GO PRP: Assessing the Efficacy of Intra Articular Injection of Platelets Rich Plasma for Gonarthrosis Treatment in Routine Care

Inclusion Criteria:

• Men and women 20 to 80 years
• Gonarthrosis diagnostic objectified by the criteria of the American College of Rheumatology
• Joint pain for more than 6 months
• Answer "moderate" to the question about pain walking on flat ground
• Answer "moderate" to the question about trouble walking on flat ground
• Osteoarthritis stage 2 or 3 on the scale of Kellgren Lawrence (objectified radiography) within 6 months previous inclusion
• Axial deformation of less than or equal to 5 ° lower limbs
• Informed consent signed by the patient
• HB> 10g / dl
• Beta-HCG negative at baseline
• Ability to perform the procedures in the follow-up (50 not walk on a flat surface and up / down stairs).
• Being affiliated to a system of health insurance

Exclusion criteria:

• Axial deformation > 5 °
• Ligamentous instability
• Significant injuries or target knee or knee surgery contralateral side in 12 months previous the inclusion visit
• Ligament reconstruction in the 12 months précédants the inclusion visit
• Need a cane or assistance to move
• BMI> 35
• Thrombocytopenia <150 G / L
• Thrombocytosis> 450 G / L
• Known thrombopathy
• Anemia HB <10g / dl
• Active infections to HIV 1 and 2, Agp24, HCV Ab, Ag and HbS AcHbc, Ac HTLV I and II, TPHA
• Chronic treatment with corticosteroids per os or older than 2 weeks
• Injection intra-articular corticosteroid of less than 2 months
• Intra-articular injection of hyaluronic acid of less than 6 months
• NSAIDs or antiplatelet agent of less than 15 days
• Inability to stop NSAIDs (including aspirin) 15 days before the injection and the week following the injection
• Fever or recent illness
• Autoimmune diseases
• Inflammatory arthritis
• Immune deficiency
• Infectious diseases
• Pregnant women
• Adults legally protected (under guardianship and trusteeship)
• People simultaneously participating in other biomedical research16. Inability