De gunstige effecten van dutjes op motorisch leren
Mechanismen die ten grondslag liggen aan de gunstige effecten van dutjes op motorisch leren
Background:
Memory consolidation is the process by which memories become stable, long-term representations in the brain. Consolidation of a motor skill is dependent upon sleep. Some research shows that daytime naps improve people s motor performance and memory retention. Researchers want to find out how daytime naps may contribute to learning and support consolidation of motor skill memories.
Objective:
To learn the role of memory replay during wakeful rest and sleep (naps) in retaining a newly learned skill.
Eligibility:
English-speaking adults ages 18 and older with chronic stroke, or healthy, right-handed, English-speaking adults ages 18-35 and 50-80
Design:
Participants will be screened with:
- medical history
- neurological history
- medicine review
- medical exam
- neurological exam.
Participants will have a magnetic resonance imaging (MRI) scan of the brain. For this, they will lie down in a scanner. The scanner makes loud noises, so they will wear earplugs. They will fill out an MRI screening form before each MRI.
Participants will also have magnetoencephalography (MEG). MEG maps brain activity. It does this by recording the magnetic fields produced by naturally occurring electrical currents in the brain. For MEG, participants will lie down in the MEG room. Their eye movements may be recorded by a video camera.
Participants will have behavior testing. They will practice typing random keys. Then they will repeatedly type a custom sequence that they see on a computer screen. Then they will take a 2-hour nap. Then they will type the same sequence again.
Participants will have no more than 4 visits at the NIH over 3 months. Visits will last 2-4 hours each.
Studie Overzicht
Toestand
Conditie
Interventie / Behandeling
Gedetailleerde beschrijving
Study Description:
We will investigate the within-individual contribution of wakeful and sleep neural replay to motor skill consolidation in three groups: (a) young healthy subjects, (b) older healthy subjects and (c) patients with chronic stroke.
Objectives:
The primary aim is to determine the relative contribution of neural replay during wakeful rest and sleep to consolidation of a newly learned skill in young and older healthy volunteers, and in chronic stroke patients with magnetoencephalography (MEG). The secondary aim is to evaluate differences in replay rates between these subject cohorts. We will also explore differences in replay rates, spatiotemporal dynamics of neural replay and sleep spindles to generate additional hypotheses and preliminary data for future studies.
Endpoints:
The primary endpoint measure is motor skill consolidation (i.e., offline change in correct sequence typing speed following a nap). The secondary endpoint measure is neural replay rate. Exploratory endpoints measures are spatial (i.e. - parcellated source space) and time-frequency maps of neural replay during wakeful rest and sleep, and changes in button-press finger movement kinematics during learning.
Studietype
Inschrijving (Geschat)
Contacten en locaties
Studiecontact
- Naam: Leonardo G Cohen, M.D.
- Telefoonnummer: (301) 496-9782
- E-mail: cohenl1@mail.nih.gov
Studie Contact Back-up
- Naam: Catherine L Blumhorst, C.R.N.P.
- Telefoonnummer: (301) 451-1335
- E-mail: cathy.blumhorst@nih.gov
Studie Locaties
-
-
Maryland
-
Bethesda, Maryland, Verenigde Staten, 20892
- Werving
- National Institutes of Health Clinical Center
-
Contact:
- For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
- Telefoonnummer: TTY8664111010 800-411-1222
- E-mail: prpl@cc.nih.gov
-
-
Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
Accepteert gezonde vrijwilligers
Geslachten die in aanmerking komen voor studie
Bemonsteringsmethode
Studie Bevolking
Right-handed adults between the ages of 18 and 80.
Beschrijving
- HEALTHY VOLUNTEERS:
INCLUSION CRITERIA:
- Age 18-35 (Arm 1) or 50-80 (Arms 2).
- English speaking.
- Clear right-hand dominance (>74 on Edinburgh Handedness Inventory).
- Normal neurological examination as determined by the screening clinician.
EXCLUSION CRITERIA:
- HCPS affiliated NIH staff (i.e. - staff from our section).
- Current pregnancy.
- Contraindications for MRI or MEG.
- Use of sleep medications within 24 hours of Experimental Session participation.
- Severe or progressive neurological, psychological or medical condition as determined by the screening clinician.
STROKE PATIENTS:
INCLUSION CRITERIA:
- Age 18 or older
- Willing and able to provide consent
- Experienced a stroke 6 months ago or more that affected at least one of the upper extremities at time of stroke diagnosis
- Ability to perform the study task as assessed during physical examination
- English-speaking
EXCLUSION CRITERIA:
- HCPS-affiliated NIH staff (i.e. - staff from our section).
- Current pregnancy
- History of large stroke lesions in brainstem or cerebellum as determined by screening clinician
- Severe or progressive neurological disorder other than stroke (e.g., Parkinson s disease or multiple sclerosis) as determined by the screening clinician
- Uncontrolled heart, lung, kidney, gastrointestinal, metabolic, psychiatric, sleep, or endocrine disorders as determined by the screening clinician
- Contraindications for MRI or MEG.
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
- Observatiemodellen: COHORT
- Tijdsperspectieven: PROSPECTIVE
Cohorten en interventies
Groep / Cohort |
Interventie / Behandeling |
|---|---|
|
Arm 1
46 healthy young (18-35) volunteers |
|
|
Arm 2
46 healthy older (50-80) volunteers |
|
|
Arm 3
46 chronic (>6 months post-stroke) stroke patients |
MRI system - GE Discovery MR750 3T MEG system The CTF MEG 275 Magnetoencephalography (MEG) scanner system |
Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
The primary endpoint measure is the degree to which motor skill consolidation (i.e., offline change in correct sequence typing speed) is predicted by replay rates during wakeful rest and sleep, and spindle rates during sleep (i.e. multiple r...
Tijdsspanne: 4 years
|
The primary endpoint measure is the degree to which motor skill consolidation (i.e., offline change in correct sequence typing speed) is predicted by replay rates during wakeful rest and sleep, and spindle rates during sleep (i.e. multiple regression model with 3 predictors). |
4 years
|
Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
Exploratory endpoints measures are spatial (i.e. - parcellated source space) and time-frequency maps of neural replay during wakeful rest and sleep.
Tijdsspanne: 4 years
|
Exploratory endpoints measures are spatial (i.e. - parcellated source space) and time-frequency maps of neural replay during wakeful rest and sleep. |
4 years
|
Medewerkers en onderzoekers
Onderzoekers
- Hoofdonderzoeker: Leonardo G Cohen, M.D., National Institute of Neurological Disorders and Stroke (NINDS)
Publicaties en nuttige links
Nuttige links
Studie record data
Bestudeer belangrijke data
Studie start (Werkelijk)
Primaire voltooiing (Geschat)
Studie voltooiing (Geschat)
Studieregistratiedata
Eerst ingediend
Eerst ingediend dat voldeed aan de QC-criteria
Eerst geplaatst (Werkelijk)
Updates van studierecords
Laatste update geplaatst (Werkelijk)
Laatste update ingediend die voldeed aan QC-criteria
Laatst geverifieerd
Meer informatie
Termen gerelateerd aan deze studie
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- 200060
- 20-N-0060
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
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