- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT03152344
Evaluation of a Simple Clinical Test to Detect the Risk of Falling in Patients With BPCO and Research for Predictive Factors of Fall Risk. (Equil-BPCO)
Evaluation of a Simple Clinical Test to Detect the Risk of Falling in Patients With Chronic Obstructive Pulmonary Disease and Research for Predictive Factors of Fall Risk.
The risk of falling in increased in patients with Chronic Obstructive Pulmonary Disease. To date, a screening test (the Berg Balance scale, BBS) is used to evaluate this risk but it spends 20 to 30 minutes to complete.
The aim of our study is to evaluate the sensitivity of a more straightforward test (Timed Up and Go, TUG)) to assess the fall risk. The TUG is routinely used in elderly to screen for frailty.
Studieoversigt
Detaljeret beskrivelse
We will recruit COPD patients in stable condition (free of exacerbation of the disease for a month), 40 without chronic respiratory failure and 40 with home oxygen therapy.
The patients will be proposed to perform the following tests and to fill in questionnaires:
- Questionnaires: Elderly Falls Screening Test to quantify the falls in the last year, Hospital Anxiety and Depression Scale, Activities-specific Balance Confidence scale.
Tests:
- Berg Balance Scale measuring balance in 14 different functional tasks (abnormal cut-off value <56)
- Timed Up and Go evaluating the time to rise from a chair, walk 3 meters, turn around, walk back to the chair and sit down (abnormal cut-off value >12 seconds).
- 6 minute walk test evaluating endurance to submaximal exercise.
- Isokinetic maximal force of the quadriceps at 60°/s
- Balance control: posturography consisting in measuring variations when standing on a force platform.
- Body composition assessment through Dual Xray Absorptiometry (DXA), to measure body muscle mass and more specifically appendicular muscle mass index as a criteria of sarcopenia, and bone mineral density.
- Blood analysis: a blood sample will be withdrawn to measure calcium, phosphorus, vitamin D, albumin transthyretin, cell count, C reactive protein.
Analysis of the results:
We will calculate the sensitivity of the TUG test (abnormal test) to detect fall risk as assessed by an abnormal BBS score.
Moreover, in fallers, we will search for predictive factors. More specifically, we will look for the role of a decreased quadriceps force, a reduced muscle mass, a poor tolerance of exercise, the presence of hypoxia (severity of the disease).
Perspectives:
When validated as a screening test for the risk of falling in COPD patients, the TUG test could be used routinely by physiotherapists as a more simple and faster test and will enable to prevent falls through initiation of a balance control training program.
Undersøgelsestype
Tilmelding (Faktiske)
Kontakter og lokationer
Studiesteder
-
-
Auvergne
-
Clermont-Ferrand, Auvergne, Frankrig, 63003
- CHU de Clermont-Ferrand
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
- COPD confirmed by pulmonary function tests
- Long term oxygen therapy since at least 3 months in the LOT+ subgroup
Exclusion Criteria:
- Exacerbation of COPD necessitating an hospitalization or an oral corticosteroid treatment, in the last 4 weeks
- Pulmonary rehabilitation in the last 3 months
- Any neurological disease affecting balance control.
- Inability to perform a walk test
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
---|---|
COPD patients without chronic respiratory failure
We will recruit COPD patients in stable condition (free of exacerbation of the disease for a month), 40 without chronic respiratory failure and 40 with home oxygen therapy. The patients will be proposed to perform the following tests and to fill in questionnaires |
It's a functional test evaluating the time to rise from a chair, walk 3 meters, turn around, walk back to the chair and sit down (abnormal cut-off value >12 seconds).
|
COPD patients with home oxygen therapy
We will recruit COPD patients in stable condition (free of exacerbation of the disease for a month), 40 without chronic respiratory failure and 40 with home oxygen therapy. The patients will be proposed to perform the following tests and to fill in questionnaires |
It's a functional test evaluating the time to rise from a chair, walk 3 meters, turn around, walk back to the chair and sit down (abnormal cut-off value >12 seconds).
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Comparison of the Timed Up and Go test and the Berg Balance scale
Tidsramme: at day 1
|
Comparison of the consistency of abnormal value of the Timed Up and Go test and the Berg Balance scale
|
at day 1
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
---|---|---|
Sensitivity of the TUG test and the BBS
Tidsramme: at day 1
|
to detect fall as assessed by the Elderly Falls Screening Test.
|
at day 1
|
Difference in BBS score
Tidsramme: at day 1
|
between COPD patients without and with chronic respiratory failure (LOT+/- subgroups).
|
at day 1
|
Identify predictive factors of fall risk
Tidsramme: at day 1
|
walk distance, quadriceps force, muscle mass, balance control.
|
at day 1
|
Samarbejdspartnere og efterforskere
Samarbejdspartnere
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Faktiske)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Andre undersøgelses-id-numre
- CHU-332
- 2016-A01188-43 (Anden identifikator: 2016-A01188-43)
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Studerer et amerikansk FDA-reguleret enhedsprodukt
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med COPD Diagnosed
-
Baylor Research InstituteIkke rekrutterer endnu
-
Vastra Gotaland RegionRekruttering
-
Baystate Medical CenterNational Heart, Lung, and Blood Institute (NHLBI); University of Illinois... og andre samarbejdspartnereTrukket tilbage
-
Centre Hospitalier Intercommunal CreteilUniversity Hospital, Bordeaux; University Hospital, Caen; Centre Hospitalier... og andre samarbejdspartnereUkendt
-
Assiut UniversityIkke rekrutterer endnu
-
University of CalgaryAktiv, ikke rekrutterende
-
Marmara UniversityAfsluttet
-
University Hospital, BrestAfsluttet
-
VA Boston Healthcare SystemUkendt
-
Assiut UniversityIkke rekrutterer endnu
Kliniske forsøg med Timed Up and Go
-
Dalarna UniversityUppsala University; The Swedish Research CouncilRekrutteringDemens | Mild kognitiv svækkelse | Demens, blandet | Demens af Alzheimer-typen | Subjektiv kognitiv svækkelse | Senil demensSverige
-
Acibadem UniversityMarmara UniversityAfsluttetFedme | Knæ arthritis | Artroplastiske komplikationer | Balance; ForvrængetKalkun
-
Afyonkarahisar Health Sciences UniversityRekruttering
-
University of Rhode IslandStuart Sinoff, MD; Peter J Snyder, MD; BayCare Health SystemRekrutteringKognitiv forandring | Alzheimers sygdom | Aldring | Mild kognitiv svækkelse | Mild demensForenede Stater
-
Istanbul Medeniyet UniversityUkendtOsteoporose, postmenopausal | Balance; ForvrængetKalkun
-
Hacettepe UniversityAfsluttetParkinsons sygdom | BevægelsesforstyrrelserKalkun
-
Istanbul Medeniyet UniversityUkendtSarkopeni | Osteoporose, postmenopausal | Balance; ForvrængetKalkun
-
Istanbul Medeniyet UniversityUkendtSlag | Balance; ForvrængetKalkun
-
Clalit Health ServicesUkendtÆldre | Falder | Postural balanceIsrael
-
Gazi UniversityAfsluttetMultipel scleroseKalkun