- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT01823263
Metabolic and Cognitive Parameters Following Partial Sleep Deprivation
27. november 2014 opdateret af: Uppsala University
Metabolic and Cognitive Effects of Sleep Deprivation
The purpose of this study is to determine whether partial sleep deprivation, as compared with normal sleep, influences certain metabolic and cognitive parameters, related to food intake, hunger and memory functions, when participants are shielded from external time cues.
Studieoversigt
Status
Ukendt
Betingelser
Detaljeret beskrivelse
It is predicted that partial sleep deprivation negatively affects the hormonal status, e.g.
upregulating ghrelin and other hunger-promoting hunger hormones, while showing impaired memory functions.
It is also predicted that participants will tend to increase their desired portion sizes after partial sleep deprivation, compared with after a normal night's sleep.
Undersøgelsestype
Interventionel
Tilmelding (Forventet)
20
Fase
- Ikke anvendelig
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiekontakt
- Navn: Jonathan Cedernaes, M.D., PhD
- E-mail: jonathan.cedernaes@neuro.uu.se
Undersøgelse Kontakt Backup
- Navn: Christian Benedict, PhD
- E-mail: christian.benedict@neuro.uu.se
Studiesteder
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Uppsala, Sverige, 75105
- Rekruttering
- Department of Neuroscience, Uppsala University
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Kontakt:
- Jonathan Cedernaes, M.D, PhD
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Kontakt:
- Christian Benedict, PhD
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Ledende efterforsker:
- Christian Benedict, PhD
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Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
20 år til 28 år (Voksen)
Tager imod sunde frivillige
Ingen
Køn, der er berettiget til at studere
Han
Beskrivelse
Inclusion Criteria:
- Male
- Age 20-28y
- Healthy (self-reported) and not on medication
- Non-smoking
- Normal sleep-wake rhythm (i.e. 7-8 h per night, self-reported and verified by sleep diaries)
- Normal dietary habits (regular meal pattern with daily breakfast)
Exclusion Criteria:
- Major illness
- Taking any serious medications
- Any sleep conditions (e.g. irregular bedtimes, sleep complaints)
- Any dietary issues with the food items provided
- A history of endocrine, neurological or psychiatric disorders
- Shift work in the previous 3 months
- Travel over several time zones within the previous two months
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Grundvidenskab
- Tildeling: Randomiseret
- Interventionel model: Crossover opgave
- Maskning: Enkelt
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
---|---|
Eksperimentel: Partial sleep deprivation
Partial sleep deprivation: participants will have a 4-h sleep opportunity before a 'Blood Sample' will be taken, and the 'Memory tasks', 'Working memory function task' and 'Portion size task' will be performed.
This will be followed by an 'Interference task', followed by repeated blood sampling and an 'Intake task'.
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Deltagerne får udleveret et computerprogram, der giver dem mulighed for at vælge de portioner af en række madvarer, som de helst vil indtage.
In the morning following partial sleep deprivation or normal sleep, a blood sample will be taken to assess the level of metabolism-linked and neurodegenerative-linked molecules, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as ghrelin
30-minute interference task
Participants will be allowed to learn a procedural memory task before going to bed.
Participants will be retested in the morning to assess their change in performance.
Other memory tests will also be given to assess the working memory performance in the morning following the intervention.
After a normal night of sleep or partial sleep deprivation, participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window.
Amount and selection will be recorded
Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD)
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Eksperimentel: Normal sleep
Normal sleep: participants will have an 8-h sleep opportunity before a 'Blood Sample' will be taken, and the 'Memory tasks', 'Working memory function task' and 'Portion size task' will be performed.
This will be followed by an 'Interference task', followed with repeated blood sampling and an 'Intake task'.
|
Deltagerne får udleveret et computerprogram, der giver dem mulighed for at vælge de portioner af en række madvarer, som de helst vil indtage.
In the morning following partial sleep deprivation or normal sleep, a blood sample will be taken to assess the level of metabolism-linked and neurodegenerative-linked molecules, as well as to assay blood serum and plasma for the presence of hormones involved in hunger such as ghrelin
30-minute interference task
Participants will be allowed to learn a procedural memory task before going to bed.
Participants will be retested in the morning to assess their change in performance.
Other memory tests will also be given to assess the working memory performance in the morning following the intervention.
After a normal night of sleep or partial sleep deprivation, participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window.
Amount and selection will be recorded
Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD)
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Memory tasks
Tidsramme: Change in memory performance between learning (at 2230 hours in NS and PSD condition) before going to sleep, and at 0800 and 0930 hours (following PSD or NS)
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Procedural memory performance after learning a procedural memory task close to going to bed, followed by either partial sleep deprivation (PSD) or normal sleep (NS), and comparing the performance the following morning at two time points.
Participants spatial memory performance in the morning at two time points, following PSD will also be compared with that following NS, after having learned such a memory task in the evening before going to bed.
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Change in memory performance between learning (at 2230 hours in NS and PSD condition) before going to sleep, and at 0800 and 0930 hours (following PSD or NS)
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Circulating hormone levels
Tidsramme: Change in circulating hormone levels and other metabolism-linked and neurodegeneration-associated molecules at 0730, 0830, 0910, 0925, 0940, 1010, 1040, 1105, and 1150 hours following the respective nighttime intervention and after the interference task
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Interference task given at 0900 hours
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Change in circulating hormone levels and other metabolism-linked and neurodegeneration-associated molecules at 0730, 0830, 0910, 0925, 0940, 1010, 1040, 1105, and 1150 hours following the respective nighttime intervention and after the interference task
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Intake task
Tidsramme: Change in intake at around 1200 hours, following the respective nighttime intervention (NS or PSD)
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Participants are presented with an ad libitum meal choice and can select the amount to ingest during a limited time window.
Amount and selection will be recorded.
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Change in intake at around 1200 hours, following the respective nighttime intervention (NS or PSD)
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Working memory function task
Tidsramme: Change in memory performance at 0800 hours and after the interference task again at 0930 hours (between and following PSD or NS)
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Participants will be evaluated on their working memory performance in the morning following either nighttime intervention (NS or PSD) and before and after an interference task
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Change in memory performance at 0800 hours and after the interference task again at 0930 hours (between and following PSD or NS)
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Portion Size Task
Tidsramme: Change in selected portion size from baseline (at 0800 hours following the nighttime intervention), to one hour later, i.e. after an interference task
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Participants will be evaluated on their tendency to choose larger or smaller portions of a variety of meal items on a computer screen.
This will be conducted both following partial sleep deprivation and normal sleep, and changes before and after a short interference task will be compared between these two conditions.
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Change in selected portion size from baseline (at 0800 hours following the nighttime intervention), to one hour later, i.e. after an interference task
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Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Christian Benedict, PhD, Department of Neuroscience, Uppsala University
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart
1. april 2013
Primær færdiggørelse (Forventet)
1. marts 2015
Studieafslutning (Forventet)
1. marts 2015
Datoer for studieregistrering
Først indsendt
21. februar 2013
Først indsendt, der opfyldte QC-kriterier
28. marts 2013
Først opslået (Skøn)
4. april 2013
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
2. december 2014
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
27. november 2014
Sidst verificeret
1. november 2014
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- SleepPartialJCCB2013
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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