replacement hormone are eligible for the study,
  • Patients with controlled Type 1 diabetes mellitus who are on an insulin regimen are eligible for the study,
• Prior allogeneic bone marrow transplantation or prior solid organ transplantation,
• Patients currently exposed to chemotherapy, anti-tumor immunotherapy as anti-PD-1, anti-PD-L1, or anti-CTLA4 agent or any immune therapy or biotherapy (except for patients in cohort C),
• Previous prescribing of biotherapy or treatment for the management of COVID-19 is not an exclusion criterion,
• Patient under guardianship, curatorship or under the protection of justice.