A Multi-Center Randomised Controlled Study to Evaluate Laparoscopic Versus Open Surgery for Colorectal Cancer

Inclusion Criteria:

• Informed consent
• Pathologically confirmed adenocarcinoma
• Pre-surgery image staging as (CT/MRI):T2-3,N0-2,M0,(TNM stage，AJCC，version of 2003)
• Single tumor locating at cecum, ascending colon, descending colon, sigmoid colon, rectosigmoid junction, rectum(distance from anal verge more than 7cm)
• Tumor diameter less than 6cm
• Age 18-75 year
• ECOG 0-2
• Predicted survival longer than 6 months
• Normal liver, renal, bone marrow function: (GPT less than 2 ULN，total bilirubin less than 1.5mg/dl，Cr less than 1.5 ULN，WBC more than 4×109/L，PLT more than 100×109/L)
• No previous history of gastrointestinal surgery
• No previous history of chemotherapy or radiotherapy

Exclusion criteria

• Severe and uncontrolled medical disease including unstable angina pectoris, cardiac infarction and cerebral attack in 6 months
• Could not tolerant general anesthesia or surgery for other organ dis-function
• Allergy to chemotherapeutical agents in the protocol
• History of other malignant tumor within 5 years
• Severe mental disorder
• Continued systematic steroid therapy
• Woman during pregnancy or lactation
• Under study of other clinical trial
• No compliance of the protocol
• Discovery of distant metastasis during surgery
• Postsurgery stage of I or IV tumors