Estudo de Tratamento Multimodal de Crianças com Transtorno de Déficit de Atenção e Hiperatividade (MTA) (MTA)
28 de setembro de 2015 atualizado por: NYU Langone Health
Estudo de tratamento multimodal de crianças com TDAH
Este estudo é uma continuação do Estudo de Tratamento Multimodal de Crianças com Transtorno de Déficit de Atenção e Hiperatividade (Estudo MTA). Continuação O objetivo 1 é rastrear a persistência dos efeitos relacionados à intervenção à medida que a amostra MTA amadurece até meados da adolescência, incluindo padrões subsequentes de saúde mental e utilização de serviços relacionados à escola em função da experiência de tratamento MTA (atribuição de tratamento) e resultado (grau do sucesso do tratamento aos 14 meses). O objetivo 2 é testar hipóteses específicas sobre preditores, mediadores e moderadores de resultados de longo prazo entre crianças com TDAH (por exemplo, comorbidade; funcionamento familiar; habilidades cognitivas; relações com pares) que podem influenciar o funcionamento do adolescente (seja independente ou por meio do tratamento inicial atribuição e/ou resultados de tratamento de 14 meses); e comparar como esses preditores, mediadores e moderadores são semelhantes ou diferentes dentro do grupo de comparação normal. O objetivo 3 é rastrear os padrões de risco e fatores de proteção (incluindo sua mediação ou moderação por atribuição de tratamento inicial e/ou resultado) envolvidos nos estágios iniciais e subseqüentes do desenvolvimento de transtornos relacionados a substâncias e comportamento antissocial. O objetivo 4 é examinar o efeito da designação do tratamento inicial e o grau de sucesso do tratamento no desempenho acadêmico posterior, desempenho, conduta escolar, tendência ao abandono escolar e outros resultados escolares adversos.
No projeto MTA original, os pacientes foram aleatoriamente designados para 1 de 4 condições de tratamento: (1) apenas medicação; (2) apenas psicossocial; (3) combinados (medicamentoso e psicossocial); ou (4) Condição de avaliação e encaminhamento. Todos, exceto o último, foram tratados intensivamente por 14 meses, com avaliações para todos os indivíduos no início do estudo, 3, 9, 14 e 24 meses. O projeto original do MTA fornece, portanto, acompanhamento de curto prazo (10 meses após o tratamento) em 24 meses. Essa continuação estende o acompanhamento para avaliações aos 36, 60 e 84 meses após o tratamento.
Uma criança pode ser elegível para este estudo se:
Tem de 7 a 9 anos e tem Transtorno de Déficit de Atenção e Hiperatividade (TDAH).
Visão geral do estudo
Status
Concluído
Condições
Descrição detalhada
Este estudo é uma continuação do Estudo de Tratamento Multimodal de Crianças com Transtorno de Déficit de Atenção e Hiperatividade (Estudo MTA). Continuação O objetivo 1 é rastrear a persistência dos efeitos relacionados à intervenção à medida que a amostra MTA amadurece até meados da adolescência, incluindo padrões subsequentes de saúde mental e utilização de serviços relacionados à escola em função da experiência de tratamento MTA (atribuição de tratamento) e resultado (grau do sucesso do tratamento aos 14 meses). O objetivo 2 é testar hipóteses específicas sobre preditores, mediadores e moderadores de resultados de longo prazo entre crianças com TDAH (por exemplo, comorbidade; funcionamento familiar; habilidades cognitivas; relações com pares) que podem influenciar o funcionamento do adolescente (seja independente ou por meio do tratamento inicial atribuição e/ou resultados de tratamento de 14 meses); e comparar como esses preditores, mediadores e moderadores são semelhantes ou diferentes dentro do grupo de comparação normal. O objetivo 3 é rastrear os padrões de risco e fatores de proteção (incluindo sua mediação ou moderação por atribuição de tratamento inicial e/ou resultado) envolvidos nos estágios iniciais e subseqüentes do desenvolvimento de transtornos relacionados a substâncias e comportamento antissocial. O objetivo 4 é examinar o efeito da designação do tratamento inicial e o grau de sucesso do tratamento no desempenho acadêmico posterior, desempenho, conduta escolar, tendência ao abandono escolar e outros resultados escolares adversos.
No projeto MTA original, os pacientes foram aleatoriamente designados para 1 de 4 condições de tratamento: (1) apenas medicação; (2) apenas psicossocial; (3) combinados (medicamentoso e psicossocial); ou (4) Condição de avaliação e encaminhamento. Todos, exceto o último, foram tratados intensivamente por 14 meses, com avaliações para todos os indivíduos no início do estudo, 3, 9, 14 e 24 meses. O projeto original do MTA fornece, portanto, acompanhamento de curto prazo (10 meses após o tratamento) em 24 meses. Essa continuação estende o acompanhamento para avaliações aos 36, 60 e 84 meses após o tratamento.
Tipo de estudo
Intervencional
Estágio
- Fase 4
Critérios de participação
Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.
Critérios de elegibilidade
Idades elegíveis para estudo
5 anos a 7 anos (Filho)
Aceita Voluntários Saudáveis
N/D
Gêneros Elegíveis para o Estudo
Tudo
Descrição
Critério de inclusão:
-
Os pacientes devem ter:
Transtorno de Déficit de Atenção e Hiperatividade (TDAH) rigorosamente diagnosticado.
Plano de estudo
Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.
Como o estudo é projetado?
Detalhes do projeto
- Finalidade Principal: Tratamento
- Alocação: Randomizado
Colaboradores e Investigadores
É aqui que você encontrará pessoas e organizações envolvidas com este estudo.
Patrocinador
Colaboradores
Investigadores
- Investigador principal: Howard B. Abikoff, PhD
- Investigador principal: C. Keith Conners
- Investigador principal: Laurence L. Greenhill, MD
- Investigador principal: Stephen P. Hinshaw, PhD
- Investigador principal: William E. Pelham, PhD
- Investigador principal: James M. Swanson, PhD
Publicações e links úteis
A pessoa responsável por inserir informações sobre o estudo fornece voluntariamente essas publicações. Estes podem ser sobre qualquer coisa relacionada ao estudo.
Publicações Gerais
- Epstein JN, Conners CK, Hervey AS, Tonev ST, Arnold LE, Abikoff HB, Elliott G, Greenhill LL, Hechtman L, Hoagwood K, Hinshaw SP, Hoza B, Jensen PS, March JS, Newcorn JH, Pelham WE, Severe JB, Swanson JM, Wells K, Vitiello B, Wigal T; MTA Cooperative Study Group. Assessing medication effects in the MTA study using neuropsychological outcomes. J Child Psychol Psychiatry. 2006 May;47(5):446-56. doi: 10.1111/j.1469-7610.2005.01469.x.
- Molina BSG, Hinshaw SP, Swanson JM, Arnold LE, Vitiello B, Jensen PS, Epstein JN, Hoza B, Hechtman L, Abikoff HB, Elliott GR, Greenhill LL, Newcorn JH, Wells KC, Wigal T, Gibbons RD, Hur K, Houck PR; MTA Cooperative Group. The MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study. J Am Acad Child Adolesc Psychiatry. 2009 May;48(5):484-500. doi: 10.1097/CHI.0b013e31819c23d0.
- Kolko DJ, Bukstein OG, Barron J. Methylphenidate and behavior modification in children with ADHD and comorbid ODD or CD: main and incremental effects across settings. J Am Acad Child Adolesc Psychiatry. 1999 May;38(5):578-86. doi: 10.1097/00004583-199905000-00020.
- Epstein JN, Conners CK, Erhardt D, Arnold LE, Hechtman L, Hinshaw SP, Hoza B, Newcorn JH, Swanson JM, Vitiello B. Familial aggregation of ADHD characteristics. J Abnorm Child Psychol. 2000 Dec;28(6):585-94. doi: 10.1023/a:1005187216138.
- Hoza B, Owens JS, Pelham WE, Swanson JM, Conners CK, Hinshaw SP, Arnold LE, Kraemer HC. Parent cognitions as predictors of child treatment response in attention-deficit/hyperactivity disorder. J Abnorm Child Psychol. 2000 Dec;28(6):569-83. doi: 10.1023/a:1005135232068.
- Paule MG, Rowland AS, Ferguson SA, Chelonis JJ, Tannock R, Swanson JM, Castellanos FX. Attention deficit/hyperactivity disorder: characteristics, interventions and models. Neurotoxicol Teratol. 2000 Sep-Oct;22(5):631-51. doi: 10.1016/s0892-0362(00)00095-7.
- Pelham WE, Gnagy EM, Greiner AR, Hoza B, Hinshaw SP, Swanson JM, Simpson S, Shapiro C, Bukstein O, Baron-Myak C, McBurnett K. Behavioral versus behavioral and pharmacological treatment in ADHD children attending a summer treatment program. J Abnorm Child Psychol. 2000 Dec;28(6):507-25. doi: 10.1023/a:1005127030251.
- Abikoff H. Tailored psychosocial treatments for ADHD: the search for a good fit. J Clin Child Psychol. 2001 Mar;30(1):122-5. doi: 10.1207/S15374424JCCP3001_14.
- Hoza B. Psychosocial treatment issues in the MTA: a reply to Greene and Ablon. J Clin Child Psychol. 2001 Mar;30(1):126-30. doi: 10.1207/S15374424JCCP3001_15.
- Jensen PS, Hinshaw SP, Swanson JM, Greenhill LL, Conners CK, Arnold LE, Abikoff HB, Elliott G, Hechtman L, Hoza B, March JS, Newcorn JH, Severe JB, Vitiello B, Wells K, Wigal T. Findings from the NIMH Multimodal Treatment Study of ADHD (MTA): implications and applications for primary care providers. J Dev Behav Pediatr. 2001 Feb;22(1):60-73. doi: 10.1097/00004703-200102000-00008.
- Marcus, S. M., & Gibbons, R. D. (2001). Estimating the efficacy of receiving treatment in randomized clinical trials with noncompliance. Health Services and Outcomes Research Methodology, 2(3-4), 247-258.
- Newcorn JH, Halperin JM, Jensen PS, Abikoff HB, Arnold LE, Cantwell DP, Conners CK, Elliott GR, Epstein JN, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Kraemer HC, Pelham WE, Severe JB, Swanson JM, Wells KC, Wigal T, Vitiello B. Symptom profiles in children with ADHD: effects of comorbidity and gender. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):137-46. doi: 10.1097/00004583-200102000-00008.
- Johnston C, Murray C, Hinshaw SP, William EP Jr, Hoza B. Responsiveness in interactions of mothers and sons with ADHD: relations to maternal and child characteristics. J Abnorm Child Psychol. 2002 Feb;30(1):77-88. doi: 10.1023/a:1014235200174.
- Arnold LE, Elliot M, Sachs L, Bird H, Kraemer HC, Wells KC, Abikoff HB, Comarda A, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hindshaw SP, Hoza B, Jensen PS, March JS, Newcorn JH, Pelham WE, Severe JB, Swanson JM, Vitiello B, Wigal T. Effects of ethnicity on treatment attendance, stimulant response/dose, and 14-month outcome in ADHD. J Consult Clin Psychol. 2003 Aug;71(4):713-27. doi: 10.1037/0022-006x.71.4.713.
- Hoza B, Gerdes AC, Hinshaw SP, Arnold LE, Pelham WE Jr, Molina BS, Abikoff HB, Epstein JN, Greenhill LL, Hechtman L, Odbert C, Swanson JM, Wigal T. Self-perceptions of competence in children with ADHD and comparison children. J Consult Clin Psychol. 2004 Jun;72(3):382-91. doi: 10.1037/0022-006X.72.3.382.
- MTA Cooperative Group. National Institute of Mental Health Multimodal Treatment Study of ADHD follow-up: 24-month outcomes of treatment strategies for attention-deficit/hyperactivity disorder. Pediatrics. 2004 Apr;113(4):754-61. doi: 10.1542/peds.113.4.754.
- Newcorn, J. H. (2004). Comorbidity of ADHD and disruptive behavior disorders: Prevalence, impact, and management options. Drug Benefit Trends, 16(8), 431-436.
- Galanter, C. A., Pagar, D. L., Davies, M., Li, W., Carlson, G. A., Abikoff, H. B., . . . Jensen, P. S. (2005). ADHD and manic symptoms: Diagnostic and treatment implications. Clinical Neuroscience Research, 5(5-6), 283-294.
- Hechtman, L., Etcovitch, J., Platt, R., Arnold, L. E., Abikoff, H. B., Newcorn, J. H., . . . Wigal, T. (2005). Does multimodal treatment of ADHD decrease other diagnoses? Clinical Neuroscience Research, 5(5-6), 273-282.
- Santosh, P. J., Taylor, E., Swanson, J., Wigal, T., Chuang, S., Davies, M., . . . Posner, M. (2005). Refining the diagnoses of inattention and overactivity syndromes: A reanalysis of the multimodal treatment study of attention deficit hyperactivity disorder (ADHD) based on ICD-10 criteria for hyperkinetic disorder. Clinical Neuroscience Research, 5(5-6), 307-314.
- Hervey AS, Epstein JN, Curry JF, Tonev S, Eugene Arnold L, Keith Conners C, Hinshaw SP, Swanson JM, Hechtman L. Reaction time distribution analysis of neuropsychological performance in an ADHD sample. Child Neuropsychol. 2006 Apr;12(2):125-40. doi: 10.1080/09297040500499081.
- Gerdes AC, Hoza B, Arnold LE, Hinshaw SP, Wells KC, Hechtman L, Greenhill LL, Swanson JM, Pelham WE, Wigal T. Child and parent predictors of perceptions of parent--child relationship quality. J Atten Disord. 2007 Jul;11(1):37-48. doi: 10.1177/1087054706295664.
- Gerdes AC, Hoza B, Arnold LE, Pelham WE, Swanson JM, Wigal T, Jensen PS. Maternal depressive symptomatology and parenting behavior: exploration of possible mediators. J Abnorm Child Psychol. 2007 Oct;35(5):705-14. doi: 10.1007/s10802-007-9134-3. Epub 2007 Aug 3.
- Hinshaw SP. Moderators and mediators of treatment outcome for youth with ADHD: understanding for whom and how interventions work. Ambul Pediatr. 2007 Jan-Feb;7(1 Suppl):91-100. doi: 10.1016/j.ambp.2006.04.012.
- Hinshaw SP. Moderators and mediators of treatment outcome for youth with ADHD: understanding for whom and how interventions work. J Pediatr Psychol. 2007 Jul;32(6):664-75. doi: 10.1093/jpepsy/jsl055. Epub 2007 Jan 29.
- Laforett DR, Murray DW, Kollins SH. Psychosocial treatments for preschool-aged children with Attention-Deficit Hyperactivity Disorder. Dev Disabil Res Rev. 2008;14(4):300-10. doi: 10.1002/ddrr.36.
- Langberg JM, Epstein JN, Altaye M, Molina BS, Arnold LE, Vitiello B. The transition to middle school is associated with changes in the developmental trajectory of ADHD symptomatology in young adolescents with ADHD. J Clin Child Adolesc Psychol. 2008 Jul;37(3):651-63. doi: 10.1080/15374410802148095.
- Mrug S, Hoza B, Gerdes AC, Hinshaw S, Arnold LE, Hechtman L, Pelham WE. Discriminating between children with ADHD and classmates using peer variables. J Atten Disord. 2009 Jan;12(4):372-80. doi: 10.1177/1087054708314602. Epub 2008 Apr 3.
- Jones HA, Epstein JN, Hinshaw SP, Owens EB, Chi TC, Arnold LE, Hoza B, Wells KC. Ethnicity as a moderator of treatment effects on parent--child interaction for children with ADHD. J Atten Disord. 2010 May;13(6):592-600. doi: 10.1177/1087054709332158. Epub 2009 Jun 16.
- Langberg JM, Epstein JN, Simon JO, Loren RE, Arnold LE, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Pelham WE, Swanson JM, Wigal T. Parental Agreement on ADHD Symptom-Specific and Broadband Externalizing Ratings of Child Behavior. J Emot Behav Disord. 2010 Mar;18(1):41-50. doi: 10.1177/1063426608330792.
- Mikami AY, Hinshaw SP, Arnold LE, Hoza B, Hechtman L, Newcorn JH, Abikoff HB. Bulimia nervosa symptoms in the multimodal treatment study of children with ADHD. Int J Eat Disord. 2010 Apr;43(3):248-59. doi: 10.1002/eat.20692.
- Murray DW. Treatment of preschoolers with attention-deficit/hyperactivity disorder. Curr Psychiatry Rep. 2010 Oct;12(5):374-81. doi: 10.1007/s11920-010-0142-6.
- Rabiner DL, Murray DW, Rosen L, Hardy K, Skinner A, Underwood M. Instability in teacher ratings of children's inattentive symptoms: implications for the assessment of ADHD. J Dev Behav Pediatr. 2010 Apr;31(3):175-80. doi: 10.1097/DBP.0b013e3181d5a2d8.
- Vaughn AJ, Epstein JN, Rausch J, Altaye M, Langberg J, Newcorn JH, Hinshaw SP, Hechtman L, Arnold LE, Swanson JM, Wigal T. Relation between outcomes on a continuous performance test and ADHD symptoms over time. J Abnorm Child Psychol. 2011 Aug;39(6):853-64. doi: 10.1007/s10802-011-9501-y.
- Mrug S, Molina BS, Hoza B, Gerdes AC, Hinshaw SP, Hechtman L, Arnold LE. Peer rejection and friendships in children with Attention-Deficit/Hyperactivity Disorder: contributions to long-term outcomes. J Abnorm Child Psychol. 2012 Aug;40(6):1013-26. doi: 10.1007/s10802-012-9610-2.
- Shaw M, Hodgkins P, Caci H, Young S, Kahle J, Woods AG, Arnold LE. A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: effects of treatment and non-treatment. BMC Med. 2012 Sep 4;10:99. doi: 10.1186/1741-7015-10-99.
- Vitiello B, Elliott GR, Swanson JM, Arnold LE, Hechtman L, Abikoff H, Molina BS, Wells K, Wigal T, Jensen PS, Greenhill LL, Kaltman JR, Severe JB, Odbert C, Hur K, Gibbons R. Blood pressure and heart rate over 10 years in the multimodal treatment study of children with ADHD. Am J Psychiatry. 2012 Feb;169(2):167-77. doi: 10.1176/appi.ajp.2011.10111705.
- Owens EB, Hinshaw SP. Perinatal problems and psychiatric comorbidity among children with ADHD. J Clin Child Adolesc Psychol. 2013;42(6):762-8. doi: 10.1080/15374416.2013.785359. Epub 2013 Apr 14.
- Greenfield B, Hechtman L, Stehli A, Wigal T. Sexual maturation among youth with ADHD and the impact of stimulant medication. Eur Child Adolesc Psychiatry. 2014 Sep;23(9):835-9. doi: 10.1007/s00787-014-0521-3. Epub 2014 Feb 2.
- A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. The MTA Cooperative Group. Multimodal Treatment Study of Children with ADHD. Arch Gen Psychiatry. 1999 Dec;56(12):1073-86. doi: 10.1001/archpsyc.56.12.1073.
- Richters JE, Arnold LE, Jensen PS, Abikoff H, Conners CK, Greenhill LL, Hechtman L, Hinshaw SP, Pelham WE, Swanson JM. NIMH collaborative multisite multimodal treatment study of children with ADHD: I. Background and rationale. J Am Acad Child Adolesc Psychiatry. 1995 Aug;34(8):987-1000. doi: 10.1097/00004583-199508000-00008.
- Greenhill LL, Abikoff HB, Arnold LE, Cantwell DP, Conners CK, Elliott G, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, March JS, Newcorn J, Pelham WE, Severe JB, Swanson JM, Vitiello B, Wells K. Medication treatment strategies in the MTA Study: relevance to clinicians and researchers. J Am Acad Child Adolesc Psychiatry. 1996 Oct;35(10):1304-13. doi: 10.1097/00004583-199610000-00017.
- Arnold, L. E., Abikoff, H. B., Cantwell, D. P., Conners, C. K., Elliott, G. R., Greenhill, L. L.,Hechtman, L., Hinshaw, S.P., Hoza B., Jensen, P.S., Kraemer, H.C, March, J.S., Newcorn, J.H., Pelham, W.E., Richters, J.E., Schiller, E., Severe, J.B., Swanson, J.M., Vereen, D., Wells, K.C. (1997). NIMH collaborative multimodal treatment study of children with ADHD (MTA): Design, methodology, and protocol evolution. Journal of Attention Disorders, 2(3), 141-158.
- Arnold LE, Abikoff HB, Cantwell DP, Conners CK, Elliott G, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Newcorn JH, Pelham WE, Richters JE, Schiller E, Severe JB, Swanson JM, Vereen D, Wells KC. National Institute of Mental Health Collaborative Multimodal Treatment Study of Children with ADHD (the MTA). Design challenges and choices. Arch Gen Psychiatry. 1997 Sep;54(9):865-70. doi: 10.1001/archpsyc.1997.01830210113015.
- Hinshaw, S. P., March, J. S., Abikoff, H., Arnold, L. E., Cantwell, D. P., Conners, C. K., . . . Wigal, T. (1997). Comprehensive assessment of childhood attention-deficit hyperactivity disorder in the context of a multisite, multimodal clinical trial. Journal of Attention Disorders, 1(4), 217-234.
- Moderators and mediators of treatment response for children with attention-deficit/hyperactivity disorder: the Multimodal Treatment Study of children with Attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 1999 Dec;56(12):1088-96. doi: 10.1001/archpsyc.56.12.1088.
- Jensen PS. Fact versus fancy concerning the multimodal treatment study for attention-deficit hyperactivity disorder. Can J Psychiatry. 1999 Dec;44(10):975-80. doi: 10.1177/070674379904401003.
- Pelham WE Jr. The NIMH multimodal treatment study for attention-deficit hyperactivity disorder: just say yes to drugs alone? Can J Psychiatry. 1999 Dec;44(10):981-90. doi: 10.1177/070674379904401004.
- Hinshaw SP, Owens EB, Wells KC, Kraemer HC, Abikoff HB, Arnold LE, Conners CK, Elliott G, Greenhill LL, Hechtman L, Hoza B, Jensen PS, March JS, Newcorn JH, Pelham WE, Swanson JM, Vitiello B, Wigal T. Family processes and treatment outcome in the MTA: negative/ineffective parenting practices in relation to multimodal treatment. J Abnorm Child Psychol. 2000 Dec;28(6):555-68. doi: 10.1023/a:1005183115230.
- March JS, Swanson JM, Arnold LE, Hoza B, Conners CK, Hinshaw SP, Hechtman L, Kraemer HC, Greenhill LL, Abikoff HB, Elliott LG, Jensen PS, Newcorn JH, Vitiello B, Severe J, Wells KC, Pelham WE. Anxiety as a predictor and outcome variable in the multimodal treatment study of children with ADHD (MTA). J Abnorm Child Psychol. 2000 Dec;28(6):527-41. doi: 10.1023/a:1005179014321.
- Wells KC, Pelham WE, Kotkin RA, Hoza B, Abikoff HB, Abramowitz A, Arnold LE, Cantwell DP, Conners CK, Del Carmen R, Elliott G, Greenhill LL, Hechtman L, Hibbs E, Hinshaw SP, Jensen PS, March JS, Swanson JM, Schiller E. Psychosocial treatment strategies in the MTA study: rationale, methods, and critical issues in design and implementation. J Abnorm Child Psychol. 2000 Dec;28(6):483-505. doi: 10.1023/a:1005174913412.
- Conners CK, Epstein JN, March JS, Angold A, Wells KC, Klaric J, Swanson JM, Arnold LE, Abikoff HB, Elliott GR, Greenhill LL, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, Newcorn JH, Pelham WE, Severe JB, Vitiello B, Wigal T. Multimodal treatment of ADHD in the MTA: an alternative outcome analysis. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):159-67. doi: 10.1097/00004583-200102000-00010.
- Greenhill LL, Swanson JM, Vitiello B, Davies M, Clevenger W, Wu M, Arnold LE, Abikoff HB, Bukstein OG, Conners CK, Elliott GR, Hechtman L, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Newcorn JH, Severe JB, Wells K, Wigal T. Impairment and deportment responses to different methylphenidate doses in children with ADHD: the MTA titration trial. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):180-7. doi: 10.1097/00004583-200102000-00012.
- Jensen PS, Hinshaw SP, Kraemer HC, Lenora N, Newcorn JH, Abikoff HB, March JS, Arnold LE, Cantwell DP, Conners CK, Elliott GR, Greenhill LL, Hechtman L, Hoza B, Pelham WE, Severe JB, Swanson JM, Wells KC, Wigal T, Vitiello B. ADHD comorbidity findings from the MTA study: comparing comorbid subgroups. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):147-58. doi: 10.1097/00004583-200102000-00009.
- Swanson JM, Kraemer HC, Hinshaw SP, Arnold LE, Conners CK, Abikoff HB, Clevenger W, Davies M, Elliott GR, Greenhill LL, Hechtman L, Hoza B, Jensen PS, March JS, Newcorn JH, Owens EB, Pelham WE, Schiller E, Severe JB, Simpson S, Vitiello B, Wells K, Wigal T, Wu M. Clinical relevance of the primary findings of the MTA: success rates based on severity of ADHD and ODD symptoms at the end of treatment. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):168-79. doi: 10.1097/00004583-200102000-00011.
- Vitiello B, Severe JB, Greenhill LL, Arnold LE, Abikoff HB, Bukstein OG, Elliott GR, Hechtman L, Jensen PS, Hinshaw SP, March JS, Newcorn JH, Swanson JM, Cantwell DP. Methylphenidate dosage for children with ADHD over time under controlled conditions: lessons from the MTA. J Am Acad Child Adolesc Psychiatry. 2001 Feb;40(2):188-96. doi: 10.1097/00004583-200102000-00013.
- Wells KC. Comprehensive versus matched psychosocial treatment in the MTA study: conceptual and empirical issues. J Clin Child Psychol. 2001 Mar;30(1):131-5. doi: 10.1207/S15374424JCCP3001_16.
- Abikoff H, Arnold LE, Newcorn JH, Elliott GR, Hechtman L, Severe JB, Wigal T, Shapiro C, Cantwell DP, Conners CK, Greenhill LL, Hinshaw SP, Hoza B, Jensen PS, Kraemer HC, March JS, Pelham WE, Swanson JM, Vitiello B, Wells KC. Emergency/Adjunct services and attrition prevention for randomized clinical trials in children: the MTA manual-based solution. J Am Acad Child Adolesc Psychiatry. 2002 May;41(5):498-504. doi: 10.1097/00004583-200205000-00006.
- Swanson JM, Arnold LE, Vitiello B, Abikoff HB, Wells KC, Pelham WE, March JS, Hinshaw SP, Hoza B, Epstein JN, Elliott GR, Greenhill LL, Hechtman L, Jensen PS, Kraemer HC, Kotkin R, Molina B, Newcorn JH, Owens EB, Severe J, Hoagwood K, Simpson S, Wigal T, Hanley T; MTA Group. Multimodal Treatment of Children with Attention Deficit Hyperactivity Disorder. Response to commentary on the multimodal treatment study of ADHD (MTA): mining the meaning of the MTA. J Abnorm Child Psychol. 2002 Aug;30(4):327-32. doi: 10.1023/a:1015709706388.
- Galanter CA, Carlson GA, Jensen PS, Greenhill LL, Davies M, Li W, Chuang SZ, Elliott GR, Arnold LE, March JS, Hechtman L, Pelham WE, Swanson JM. Response to methylphenidate in children with attention deficit hyperactivity disorder and manic symptoms in the multimodal treatment study of children with attention deficit hyperactivity disorder titration trial. J Child Adolesc Psychopharmacol. 2003 Summer;13(2):123-36. doi: 10.1089/104454603322163844.
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- Stevens J, Kelleher K, Greenhouse J, Chen G, Xiang H, Kaizar E, Jensen PS, Arnold LE. Empirical evaluation of the generalizability of the sample from the multimodal treatment study for ADHD. Adm Policy Ment Health. 2007 May;34(3):221-32. doi: 10.1007/s10488-006-0097-4. Epub 2006 Oct 20.
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Datas de registro do estudo
Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.
Datas Principais do Estudo
Início do estudo
1 de setembro de 1998
Conclusão do estudo
1 de novembro de 1999
Datas de inscrição no estudo
Enviado pela primeira vez
2 de novembro de 1999
Enviado pela primeira vez que atendeu aos critérios de CQ
2 de novembro de 1999
Primeira postagem (Estimativa)
3 de novembro de 1999
Atualizações de registro de estudo
Última Atualização Postada (Estimativa)
29 de setembro de 2015
Última atualização enviada que atendeu aos critérios de controle de qualidade
28 de setembro de 2015
Última verificação
1 de setembro de 2015
Mais Informações
Termos relacionados a este estudo
Palavras-chave
- Filho
- Fatores de risco
- Conhecimento
- Fêmea
- Humano
- Macho
- Adolescência
- Resultado do tratamento
- Terapia de Modalidade Combinada
- Transtorno de Déficit de Atenção com Hiperatividade
- Grupo de Pares
- Transtorno de Déficit de Atenção com Hiperatividade -- *terapia
- Transtorno de déficit de atenção com hiperatividade - terapia medicamentosa
- Transtorno de Déficit de Atenção com Hiperatividade - psicologia
Termos MeSH relevantes adicionais
- Transtornos Mentais, Desordem Mental
- Distúrbios induzidos quimicamente
- Processos Patológicos
- Doenças do Sistema Nervoso
- Manifestações Neurológicas
- Transtornos de Personalidade
- Discinesias
- Transtornos de Déficit de Atenção e Comportamento Disruptivo
- Distúrbios do Neurodesenvolvimento
- Transtornos Relacionados a Substâncias
- Doença
- Transtorno de Déficit de Atenção com Hiperatividade
- Transtorno de personalidade antisocial
- Hipercinesia
Outros números de identificação do estudo
- U01MH050453 (Concessão/Contrato do NIH dos EUA)
- DSIR CT
- MH50447
- MH50454
- MH50461
- MH50467
- MH50440
Essas informações foram obtidas diretamente do site clinicaltrials.gov sem nenhuma alteração. Se você tiver alguma solicitação para alterar, remover ou atualizar os detalhes do seu estudo, entre em contato com register@clinicaltrials.gov. Assim que uma alteração for implementada em clinicaltrials.gov, ela também será atualizada automaticamente em nosso site .
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