Inositoltilskudd for å behandle PCOS (INSUPP-PCOS) (INSUPP-PCOS)
Inositoltilskudd for å behandle polycystisk ovariesyndrom: En dobbelblind dose varierende RCT (INSUPP-PCOS)
To determine if Inositol, a dietary supplement, will improve ovarian and adrenal androgen excess in women with Polycystic Ovarian Syndrome(PCOS).
Studieoversikt
Status
Forhold
Intervensjon / Behandling
Detaljert beskrivelse
This trial will test prospectively the effects of inositol supplementation in a dose ranging double blind randomized controlled trial, according to CONSORT guidelines. This will be a four armed study of three doses of inositol vs. placebo over a three month period with the reduction in hyperandrogenism (based on serum testosterone levels) as the primary outcome and key secondary outcomes of the change in sex hormone binding globulin(SHBG) and the related free androgen index, fasting insulin levels and area under the curve glucose levels from an oral glucose challenge test (OGTT). The hypothesis is that women with PCOS who receive inositol supplementation will have a dose related reduction in hyperandrogenism. Further, we propose that the primary mechanism of inositol will be a significant improvement in hyperandrogenism (both ovarian and adrenal) vs. placebo, as documented by a lower free androgen index [decreased total testosterone and increased sex hormone blinding globulin (SHBG)], lower sebum measures and lower antral follicle counts of the ovary and anti-Mullerian hormone, all of which will correlate with the decrease in hyperandrogenism.
Studietype
Registrering (Faktiske)
Fase
- Fase 2
Kontakter og plasseringer
Studiesteder
-
-
Pennsylvania
-
Hershey, Pennsylvania, Forente stater, 17033
- Penn State College of Medicine, Penn State Milton S. Hershey Medical Center
-
Philadelphia, Pennsylvania, Forente stater, 19104
- University of Pennsylvania
-
-
Deltakelseskriterier
Kvalifikasjonskriterier
Alder som er kvalifisert for studier
Tar imot friske frivillige
Kjønn som er kvalifisert for studier
Beskrivelse
Inclusion Criteria:
- Women with chronic anovulation or oligomenorrhea defined as spontaneous intermenstrual periods of greater than or equal to 45 days or a total of less than or equal to 8 menses per year.
- Women with Hyperandrogenism defined as a total testosterone greater than 50 ng/dL or a free androgen index greater than 10.
- Women with Polycystic Ovaries on Ultrasound defined as either 12 or more follicles measuring 2-9 mm in diameter or increased ovarian volume greater than 10 cm.
Exclusion Criteria:
- Women with Hyperprolactinemia defined as 2 prolactin levels at least one week apart greater than 30 ng/mL.
- Women with known 21-hydroxylase deficiency or other enzyme deficiency leading to the congenital adrenal hyperplasia.
- Women with elevated FSH levels greater than 10 mIU/mL.
- Women with uncorrected thyroid disease as per ASRM guidelines for nonpregnant subjects (TSH less than 0.45 mIU/mL or greater than 4.5 MIU/mL).
- Women with a suspected adrenal or ovarian tumor secreting androgens
- Women with Cushing's syndrome
- Women on confounding medications which affect ovarian function including metformin, hormonal contraceptives or other medications for type 2 diabetes
- Women with medical conditions that are contraindications to OTC inositol or previous allergic reactions to the supplement or to the placebo maltodextrin or inulin.
Studieplan
Hvordan er studiet utformet?
Designdetaljer
- Primært formål: Behandling
- Tildeling: Randomisert
- Intervensjonsmodell: Parallell tildeling
- Masking: Firemannsrom
Våpen og intervensjoner
Deltakergruppe / Arm |
Intervensjon / Behandling |
|---|---|
|
Placebo komparator: Placebo Treatment bid
Women with PCOS will receive the daily placebo (maltodextrin and inulin) in an identical fashion as the active study group and will be monitored the same. |
Placebo
Andre navn:
|
|
Eksperimentell: Active Treatment with Inositol 1gm/bid
Women with PCOS will receive daily inositol powder BID as active drug (each dose with 1000 mg of myo-inositol and 25 mg of d-chiro-inositol) over the initial 3 mos RCT period. |
1gm/bid, 2gm/bid or 3gm/bid of Inositol powder |
|
Eksperimentell: Active Treatment with Inositol 2 gm/bid
Women with PCOS will receive daily inositol powder BID as active drug (each dose with 2000 mg of myo-inositol and 50 mg of d-chiro-inositol) over the initial 3 mos RCT period. |
1gm/bid, 2gm/bid or 3gm/bid of Inositol powder |
|
Eksperimentell: Active Treatment with Inositol 3 gm/bid
Women with PCOS will receive daily inositol powder BID as active drug (each dose with 3000 mg of myo-inositol and 75 mg of d-chiro-inositol) over the initial 3 mos RCT period. |
1gm/bid, 2gm/bid or 3gm/bid of Inositol powder |
Hva måler studien?
Primære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
Total Testosterone
Tidsramme: 3 months (baseline, 1 month and 3 month visits)
|
Total testosterone levels measured at baseline, 1 month, and 3 month visits. |
3 months (baseline, 1 month and 3 month visits)
|
Sekundære resultatmål
Resultatmål |
Tiltaksbeskrivelse |
Tidsramme |
|---|---|---|
|
SHBG
Tidsramme: 3 months (baseline, 1 month and 3 month visits)
|
Sex hormone-binding globulin (SHBG) levels measured at baseline, 1 month, and 3 month visits. |
3 months (baseline, 1 month and 3 month visits)
|
|
Free Androgen Index (FAI)
Tidsramme: 3 months (baseline, 1 month and 3 month visits)
|
Free Androgen Index calculated at baseline, 1 month, and 3 month visits. FAI is calculated as (testosterone/SHBG)*100 (after converting testosterone to the same units as SHBG) |
3 months (baseline, 1 month and 3 month visits)
|
|
Area Under the Curve (AUC) of Glucose
Tidsramme: 3 months (baseline and 3 month visits)
|
AUC of a 2-hour 75g glucose tolerance test, which measures glucose at 0, 30, 60, 90, and 120 minutes. AUC was calculated at baseline and 3 month visit. |
3 months (baseline and 3 month visits)
|
|
Fasting Insulin
Tidsramme: 3 months (baseline and 3 month visits)
|
Fasting insulin levels measured at baseline and 3 month visit. |
3 months (baseline and 3 month visits)
|
Samarbeidspartnere og etterforskere
Sponsor
Samarbeidspartnere
Etterforskere
- Hovedetterforsker: Richard S. Legro, M.D., Penn State College of Medicine, Hershey Medical Center
Studierekorddatoer
Studer hoveddatoer
Studiestart (Faktiske)
Primær fullføring (Faktiske)
Studiet fullført (Faktiske)
Datoer for studieregistrering
Først innsendt
Først innsendt som oppfylte QC-kriteriene
Først lagt ut (Faktiske)
Oppdateringer av studieposter
Sist oppdatering lagt ut (Faktiske)
Siste oppdatering sendt inn som oppfylte QC-kriteriene
Sist bekreftet
Mer informasjon
Begreper knyttet til denne studien
Nøkkelord
Ytterligere relevante MeSH-vilkår
- Urogenitale sykdommer
- Kjønnssykdommer
- Sykdommer i det endokrine systemet
- Neoplasmer
- Mannlige urogenitale sykdommer
- Kvinnelige urogenitale sykdommer
- Kvinnelige urogenitale sykdommer og graviditetskomplikasjoner
- Metabolske sykdommer
- Kjønnssykdommer, kvinner
- Glukosemetabolismeforstyrrelser
- Sykdommer i eggstokkene
- Adnexal sykdommer
- Gonadal lidelser
- Medfødte abnormiteter
- Hyperinsulinisme
- Cyster på eggstokkene
- Cyster
- Forstyrrelser i kjønnsutvikling
- Urogenitale abnormiteter
- Hyperglykemi
- 46, XX Forstyrrelser i kjønnsutvikling
- Adrenogenital syndrom
- Medfødte, arvelige og neonatale sykdommer og abnormiteter
- Ernæringsmessige og metabolske sykdommer
- Polycystisk ovariesyndrom
- Insulinresistens
- Glukoseintoleranse
- Hyperandrogenisme
- Anovulation
- Organiske kjemikalier
- Kostholdskarbohydrater
- Karbohydrater
- Polymerer
- Makromolekylære stoffer
- Alkoholer
- Polysakkarider
- Stivelse
- Glukaner
- Biopolymerer
- Fruktaner
- Sukkeralkoholer
- Inositol
- maltodextrin
- Inulin
Andre studie-ID-numre
- Study00010252
- 1R01AT009484-01A1 (U.S. NIH-stipend/kontrakt)
Legemiddel- og utstyrsinformasjon, studiedokumenter
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