- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT03365102
Modulating Impulsivity in Suicidal Adolescents With Transcranial Direct Current Stimulation (tDCS) (tDCS)
5. januar 2022 oppdatert av: Richard Liu, Lifespan
Modulating Impulsivity in Suicidal Adolescents With tDCS: A Proof of Concept Study
As a first step toward investigating whether modulation of impulsivity and associated neural pathways may yield clinically meaningful changes in risk for adolescent suicidal behavior, the R21 is a proof-of concept study evaluating the potential for tDCS targeting brain regions associated with behavioral impulsivity (right inferior frontal gyrus [rIFG]) and cognitive impulsivity (left orbitofrontal cortex [lOFC]) to modulate these facets of impulsivity in a sample of adolescent suicide attempters.
Participants will be randomly assigned to receive anodal tDCS over the rIFG, anodal tDCS over the lOFC, or a sham stimulation condition, in a three-group design.
Task-based measures of behavioral and cognitive impulsivity will be administered before and after tDCS or sham stimulation.
Additionally, electroencephalography (EEG) and event-related potential (ERP) data will be collected during the impulsivity tasks, and resting-state EEG data will be collected pre- and post-tDCS administration to confirm engagement of the targeted brain regions and to delineating the neural pathways underlying the effects of tDCS on impulsivity.
Studieoversikt
Status
Fullført
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
Suicide is one of the leading causes of death in adolescence.
To improve the ability to predict and prevent suicidal behavior, there is a pressing need for research in this area to advance beyond identifying risk factors toward a greater focus on the mechanisms of risk for this behavior.
In particular, elucidating the neural pathways underlying risk for suicidal behavior is important insofar as such work may yield specific and modifiable targets for clinical intervention.
The adoption of new experimental paradigms providing experimental control over potentially modifiable risk factors has been recommended as a means of meaningfully advancing the field in this regard.
Although yet to be applied to the study of suicidality, transcranial direct current stimulation (tDCS), in conjunction with measures of electroencephalography (EEG) and event-related potentials (ERPs), may hold promise as an experimental paradigm in the study of potentially modifiable risk factors, and underlying neural mechanisms, for suicidality.
One such risk factor of particular relevance to suicide in adolescence is state-sensitive aspects of impulsivity.
Impulsivity has been consistently linked with suicidality, with this association appearing to be stronger in adolescence than adulthood.
As a first step toward investigating whether modulation of impulsivity and associated neural pathways may yield clinically meaningful changes in risk for adolescent suicidal behavior, the R21 is a proof-of concept study evaluating the potential for tDCS targeting brain regions associated with behavioral impulsivity (right inferior frontal gyrus [rIFG]) and cognitive impulsivity (left orbitofrontal cortex [lOFC]) to modulate these facets of impulsivity in a sample of adolescent suicide attempters.
Participants will be randomly assigned to receive anodal tDCS over the rIFG, anodal tDCS over the lOFC, or a sham stimulation condition, in a three-group design.
Task-based measures of behavioral and cognitive impulsivity will be administered before and after tDCS or sham stimulation.
Additionally, EEG and ERP data will be collected during the impulsivity tasks, and resting-state EEG data will be collected pre- and post-tDCS administration to confirm engagement of the targeted brain regions and to delineating the neural pathways underlying the effects of tDCS on impulsivity.
Studietype
Intervensjonell
Registrering (Faktiske)
64
Fase
- Ikke aktuelt
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
-
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Rhode Island
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Riverside, Rhode Island, Forente stater, 02915
- Bradley Hospital
-
-
Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
13 år til 17 år (Barn)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Beskrivelse
Inclusion Criteria:
- have attempted suicide prior to admission
- speak and read English fluently
- do not display evidence of significant cognitive impairment, based on a standard psychiatric exam as well as school records on admission
- are not actively psychotic at time of intake.
Exclusion Criteria:
- a significant general medical condition
- history of seizure, head injury, brain surgery or tumor
- intracranial metallic implants or implanted electrical devices
- substance abuse or dependence in the past six months.
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Diagnostisk
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Dobbelt
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
---|---|
Eksperimentell: anodal tDCS over the rIFG,
|
tDCS at a constant current of 1.5 milliampere (mA) will be applied for one 20-minute session over the right inferior frontal gyrus .
Resting-state EEG for 10 minutes will be recorded immediately prior to and after tDCS.
After post-tDCS resting state EEG is acquired, EEG is recorded to extract Evoked Response Potentials in a single-blind procedure.
The participants and assessors will be blind to experimental condition.
|
Eksperimentell: anodal tDCS over the lOFC
|
tDCS at a constant current of 1.5 mA will be applied for one 20-minute session over the left orbitofrontal cortex .
Resting-state EEG for 10 minutes will be recorded immediately prior to and after tDCS.
After post-tDCS resting state EEG is acquired, EEG is recorded to extract Evoked Response Potentials in a single-blind procedure.
The participants and assessors will be blind to experimental condition.
|
Placebo komparator: sham tDCS stimulation
|
In the sham condition, the current will be ramped up to 1.5 mA for 30 seconds and then ramped back down to 0. As this commonly used sham procedure produces a brief tingling sensation, participants are kept unaware of their experimental condition.
Resting-state EEG for 10 minutes will be recorded immediately prior to and after the sham tDCS.
After post-sham stimulation resting state EEG is acquired, EEG is recorded to extract Evoked Response Potentials in a single-blind procedure.
The participants and assessors will be blind to experimental condition.
|
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
---|---|---|
Stopp signaloppgave (SST)
Tidsramme: Innen en time etter stimulering tilstand
|
Stop-Signal Task (SST) er en oppgave som krever inhibering av en prepotent motorisk respons.
SST krever at deltakerne reagerer på en målstimulus så raskt og nøyaktig som mulig ved å trykke på en knapp, men også å holde tilbake responsen når de hører et auditivt signal.
Dermed innebærer denne oppgaven en konkurranse mellom aktiverende og hemmende prosesser.
Den primære utfallsvariabelen er endring i stoppsignalreaksjonstiden (SSRT) for oppgaven administrert sekunder til minutter før og sekunder til minutter etter stimulering.
Det teoretiske minimum er null sekunder og det er ikke noe teoretisk maksimum.
Høyere SSRT-score reflekterer større impulsivitet.
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Innen en time etter stimulering tilstand
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Delay Discounting Task
Tidsramme: Within an hour post-stimulation condition
|
This task assessed discounting larger future rewards for smaller immediate ones.
The point where a person is equally likely to prefer immediate vs delayed reward (the indifference point) is determined for several and combinations of reward sizes and lengths of time.
Area under the curve (AUC) is calculated by summing the results of the following for each delay and indifference point pair: x2-x1[(y1 + y2)/2].
x1 and x2 are successive delays and y1 and y2 are indifference points for those delays.
AUC range=0-1.
Larger AUCs reflect less impulsivity.
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Within an hour post-stimulation condition
|
Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Etterforskere
- Hovedetterforsker: Richard Liu, PhD, Lifespan
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart (Faktiske)
1. april 2017
Primær fullføring (Faktiske)
31. desember 2019
Studiet fullført (Faktiske)
31. desember 2019
Datoer for studieregistrering
Først innsendt
2. august 2017
Først innsendt som oppfylte QC-kriteriene
5. desember 2017
Først lagt ut (Faktiske)
7. desember 2017
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
2. februar 2022
Siste oppdatering sendt inn som oppfylte QC-kriteriene
5. januar 2022
Sist bekreftet
1. januar 2022
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
Andre studie-ID-numre
- Liu 002017
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
JA
IPD-planbeskrivelse
Analysis files will be constructed from the stored electronic data and will be stripped of identifying information with the Safe Harbor method.
Specifically, youth and their parents will be identified with a family identifier and person identifier number that is randomly generated and not related to any element of their personal identifying information.
No names, addresses, telephone numbers, fax numbers, email addresses, social security numbers, medical records, etc. will be retained.
Dates will contain only year and a randomly generated day-of-the-year.
The investigators will only share it with external investigators when a data use agreement (DUA) is executed between Lifespan and the requester's institution.
The DUA will specify the requested data elements (each of which must be justified), the specific research question, the timeline for the project, and schedule for data destruction.
The data will be made available on April 1, 2021 by the PI
IPD-delingstidsramme
April 1, 2021
Tilgangskriterier for IPD-deling
The investigators will only share it with external investigators when a data use agreement (DUA) is executed between the Brown University and the requester's institution.
The DUA will specify the requested data elements (each of which must be justified), the specific research question, the timeline for the project, and schedule for data destruction.
IPD-deling Støtteinformasjonstype
- STUDY_PROTOCOL
- ICF
Legemiddel- og utstyrsinformasjon, studiedokumenter
Studerer et amerikansk FDA-regulert medikamentprodukt
Nei
Studerer et amerikansk FDA-regulert enhetsprodukt
Ja
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .
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