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Træningsintensitet og postprandielle effekter af at afbryde stillesiddende adfærd hos overvægtige voksne

21. september 2026 opdateret af: Muhammed Mustafa Atakan, Hacettepe University

Postprandiale kardiometaboliske effekter af at afbryde stillesiddende adfærd med motion af varierende intensitet hos raske overvægtige voksne

The purpose of this study is twofold: (1) to determine whether breaking up prolonged sitting with aerobic or sprint cycling breaks reduces postprandial blood glucose, insulin, CRP, and blood pressure, which are established risk markers for cardiometabolic diseases; and (2) to assess substrate oxidation during this period in order to identify which exercise condition promotes the greatest increase in fat oxidation.

Studieoversigt

Status

Rekruttering

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Sedentary behavior (SED) refers to activities such as sitting, lying down, or reclining that require energy expenditure of ≤1.5 MET during the time spent awake. Prolonged and continuous sedentary behavior leads to adverse effects such as abnormal postprandial metabolic responses, insulin resistance, vascular dysfunction, high blood pressure, increased carbohydrate oxidation, and inflammation. Epidemiological data also show that SED increases the risk of mortality, cardiovascular disease, type 2 diabetes, and certain types of cancer. Experimental studies have shown that 2-5 minutes of low- or moderate-intensity aerobic exercise performed every 20-30 minutes during the postprandial period improves cardiometabolic health by reducing glucose, insulin, and blood pressure during the postprandial period. On the other hand, it is known that short-term sprint interval exercise (SIE) increases insulin sensitivity by rapidly depleting muscle glycogen, improves glucose control, lowers blood pressure, and increases fat oxidation. With these effects, SIE may be a time-efficient method for interrupting SED. Although the cardiometabolic benefits of SIE and aerobic exercise interruptions (AEI) are known, there is a lack of studies comparing the effects of interrupting SED with these two exercise types of different intensities in preventing postprandial cardiometabolic dysfunction. In this context, the aim of the study is to compare the postprandial cardiometabolic effects of interrupting sedentary behavior with AIE and sprint exercise interruptions (SEI) in overweight but otherwise healthy women and men aged 30-45. In this randomized crossover trial, volunteers will participate in three trials: 1) AEI, 2) SEI, and 3) SED. There will be a minimum 4-day washout period between trials. In the SEI and AEI trials, exercise interruptions will be implemented every 30 minutes during the 7-hour sitting period, whereas in the SED trial, participants will remain seated continuously for the entire duration. In all conditions, two meals (breakfast and lunch) will be served 3 hours apart, and the trials will begin, after the breakfast meal is consumed. Venous blood samples for every 30 minutes of the first two hours following meals to measure glucose and to be taken hourly during the rest experiment will be used to analyze insulin, glucose, and C-reactive protein (CRP) levels. In addition, blood pressure will be measured hourly, and fat oxidation will be assessed at the baseline, 2nd, 5th, and 7th hours. The effects of the conditions on glucose and insulin will be evaluated using linear mixed models. A Two-Way (Trial x Number of Repeats) Analysis of Variance for Repeated Measures will be used to detect differences between conditions.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

18

Fase

  • Ikke anvendelig

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Studiesteder

  • Tyrkiet (Türkiye)
    • Beytepe
      • Ankara, Beytepe, Tyrkiet (Türkiye)
        • Rekruttering
        • Hacettepe Sports Science Faculty, Hacettepe Beytepe Clinic
        • Kontakt:
        • Ledende efterforsker:
          • Hikmet Sercan Toprakoğlu
        • Underforsker:
          • Seda Hanife Oğuz Baykal, Associate Professor
        • Underforsker:
          • Muhammed Mustafa Atakan, Associate Professor
        • Underforsker:
          • Yasemin Güzel, Doctoral faculty member
        • Underforsker:
          • Yiğitcan Karanfil, Doctoral faculty member
        • Underforsker:
          • İbrahim Türkel, Doctoral faculty member
        • Underforsker:
          • Şükran Nazan Koşar, Professor

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

30 år til 45 år (Voksen)

Tager imod sunde frivillige

Ja

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria

  • Being physically inactive (not doing at least 150 minutes/week of structured exercise).
  • Being sedentary (having a daily sedentary time/day for >7 hours).
  • Having a BMI between 25 and 29.9 kg/m2.
  • Having a history of regular menstrual cycles for female participants.
  • Having medical examination approval.

Exclusion Criteria

  • Taking any acute or chronic medication or supplement that may affect metabolism.
  • Having an acute or chronic illness that limits exercise (musculoskeletal problems, cardiovascular disorders, respiratory problems, etc.).
  • Consuming tobacco products.
  • Meeting 3 or more of the metabolic syndrome criteria (waist circumference of 102 cm or more in men, 88 cm or more in women, triglyceride level of 150 mg/dL or higher, HDL cholesterol level below 40 mg/dL in men and 50 mg/dL in women, blood pressure of 130/85 mmHg or higher, fasting blood glucose level of 100 mg/dL (5.6 mg/L) or higher).

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Forebyggelse
  • Tildeling: Randomiseret
  • Interventionel model: Crossover opgave
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Sedentary: Participants will remain seated for 7 h.

The sedentary condition will take place in a seated position. During the seated condition, volunteers will be seated at a typical desk chair at an appropriate height with hip and knee angles of ~90° and feet flat on the floor. The seating area will include a standard desk chair, a work desk, and the volunteers' personal laptops. Volunteers will be instructed prior to the visit to avoid behaviors such as fidgeting, excessive leg movements, and crossing their legs to minimize potential extraneous effects.
Andet: Sedentary Behaviour Intervention

Participants will remain seated for a total duration of 7 hours. During this period, they will be instructed to minimize excessive movement and will only be permitted to rise from the chair for voiding purposes.
Eksperimentel: Breaking up sitting with aerobic exercise interruptions

The protocol that will interrupt sitting with AEI will involve cycle exercises performed at 50% of Wattmax for 2 minutes. The W and rpm levels corresponding to 50% of Wattmax will be determined using the values recorded during the determination of Wattmax.
Andet: Aerobic Exercise Intervention

In the aerobic exercise condition, participants will perform 2 minutes of moderate-intensity (%50 Wattmax) continuous cycling.
Eksperimentel: Breaking up sitting with sprint exercise interruptions

The protocol that will interrupt sitting with SEI will involve cycle exercises performed at the maximum revolutions per minute achievable within 10 seconds. Immediately (2-3 seconds) before each SEI, volunteers will increase their pedal cadence to the maximum speed they can achieve, after which a pedal load will be applied to the bicycle ergometer and a sprint will be performed against the applied load for 10 seconds. During each sprint, the pedal load will be applied at %200 Wattmax level.
Andet: Sprint Exercise Intervention

In the sprint condition, participants will complete a 10-second sprint at %200 Wattmax level, as determined during the preliminary test.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Insulin
Tidsramme: 7 hour for each experimental condition

Postprandial insulin. Net incremental area under the curve and total area under the curve for each 7 h condition will be calculated for insulin.
7 hour for each experimental condition

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Glucose
Tidsramme: 7 hour for each experimental condition

Postprandial glucose. Net incremental area under the curve and total area under the curve for each 7 hour condition will be calculated for glucose.
7 hour for each experimental condition
CRP
Tidsramme: 7 hour

Postprandial CRP. Net incremental area under the curve and total area under the curve for each 7 h condition will be calculated for CRP.
7 hour
Substrate oxidation
Tidsramme: 0, 2th, 5th, 7th hours

Postprandial substrate oxidation. During each experimental visit, for 7 hours, volunteers' respiratory data will be collected using a direct calorimeter with canopy hood in lying position for 10 minutes at 0, 2th, 5th, and 7th hours. The volunteers' resting fat and carbohydrate oxidations will be determined from the obtained data.
0, 2th, 5th, 7th hours
Blood pressure
Tidsramme: 7 hour

Postprandial arterial blood pressure will be measured hourly for 7 h using an automatic blood pressure monitor with a cuff of appropriate size. The systolic and diastolic BP values measured will be recorded, and the mean arterial pressure will be calculated.
7 hour

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Hacettepe University

Efterforskere

  • Ledende efterforsker: Şükran Nazan Koşar, Professor, Hacettepe University

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. september 2026

Primær færdiggørelse (Anslået)

20. november 2026

Studieafslutning (Anslået)

15. december 2026

Datoer for studieregistrering

Først indsendt

24. september 2025

Først indsendt, der opfyldte QC-kriterier

13. november 2025

Først opslået (Faktiske)

17. november 2025

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

24. september 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

21. september 2026

Sidst verificeret

1. august 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • SBA 25/679

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

IPD-planbeskrivelse

We do not plan to share IPD with other researchers due to privacy concerns and ethical restrictions outlined in the study's informed consent procedure.

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

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Ingen

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Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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