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Somatiske symptomer ved autismespektrumforstyrrelse: dataintegration

13. august 2026 opdateret af: National Taiwan University Hospital
Autistiske patienter har større chancer for komorbide somatiske symptomer. Derfor fører det til flere sundhedsrelaterede bekymringer, såsom autoimmune sygdomme, mave-tarmsygdomme, hjerte-kar-sygdomme, autonome lidelser. I gennemsnit er autistiske patienters levetid 16 år kortere end ikke-autistiske patienter. Desuden er autistiske patienter ikke i stand til at formidle eller kommunikere deres somatiske symptomer på en klar og omfattende måde. Dette fører til ude af stand til at modtage ordentlig sundhedspleje i tide.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Undersøgelsestype

Observationel

Tilmelding (Anslået)

600

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Taiwan
      • Taipei, Taiwan
        • National Taiwan University Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Barn
  • Voksen
  • Ældre voksen

Tager imod sunde frivillige

Ja

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

som tidligere nævnt er det et retrospektivt studie med eksisterende data. Derfor er de 1423 deltagere allerede tidligere samlet. Vi opdeler disse eksisterende data i tre grupper som nævnt i berettigelseskriterierne

Beskrivelse

Inklusionskriterier:

  • ASD-gruppe: diagnosticeret med DSM-5 autismespektrumforstyrrelse
  • klinisk gruppe: angst, depression, somatisk lidelse, som er ikke-psykotiske og ikke-organiske
  • kontrolgruppe: sund kontrol uden psykiatrisk lidelse eller kroniske somatiske symptomer
  • alder mellem 15 og 70

Ekskluderingskriterier:

  • psykiatriske lidelser såsom skezofreni, stemningslidelse.
  • alvorlig fysisk lidelse, som kan være potentielt dødelig
  • som ikke kan læse eller forstå undersøgelsen og spørgeskemaet

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Intervention / Behandling
ASD
Diagnosticeret med DSM-5 autismespektrumforstyrrelse
Andet: Ingen indgriben involveret
Ingen indgriben involveret
Klinisk
Patienter med angst, depression, somatiske symptomer, som er ikke-psykotiske og ikke-organiske
Andet: Ingen indgriben involveret
Ingen indgriben involveret
Styring
Sund kontrol uden psykiatrisk lidelse eller kroniske somatiske symptomer
Andet: Ingen indgriben involveret
Ingen indgriben involveret

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Patient health questionnaire-15, PHQ-15
Tidsramme: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
range from 0 to 2 for each item, total score range from 0 to 30. Higher the score, worse the level of somatization
Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
Health assessment questionnaire, HAQ
Tidsramme: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
range from 0 to 3 for each item. Higher the score, worse the disability
Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
Beck depression inventory, BDI
Tidsramme: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
range from 0 to 3 for each item. Higher the score, worse the depression
Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
Beck anxiety inventory
Tidsramme: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
range from 0 to 3 for each item. Total score 0 to 63. Higher the score, worse the anxiety
Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
Tridimensional Personality Questionnaire (TPQ)
Tidsramme: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)

a 100-item, true/false psychological test, measures three neurotransmitter-linked personality dimensions:

  1. novelty seeking. High scores indicate individuals who are adventurous, easily bored, impulsive, and quick to react to new stimuli. Low Scores indicate individuals who are reflective, rigid, orderly, systematic, and comfortable with routine.
  2. harm avoidance. High Scores: Indicates individuals who are cautious, fearful, socially inhibited, and prone to worry or depression.Low Scores: Indicates individuals who are confident, carefree, optimistic, relaxed, and resilient to stress.
  3. reward dependence. High Scores: Indicates individuals who are warm, empathetic, socially sensitive, and highly motivated by praise.Low Scores: Indicates individuals who are independent, practical, socially detached, and emotionally self-sufficient.
Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
WHO Quality of Life-BREF (WHOQOL-BREF)
Tidsramme: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
a 26-item survey by the World Health Organization that measures personal well-being across four core domains: physical health, psychological health, social relationships, and environment. Scores are scaled from 0 to 100, where higher numbers show a better quality of life.
Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
Sensory profile
Tidsramme: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)

a standardized questionnaire completed by caregivers, teachers, or individuals to evaluate how a person processes everyday sensory information (like touch, sound, and movement). It measures how a person's nervous system responds to sensory inputs and how those responses affect daily life. Results describe an individual in the following four areas: Seeking: Actively searches for extra sensory input (e.g., loves spinning, crashing into things, chewing objects, or loud music).

Sensitivity: Detects sensory input very quickly and easily, noticing small details (e.g., easily distracted by background noise or bright lights).

Avoiding: Actively tries to escape or prevent sensory input (e.g., covers ears in loud rooms, refuses certain clothing textures, or avoids crowds).

Low Registration: Misses or is slow to notice sensory input (e.g., doesn't respond to their name, seems clumsy, or doesn't notice pain/temperatures).
Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
Social responsiveness scale (SRS)
Tidsramme: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
a 65-item questionnaire that measures the severity of social impairment and autism spectrum-related traits. It evaluates how a person acts in real-life social settings. Higher scores represent greater impairment.
Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
Autism Spectrum Quotient (AQ)
Tidsramme: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
The Autism Spectrum Quotient (AQ) is a 50-item self-report questionnaire used to measure autistic traits in adults and teens. Scores range from 0 to 50. A score of 26 or higher suggests elevated autistic traits, while 32 or higher indicates a strong presence of these traits.
Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
Empathy Quotient (EQ)
Tidsramme: Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)
The Empathy Quotient (EQ) is a self-report questionnaire developed by psychologist Simon Baron-Cohen to measure a person's ability to understand others' thoughts and feel appropriate emotional responses. The standard test has 60 items (40 scored statements and 20 filler questions) spanning cognitive empathy, emotional reactivity, and social skills. Higher scores indicate higher empathy levels.
Time of the original assessment (data collected retrospectively from January 1, 2014 to March 21, 2023)

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Taiwan University Hospital

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. juli 2022

Primær færdiggørelse (Anslået)

31. december 2027

Studieafslutning (Anslået)

31. december 2027

Datoer for studieregistrering

Først indsendt

4. maj 2023

Først indsendt, der opfyldte QC-kriterier

23. maj 2023

Først opslået (Faktiske)

2. juni 2023

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

17. august 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

13. august 2026

Sidst verificeret

1. august 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • 202206027RINA

Plan for individuelle deltagerdata (IPD)

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