A High-Intensity Multi-Component Agility Intervention Improves Parkinson's Patients' Clinical and Motor Symptoms

Agility Training in Parkinson's Disease

Sponsors

Lead sponsor: Somogy Megyei Kaposi Mór Teaching Hospital

Collaborator: University Medical Center Groningen

Source Somogy Megyei Kaposi Mór Teaching Hospital
Brief Summary

To determine the effects of an unusually highly intensity and individualized sensorimotor and visuomotor agility exercise program on non-demented PD patients' clinical symptoms, mobility, and postural stability.

Detailed Description

Design: Intervention study

Setting: Outpatient rehabilitation center

Participants: 55 Parkinson's disease (PD) patients completed the trial and 42 serves as comparison healthy controls

Intervention: An initial screening established specific dysfunctions of PD patients with Hoehn-Yahr stage 2-3 who were then randomly assigned to standard care (n = 20) or standard care plus at-limit intensity, individualized agility program (15 sessions, 3 weeks, n = 35).

Main outcome measures: Movement Disorder Society Unified Parkinson Disease Rating Scale, Motor Experiences of Daily Living, a measure sensitive to changes in a broad spectrum of PD symptoms

In group time, repeated measurements of variance analysis were compared to the picture parkinson's disease based on MDS-UPDRS M-EDL, Beck depression score, PDQ-39, EQ5D VAS, Schwab & England scale. The TUG test and 12 static posturographic measurements are compared and compared to the healthy group as a standard.

An at-limit and individualized sensorimotor and visuomotor agility exercise program vs. standard care, will improve non-demented, stage 2-3 PD patients' clinical symptoms, mobility, and postural stability by functionally meaningful margins.

Overall Status Completed
Start Date May 11, 2015
Completion Date June 30, 2017
Primary Completion Date May 31, 2017
Phase N/A
Study Type Interventional
Primary Outcome
Measure Time Frame
EQ5D-5L 0-5 scale (3 week-long, higher number is better)
Enrollment 3
Condition
Intervention

Intervention type: Other

Intervention name: Exercise therapy

Description: 3-week-long intervention, administered daily, targeted postural instability and mobility using at-limit intensity sensorimotor and visuomotor agility training

Arm group label: Exercise therapy

Other name: Control

Eligibility

Criteria:

Inclusion Criteria:

- Parkinson's disease

- Hoenh Yahr scale of 2-3

- Instability problem

Exclusion Criteria:

- Severe heart problems

- Severe demeanor

- Alcoholism

- Drug problems

Gender: All

Minimum age: 55 Years

Maximum age: 85 Years

Healthy volunteers: Accepts Healthy Volunteers

Location
facility Somogy Megyei Kaposi Mór Teaching Hospital
Location Countries

Hungary

Verification Date

June 2017

Responsible Party

Responsible party type: Principal Investigator

Investigator affiliation: Somogy Megyei Kaposi Mór Teaching Hospital

Investigator full name: Tollár József

Investigator title: Principal investigator

Keywords
Has Expanded Access No
Condition Browse
Number Of Arms 3
Arm Group

Arm group label: Exercise therapy

Arm group type: Experimental

Description: Parkinson's disease group that receive 3 weeks of intensive exercise therapy in a rehabilitation center.

Arm group label: Control

Arm group type: No Intervention

Description: Parkinson's disease control group that will not receive exercise treatment.

Arm group label: Healthy

Arm group type: No Intervention

Description: A healthy group whose results will be compared with Parkinson's disease groups.

Patient Data No
Study Design Info

Allocation: Randomized

Intervention model: Parallel Assignment

Intervention model description: The single-arm, 3-week-long intervention, administered daily, targeted postural instability and mobility using at-limit intensity sensorimotor and visuomotor agility training (n = 35, 17 males) conceptualized but seldom implemented previously. Each of the 15 training sessions lasted 60 minutes. Patients performed each exercise under increasingly difficult conditions and speed according to principles of periodization. All patients kept an exercise log detailing the positive and negative effects of the intervention on clinical and motor symptoms. The logs and attendance were checked daily. The no-intervention control, consisting of PD patients (n = 20, 12 males) received unsupervised standard care, consisting of the prescribed medications and daily, unsupervised 30 minutes of exercises at home.

Primary purpose: Treatment

Masking: Single (Investigator)

Source: ClinicalTrials.gov