- ICH GCP
- US Clinical Trials Registry
- Klinisk utprøving NCT01660750
A Safety Study of Carfilzomib, Cyclophosphamide & Dexamethasone Prior to ASCT in Patients With Newly Diagnosed Myeloma (11-MM-01)
16. oktober 2017 oppdatert av: Criterium, Inc.
A Multi-Center Phase Ib, Open-Label, Dose-Finding Pilot Study to Evaluate the Combination of Carfilzomib and Cyclophosphamide With Dexamethasone Prior to ASCT in Patients With Transplant Eligible Newly Diagnosed Myeloma
This is a dose finding pilot study to evaluate the safety and determine the maximum tolerated dose of the combination of carfilzomib and cyclophosphamide with dexamethasone (Car-Cy-Dex) prior to autologous stem cell transplant (ASCT) in patients with newly diagnosed transplant eligible multiple myeloma.
Studieoversikt
Status
Fullført
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
This is a dose finding pilot study to evaluate the safety and determine the maximum tolerated dose of the combination of carfilzomib and cyclophosphamide with dexamethasone (Car-Cy-Dex) prior to autologous stem cell transplant (ASCT) in patients with newly diagnosed transplant eligible multiple myeloma.
The study will also explore the efficacy of Car-Cy-Dex including overall response after induction therapy, overall response at 3 and 6 months post ASCT, and time to progression, progression free survival, and time to next therapy if it occurs within 6 months post ASCT.
Studietype
Intervensjonell
Registrering (Faktiske)
29
Fase
- Fase 1
Kontakter og plasseringer
Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.
Studiesteder
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California
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Los Angeles, California, Forente stater, 90048
- Samuel Oschin Comprehensive Cancer Center at Cedars-Sinai Medical Center
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Palm Springs, California, Forente stater, 92262
- Comprehensive Cancer Center at Desert Regional Medical Center
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Massachusetts
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Worcester, Massachusetts, Forente stater, 01655
- University of Massachusettes Memorial
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North Carolina
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Durham, North Carolina, Forente stater, 27710
- Duke University Medical Center
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Washington
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Seattle, Washington, Forente stater, 98109
- Fred Hutchinson Cancer Research Center
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Deltakelseskriterier
Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
18 år og eldre (Voksen, Eldre voksen)
Tar imot friske frivillige
Nei
Kjønn som er kvalifisert for studier
Alle
Beskrivelse
Inclusion Criteria:
- Cytopathologically or histologically confirmed diagnosis of MM
- Measurable disease, as indicated by one or more of the following:
- Serum M-protein ≥ 1.0 g/dL
- Urine Bence Jones protein ≥ 200 mg/24 hr
- Elevated Free Light Chain as per the International Myeloma Working Group (IMWG) criteria
- Males and females ≥ 18 years of age
- Life expectancy of more than 5 months
- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-2
- Adequate hepatic function, with bilirubin < 2 times the upper limit of normal (ULN), and aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3.5 times ULN
- Serum Creatinine Clearance(CrCl) ≥ 30 mL/min, either measured or calculated using a standard formula (e.g. Cockcroft and Gault)
- Additional Laboratory Requirements
- Absolute neutrophil count (ANC) ≥1.0 x 109/L
- Hemoglobin ≥8 g/dL [transfusion permitted]
- Platelet count ≥50.0 x 109/L
- Screening ANC should be independent of granulocyte-and granulocyte/macrophage colony stimulating factor (G-CSF and GM-CSF) support for at least 1 week and of pegylated G-CSF for at least 2 weeks
- Patients may receive RBC or platelet transfusions, if clinically indicated, in accordance with institutional guidelines
- Written informed consent in accordance with federal, local, and institutional guidelines
- Patients must agree to practice contraception
- Male patients must agree not to donate semen or sperm.
Exclusion Criteria:
- Patients with non-secretory or hyposecretory MM
- Prior treatment for MM (prior radiation therapy or dexamethasone up to 160 mg for spinal cord compression is allowed. Other limited field radiation involving ≤ 1/3 of the pelvic area is also allowed)
- Plasma cell leukemia
- Pregnant or lactating females
- Major surgery within 21 days prior to first dose
- Congestive heart failure (CHF) (New York Heart Association class III to IV), symptomatic ischemia, conduction abnormalities uncontrolled by conventional intervention or myocardial infarction in the previous six months
- Acute active infection requiring systemic antibiotics, antivirals, or antifungals within 14 days prior to first dose
- Patients receiving active treatment or intervention for any other malignancy or patients who, at the Investigator's discretion, may require active treatment or intervention for any other malignancy within 8 months of starting study treatment.
- Serious psychiatric or medical conditions that could interfere with treatment
- Significant neuropathy (Grade 3, Grade 4, or Grade 2 with pain) at the time of the first dose and/or within 14 days before study treatment
- Contraindication to any of the required concomitant drugs, including antiviral (e.g. Valacyclovir) and proton-pump inhibitor (e.g. lansoprazole). Corticosteroid therapy in a dose equivalent to dexamethasone ≥ 1.5 mg/day or prednisone ≥ 10 mg/day. (Steroid use is allowed if necessary to treat spinal cord compression and/or hypocalcaemia.)
- Patients in whom the required program of oral and IV fluid hydration is contraindicated, e.g. due to pre-existing pulmonary, cardiac, or renal impairment
- Patients with primary systemic amyloidosis.
Studieplan
Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: N/A
- Intervensjonsmodell: Enkeltgruppeoppdrag
- Masking: Ingen (Open Label)
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
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Eksperimentell: Carfilzomib, Cyclophosphamide, Dexamethasone
All eligible subjects will receive Carfilzomib, Cyclophosphamide, and Dexamethasone.
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IV over 30 minutter på dag 1,2,8,9,15 og 16 hver 28. dag
Andre navn:
40 mg ukentlig PO eller IV på dag 1, 8, 15 og 22, hver 28. dag.
Andre navn:
PO on days 1, 8, and 15 every 28 days
Andre navn:
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Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
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Adverse Events as a measure of safety and tolerability
Tidsramme: Throughout treatment, estimated to be 4-6 months per patients
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Review of adverse events for safety and to determine the maximum tolerated dose of the combination treatment.
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Throughout treatment, estimated to be 4-6 months per patients
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Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
---|---|---|
Overall Response after induction therapy
Tidsramme: Every 28 days during induction therapy, estimated to be 4-6 months
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Overall response (PR, VGPR, CR, sCR)
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Every 28 days during induction therapy, estimated to be 4-6 months
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Overall Response post ASCT
Tidsramme: 3 and 6 months post ASCT
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Overall Response (PR, VGPR, CR, sCR) at 3 and 6 months post ASCT.
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3 and 6 months post ASCT
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Time to Progression
Tidsramme: Througout treatment and 3 and 6 months post ASCT
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Time to progression will be noted if it occurs within 6 months post ASCT.
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Througout treatment and 3 and 6 months post ASCT
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Progression Free Survival
Tidsramme: up to 6 months post ASCT
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up to 6 months post ASCT
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Time to Next Therapy
Tidsramme: up to 6 months post ASCT
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Time to Next Therapy if occurs within 6 months post ASCT
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up to 6 months post ASCT
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Samarbeidspartnere og etterforskere
Det er her du vil finne personer og organisasjoner som er involvert i denne studien.
Sponsor
Samarbeidspartnere
Etterforskere
- Hovedetterforsker: Brian GM Durie, MD, AMyC
- Hovedetterforsker: Jatin Shah, MD, AMyC
Studierekorddatoer
Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.
Studer hoveddatoer
Studiestart
1. januar 2013
Primær fullføring (Faktiske)
1. august 2015
Studiet fullført (Faktiske)
1. desember 2015
Datoer for studieregistrering
Først innsendt
7. august 2012
Først innsendt som oppfylte QC-kriteriene
7. august 2012
Først lagt ut (Anslag)
9. august 2012
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
18. oktober 2017
Siste oppdatering sendt inn som oppfylte QC-kriteriene
16. oktober 2017
Sist bekreftet
1. oktober 2017
Mer informasjon
Begreper knyttet til denne studien
Ytterligere relevante MeSH-vilkår
- Kardiovaskulære sykdommer
- Vaskulære sykdommer
- Sykdommer i immunsystemet
- Neoplasmer etter histologisk type
- Neoplasmer
- Lymfoproliferative lidelser
- Immunproliferative lidelser
- Hematologiske sykdommer
- Hemoragiske lidelser
- Hemostatiske lidelser
- Paraproteinemier
- Blodproteinforstyrrelser
- Multippelt myelom
- Neoplasmer, plasmacelle
- Fysiologiske effekter av legemidler
- Molekylære mekanismer for farmakologisk virkning
- Autonome agenter
- Agenter fra det perifere nervesystemet
- Anti-inflammatoriske midler
- Antirevmatiske midler
- Antineoplastiske midler
- Immunsuppressive midler
- Immunologiske faktorer
- Antiemetika
- Gastrointestinale midler
- Glukokortikoider
- Hormoner
- Hormoner, hormonsubstitutter og hormonantagonister
- Antineoplastiske midler, hormonelle
- Antineoplastiske midler, Alkylering
- Alkyleringsmidler
- Myeloablative agonister
- Deksametason
- Cyklofosfamid
Andre studie-ID-numre
- AMyC 11-MM-01
- CAR-IST-520 (Annen identifikator: Onyx Pharmaceuticals)
Plan for individuelle deltakerdata (IPD)
Planlegger du å dele individuelle deltakerdata (IPD)?
UBESLUTTE
Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .
Kliniske studier på Multippelt myelom
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National Cancer Institute (NCI)Aktiv, ikke rekrutterendeMyelom-multippel | Myelom, plasmacelleForente stater
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National Cancer Institute (NCI)FullførtMyelom-multippel | Myelom, plasmacelleForente stater
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National Cancer Institute (NCI)FullførtMyelom-multippel | Myelom, plasmacelleForente stater
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National Cancer Institute (NCI)AvsluttetMyelom, multippel | Myelom-multippelForente stater
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Tel-Aviv Sourasky Medical CenterFullførtPlasmacellemyelom | Myelom-multippel | Myelom multippel | Myelom, plasmacelleIsrael
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National Cancer Institute (NCI)Georgetown University; Hackensack Meridian HealthAvsluttetMyelom-multippel | Myelom, plasmacelle | MyelomatoseForente stater
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University of ChicagoNational Cancer Institute (NCI)Aktiv, ikke rekrutterendeStage I Myelom | Stadium II multippelt myelom | Stadium III multippelt myelomForente stater, Canada
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Sidney Kimmel Cancer Center at Thomas Jefferson...FullførtStage I Myelom | Stadium II multippelt myelom | Stadium III multippelt myelomForente stater
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University of Southern CaliforniaNational Cancer Institute (NCI); Celgene CorporationAvsluttetStage I Myelom | Stadium II multippelt myelom | Stadium III multippelt myelomForente stater
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Case Comprehensive Cancer CenterNational Cancer Institute (NCI)TilbaketrukketStage I Myelom | Stadium II multippelt myelom | Stadium III multippelt myelom
Kliniske studier på Carfilzomib
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Ajai ChariAmgenFullførtRefraktært myelomatose | Tilbakefall myelomatoseForente stater
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M.D. Anderson Cancer CenterOnyx Therapeutics, Inc.Avsluttet
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University of ArkansasOnyx Therapeutics, Inc.Ikke lenger tilgjengelig
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Thomas LundRekruttering
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Washington University School of MedicineFullført
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NovartisAmgenAvsluttet
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AmgenMultiple Myeloma Research FoundationGodkjent for markedsføring
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AmgenFullførtSluttstadium nyresykdom | Tilbakefallende myelomatoseForente stater, Australia, Canada
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AmgenFullførtNyreinsuffisiens | Multippelt myelomForente stater
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SCRI Development Innovations, LLCAmgenFullførtNevroendokrin kreftForente stater