- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT03000816
A Study of SBRT for OligoMetastatic ESCC
A Phase 2 Study of Stereotactic Body Radiotherapy (SBRT) for the Treatment of OligoMetastatic Esophageal Squamous Cell Carcinoma
Studieoversigt
Status
Betingelser
Intervention / Behandling
Undersøgelsestype
Tilmelding (Faktiske)
Fase
- Ikke anvendelig
Kontakter og lokationer
Studiesteder
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Shanghai
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Shanghai, Shanghai, Kina, 200032
- Fudan Universtiy Shanghai Cancer Center
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- Patients with metastatic esophageal squamous cell carcinoma who have received initial treatment for the primary site including surgery or chemoradiotherapy. Primary tumor site without progression at registration. The sites of allowed metastases are: peripheral lung, central lung, medistinal/cervical lymph node, liver, spinal/paraspinal, osseous, and abdominal-pelvic lymph node. All metastases not resected must be amenable to SBRT.
- 1-4 radiographically distinct metastases of any distribution in 2 or less allowed anatomical sites. The diameters of lesions should be less than or equal to 5cm.
- Initial treatment should be completed at least 3 months prior to study registration.
- All the metastases treated with SBRT should not be treated with surgery, radiation, radio frequency ablation or other regional therapeutic modalities prior to study registration. The other (s) lesions should have been surgically removed.
- Age ≥ 18. PS ECOG 0-2,wight loss<30% during the latest 6 months.
- Evaluation by a radiation oncologist that the patient could tolerate the treatment of SBRT.
- Patient must provide study specific informed consent prior to study entry.
- For females of child-bearing potential, negative serum/urine pregnancy test within 14 days prior to study registration.
Exclusion Criteria:
- Progression of primary tumor site at time of registration.
- Metastases with indistinct borders making targeting not feasible.
- Known brain metastases.
- Prior palliative radiotherapy to metastases.
Metastases located within 3 cm of the previously irradiated structures:
a).Spinal cord previously irradiated >80Gy(Biological equivalent dose with α/β=2), b).Brachial plexus previously irradiated to > 100Gy(Biological equivalent dose with α/β=2), c).Small intestine, large intestine, or stomach previously irradiated to > 90Gy (Biological equivalent dose with α/β=2), d).Whole lung previously irradiated with prior V20Gy > 30% (delivered in ≤ 3 Gy/fraction), e)Metastasis irradiated with SBRT.
- Pregnant or breast-feeding women or people during the birth-period who refused to take contraceptives.
- Drug addiction,Alcoholism or AIDS.
- Patients with severe organ dysfunction or Acute bacterial or fungal infection who are considered not suitable to enroll the study at the time of registration.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: N/A
- Interventionel model: Enkelt gruppeopgave
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
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Eksperimentel: Experimental Arm
Patients in this arm will receive a treatment of SBRT for their oligometastatic lesions.
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Patients with 1-4 metastases located in less than 2 organs/ lymphatic drainage regions that are 5 cm or less from each other and simultaneously treated with SBRT.
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
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Progression-free survival
Tidsramme: The survival time from the date each patient enrolled to the date of progression or date of death from any cause, whichever came first, assessed up to 5 years
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progression-free survival will be measured as time to either progression or death
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The survival time from the date each patient enrolled to the date of progression or date of death from any cause, whichever came first, assessed up to 5 years
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Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
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Local control
Tidsramme: the time from the date each patient enrolled to the date of local failure or the last follow-up, assessed up to 5 years.
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Local control will be measured as time to local recurrence
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the time from the date each patient enrolled to the date of local failure or the last follow-up, assessed up to 5 years.
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overall survival
Tidsramme: The survival time from the date each patient enrolled to the date of death or the last follow-up, assessed up to 5 years.
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Overall survival will be measured as time until death from any cause
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The survival time from the date each patient enrolled to the date of death or the last follow-up, assessed up to 5 years.
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Samarbejdspartnere og efterforskere
Sponsor
Efterforskere
- Studiestol: Kuaile Zhao, MD., Fudan Universtiy Shanghai Cancer Center
Publikationer og nyttige links
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Sygdomme i fordøjelsessystemet
- Neoplasmer efter histologisk type
- Neoplasmer
- Neoplasmer efter sted
- Neoplasmer, kirtel og epitel
- Gastrointestinale neoplasmer
- Neoplasmer i fordøjelsessystemet
- Gastrointestinale sygdomme
- Neoplasmer i hoved og hals
- Esophageale sygdomme
- Neoplasmer, pladecelle
- Esophageale neoplasmer
- Karcinom
- Karcinom, pladecelle
- Esophageal pladecellekarcinom
Andre undersøgelses-id-numre
- ESO-Shanghai10
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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Shandong UniversityUkendtEsophageal Squamous Intraepithelial NeoplasiaKina
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Association Pour La Recherche des Thérapeutiques...AfsluttetClear Cell Metastatic Renal Cell CarcinomaFrankrig
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The First Affiliated Hospital of Henan University...Ikke rekrutterer endnuEsophageal Carcinoma in Situ AJCC V7
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Peking University Cancer Hospital & InstituteUkendtEsophageal pladecellekarcinom | Mild dysplasi i spiserøret | Moderat dysplasi i spiserøret | Alvorlig dysplasi i spiserøret | Carcinoma in situ i spiserøretKina
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Incyte CorporationAktiv, ikke rekrutterendeLivmoderhalskræft | Nasopharyngealt karcinom | Avancerede solide tumorer | Mesotheliom | Småcellet lungekræft | Esophageal pladecellekarcinom | Merkel cellekarcinom | Sarcomatoid nyrecellekarcinom | Anal karcinom | Kutant planocellulært karcinom | MSI-H/dMMR-tumorer | PD-L1 amplificeret tumor (9p24.1) | Urothelial... og andre forholdFinland, Forenede Stater, Det Forenede Kongerige, Belgien, Sverige, Danmark, Norge
Kliniske forsøg med SBRT
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Duke UniversityGateway for Cancer ResearchAktiv, ikke rekrutterendeBrystkræftForenede Stater
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Sidney Kimmel Comprehensive Cancer Center at Johns...AfsluttetSarkom | Metastatisk sygdom | Bony SitesForenede Stater
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Soonchunhyang University HospitalSMG-SNU Boramae Medical CenterIkke rekrutterer endnuNeoplasmer | Sekundær malign neoplasma
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Mercy ResearchAfsluttetArteriovenøse misdannelser | Neurofibrom | Chordoma | Meningiom | Schwannoma | Spinale metastaser | Paragangliomer | Vertebrale metastaser | Godartede spinale tumorerForenede Stater
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Kantonsspital Winterthur KSWKrebsforschung Schweiz, Bern, SwitzerlandRekrutteringSmerte | Knoglemetastaser | StråleterapiSchweiz
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Fudan UniversityIkke rekrutterer endnuNasopharyngealt karcinom | Metastase | Stereotaktisk kropsstrålingsterapiKina
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Peking University Third HospitalAktiv, ikke rekrutterendeStereotaktisk strålebehandling med forskellige fraktioneringsmetoder for tidlig lungekræft (DSBRT-1)Lungekræft | Strålebehandling | Stereotaktisk kropsstrålebehandling | FraktioneringKina
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Medical College of WisconsinAfsluttetStage IV Blødt vævssarkom for voksne | Sarkom, blødt vævForenede Stater