- ICH GCP
- Register voor klinische proeven in de VS.
- Klinische proef NCT04829864
Supporting the Transition to and Engagement in Parenthood (STEP)
13 juni 2022 bijgewerkt door: Nicolas Berthelot, Université du Québec à Trois-Rivières
Phase 2 of STEP (Supporting the Transition to and Engagement in Parenthood): A Prenatal Intervention for Women Who Experienced Childhood Trauma
STEP (Supporting the Transition to and Engagement in Parenthood) is a manualized group intervention for pregnant women exposed to early life adversity designed to foster emotion regulation and reflective capacities in participants.
Studie Overzicht
Toestand
Actief, niet wervend
Interventie / Behandeling
Studietype
Ingrijpend
Inschrijving (Werkelijk)
110
Fase
- Fase 2
- Fase 1
Contacten en locaties
In dit gedeelte vindt u de contactgegevens van degenen die het onderzoek uitvoeren en informatie over waar dit onderzoek wordt uitgevoerd.
Studie Locaties
-
-
Quebec
-
Québec, Quebec, Canada, G1C3S2
- Centre Intégré Universitaire de Santé et de Services Sociaux de la Capitale-Nationale
-
Trois-Rivières, Quebec, Canada, G6P 6N2
- Centre intégré de santé et de services sociaux de la Mauricie-et-du-Centre-du-Québec
-
-
Deelname Criteria
Onderzoekers zoeken naar mensen die aan een bepaalde beschrijving voldoen, de zogenaamde geschiktheidscriteria. Enkele voorbeelden van deze criteria zijn iemands algemene gezondheidstoestand of eerdere behandelingen.
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
18 jaar en ouder (Volwassen, Oudere volwassene)
Accepteert gezonde vrijwilligers
Ja
Geslachten die in aanmerking komen voor studie
Vrouw
Beschrijving
Inclusion Criteria:
- Pregnant women ages 18+ years
- Interested in reflecting about their experience of pregnancy and willing to attend weekly sessions in group setting.
- Must speak French as their first language
Exclusion Criteria:
- Severe psychiatric disorders (schizophrenia, bipolar disorder)
- Severe emotional dysregulation
- Current self-harm
- Not sure to keep the child
- High level of hostility
Studie plan
Dit gedeelte bevat details van het studieplan, inclusief hoe de studie is opgezet en wat de studie meet.
Hoe is de studie opgezet?
Ontwerpdetails
- Primair doel: Ondersteunende zorg
- Toewijzing: Niet-gerandomiseerd
- Interventioneel model: Parallelle opdracht
- Masker: Geen (open label)
Wapens en interventies
Deelnemersgroep / Arm |
Interventie / Behandeling |
---|---|
Geen tussenkomst: Gebruikelijke prenatale zorg
Deelnemers aan de vergelijkingsgroep krijgen de gebruikelijke prenatale zorg (bijv.
prenatale lessen)
|
|
Experimenteel: STEP
Participants will participate, online or in-person, to the 8-9 sessions of the program addressing the psychological experience of pregnancy and supporting reflective capacities in relation to trauma and motherhood.
|
The program is offered by two facilitators to groups of three to seven women, in-person or online.
The program is divided in three phases entitles "Becoming a mother"; "A look at my own history" and "Looking ahead".
The first phase aims to explore and normalize the emotions experienced by the participants in the course of their pregnancy and to support the use of healthy emotion regulation strategies.
The second phase aims to support mentalization of trauma, by discussing the nature of trauma and its impact; by validating participants' feelings as understandable responses to trauma; by supporting a reflection on positive and harsh experiences with significant others and the ways both types of experiences influenced participants' mental states; and identifying how participants coped with trauma.
In the last phase, discussions focus on participants' needs and strengths, on available resources to support resilience and envision positive and challenging moments with the child.
|
Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
---|---|---|
Perceptie van verandering in domeinen van functioneren tijdens de zwangerschap
Tijdsspanne: Toegediend op één tijdstip, aan het einde van het derde trimester van de zwangerschap. De deelnemer rapporteert over waargenomen veranderingen gedurende de laatste 9 maanden.
|
We hebben een instrument ontwikkeld dat iemands perceptie van verandering (negatieve verandering naar positieve verandering) beoordeelt op meerdere domeinen van functioneren, waaronder de kwaliteit van de relatie met de partner; de kwaliteit van de relatie met belangrijke anderen, zelfrespect; emotieherkenning, -regulatie en -expressie; sociale steun en ouderlijk vertrouwen.
Deze domeinen worden apart beoordeeld.
|
Toegediend op één tijdstip, aan het einde van het derde trimester van de zwangerschap. De deelnemer rapporteert over waargenomen veranderingen gedurende de laatste 9 maanden.
|
Mate van tevredenheid over de interventie
Tijdsspanne: Tevredenheid beoordeeld na elke sessie van het programma en na afloop ervan. De tevredenheid wordt dus beoordeeld tussen het tweede trimester van de zwangerschap en 36 weken zwangerschap, voor een totale periode van maximaal 7 maanden.
|
Deelnemers worden uitgenodigd om na elke sessie en aan het einde van het programma een zelfrapportagevragenlijst in te vullen om hun mate van tevredenheid te beoordelen, met behulp van een Likert-schaal.
Aan het einde van het programma wordt ook een semigestructureerd interview afgenomen dat kwalitatieve informatie zal verschaffen over hun waardering voor het programma.
|
Tevredenheid beoordeeld na elke sessie van het programma en na afloop ervan. De tevredenheid wordt dus beoordeeld tussen het tweede trimester van de zwangerschap en 36 weken zwangerschap, voor een totale periode van maximaal 7 maanden.
|
Change in psychological distress from baseline (2nd trimester of pregnancy) to the end of the third trimester of pregnancy (around 36 weeks) and from baseline to 6-months postpartum
Tijdsspanne: Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Participants are invited to complete a self-report questionnaire (Kessler Distress Scale) assessing psychological distress.
Change between baseline and end of pregnancy will be assessed, as well as between baseline and 6-month postpartum,
|
Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Prenatal reflective functioning
Tijdsspanne: Administered at one time-point, at the end of the third trimester of pregnancy. The measure will assess current level of reflective functions.
|
Participants will complete the Pregnancy Interview at the end of the third trimester of pregnancy.
The interview will be subsequently coded for prenatal reflective functioning.
Scores in participants to the intervention will be compared to scores of matched controls who did not participate to the intervention.
|
Administered at one time-point, at the end of the third trimester of pregnancy. The measure will assess current level of reflective functions.
|
Parental reflective functioning
Tijdsspanne: Administered at one time-point, at 6-moths postpartum. The measure will assess current level of reflective functions.
|
Participants will complete the Parental Reflective Functioning Questionnaire at 6 months postpartum.
Scores in participants to the intervention will be compared to scores of matched controls who did not participate to the intervention.
|
Administered at one time-point, at 6-moths postpartum. The measure will assess current level of reflective functions.
|
Change in trauma-specific reflective functioning
Tijdsspanne: Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
The Failure to mentalize trauma questionnaire (FMTQ) will be administered at baseline, at the end of the third trimester of pregnancy and at 6-months postpartum.
Change between time-points will be assessed.
|
Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Change in trauma-specific reflective functioning
Tijdsspanne: Administered at one time-point, at 6-moths postpartum. The measure will assess current level of reflective functions.
|
Participants will participate to the Trauma Meaning Making Interview (TMMI) at 6-months postnatal.
The interview will be subsequently coded for trauma-specific reflective functioning.
Scores in participants to the intervention will be compared to scores of matched controls who did not participate to the intervention.
|
Administered at one time-point, at 6-moths postpartum. The measure will assess current level of reflective functions.
|
Secundaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
---|---|---|
Verandering in perceptie van ouderlijke competentie
Tijdsspanne: Gegevens worden verzameld bij rekrutering (2e trimester van de zwangerschap) en bij 36 weken zwangerschap. De beoordelingstermijn beslaat daarmee een periode van 7 maanden.
|
Deelnemers worden uitgenodigd om een zelfrapportagevragenlijst over moedervertrouwen in te vullen (Vragenlijst moedervertrouwen).
Verandering tussen baseline en het einde van de zwangerschap zal worden beoordeeld.
|
Gegevens worden verzameld bij rekrutering (2e trimester van de zwangerschap) en bij 36 weken zwangerschap. De beoordelingstermijn beslaat daarmee een periode van 7 maanden.
|
Change in post-traumatic stress symptoms from baseline (2nd trimester of pregnancy) to the end of the third trimester of pregnancy (around 36 weeks) and from baseline to 6-months postpartum
Tijdsspanne: Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Participants are invited to complete a self-report questionnaire of PTSD symptoms (Post-traumatic checklist for DSM-5).
Change between baseline and the end of pregnancy will be assessed as well as between baseline and 6-months postpartum
|
Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Change in anger from baseline (2nd trimester of pregnancy) to the end of the third trimester of pregnancy (around 36 weeks) and from baseline to 6-months postpartum
Tijdsspanne: Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Participants are invited to complete a self-report questionnaire of anger states (STAXI).
Change between baseline and the end of pregnancy will be assessed as well as between baseline and 6-months postpartum
|
Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Change in antenatal attachment
Tijdsspanne: Data will be collected at recruitment (2nd trimester of pregnancy) and at 36-weeks of pregnancy. he assessment time frame thus covers a period of 7 months.
|
Participants are invited to complete a self-report questionnaire of antenatal attachment (Maternal antenatal attachment scale).
Change between baseline and the end of pregnancy will be assessed.
|
Data will be collected at recruitment (2nd trimester of pregnancy) and at 36-weeks of pregnancy. he assessment time frame thus covers a period of 7 months.
|
Self-compassion
Tijdsspanne: Administered at one time-point, at the end of the third trimester of pregnancy. The measure will assess current level of self-compassion.
|
Participants are invited to complete a self-report questionnaire of self-compassion at the end of the third trimester of pregnancy.
Scores in participants to the intervention will be compared to scores of matched controls who did not participate to the intervention.
|
Administered at one time-point, at the end of the third trimester of pregnancy. The measure will assess current level of self-compassion.
|
Connection to care
Tijdsspanne: From the third trimester of pregnancy to 6 months postpartum. The assessment time frame thus covers a period of 7 months.
|
Participants will be referred to community agencies for resources based on need during their participation to STEP.
Their utilization of other resources will be assessed using self-reported questionnaires at the end of the third trimester of pregnancy and at 6 months postpartum
|
From the third trimester of pregnancy to 6 months postpartum. The assessment time frame thus covers a period of 7 months.
|
Change in emotion regulation strategies
Tijdsspanne: Data will be collected at recruitment (2nd trimester of pregnancy) and at 36-weeks of pregnancy. he assessment time frame thus covers a period of 7 months.
|
Participants are invited to complete a self-report questionnaire of emotion regulation strategies (CERQ).
Change between baseline and the end of pregnancy, as well as between baseline and 6 months postpartum will be assessed.
|
Data will be collected at recruitment (2nd trimester of pregnancy) and at 36-weeks of pregnancy. he assessment time frame thus covers a period of 7 months.
|
Post-traumatic growth
Tijdsspanne: Administered at one time-point, at the end of the third trimester of pregnancy. The measure will assess current level of post-traumatic growth.
|
Participants are invited to complete a self-report questionnaire of post-traumatic growth at the end of the third trimester of pregnancy.
Scores in participants to the intervention will be compared to scores of matched controls who did not participate to the intervention.
|
Administered at one time-point, at the end of the third trimester of pregnancy. The measure will assess current level of post-traumatic growth.
|
Parental stress
Tijdsspanne: Administered at one time-point, at the 6-months postpartum assessment. The measure will assess current level of parental stress.
|
Participants are invited to complete a self-report questionnaire of parental stress at 6-months postpartum.
Scores in participants to the intervention will be compared to scores of matched controls who did not participate to the intervention.
|
Administered at one time-point, at the 6-months postpartum assessment. The measure will assess current level of parental stress.
|
Maternal bonding
Tijdsspanne: Administered at one time-point, at the 6-months postpartum assessment. The measure will assess current level of maternal bonding.
|
Participants are invited to complete a self-report questionnaire of maternal bonding at 6-months postpartum.
Scores in participants to the intervention will be compared to scores of matched controls who did not participate to the intervention.
|
Administered at one time-point, at the 6-months postpartum assessment. The measure will assess current level of maternal bonding.
|
Maternal competence
Tijdsspanne: Administered at one time-point, at the 6-months postpartum assessment. The measure will assess current level of perceived maternal competence..
|
Participants are invited to complete a self-report questionnaire of maternal sense of competence at 6-months postpartum.
Scores in participants to the intervention will be compared to scores of matched controls who did not participate to the intervention.
|
Administered at one time-point, at the 6-months postpartum assessment. The measure will assess current level of perceived maternal competence..
|
Depression
Tijdsspanne: Data will be collected at 36-weeks of pregnancy and at 6-months postpartum. The assessment time frame thus covers a period of 7 months.
|
Participants are invited to complete a self-report questionnaire of post-partum depression at the end of the third trimester of pregnancy and at 6-months postpartum.
Scores in participants to the intervention will be compared to scores of matched controls who did not participate to the intervention separately for each time point.
|
Data will be collected at 36-weeks of pregnancy and at 6-months postpartum. The assessment time frame thus covers a period of 7 months.
|
Maternal behaviors
Tijdsspanne: Administered at one time-point, around 12-months postpartum. The measure will assess current maternal behaviors..
|
Mother-infant interactions will be realized and videotaped for subsequent coding of maternal behaviors around 12-months postpartum.
Scores in participants to the intervention will be compared to scores of matched controls who did not participate to the intervention
|
Administered at one time-point, around 12-months postpartum. The measure will assess current maternal behaviors..
|
Change in affective states from baseline (2nd trimester of pregnancy) to the end of the third trimester of pregnancy (around 36 weeks) and from baseline to 6-months postpartum
Tijdsspanne: Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Participants are invited to complete a self-report questionnaire (Positive and Negative Affect Scale) assessing positive and negative affects.
Change between baseline and end of pregnancy will be assessed as well as between baseline and 6-month postpartum,
|
Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Infant general development
Tijdsspanne: Administered at one time-point, at 6-moths postpartum. The measure will assess current level of infant development.
|
The ASQ-3 will be administered at 6-months postnatal to assess infant development.
|
Administered at one time-point, at 6-moths postpartum. The measure will assess current level of infant development.
|
Infant socio-emotional development
Tijdsspanne: Administered at one time-point, at 6-moths postpartum. The measure will assess current level of infant development.
|
The ASQ-SE will be administered at 6-months postnatal to assess infant socio-emotional development.
|
Administered at one time-point, at 6-moths postpartum. The measure will assess current level of infant development.
|
Infant temperament
Tijdsspanne: Administered at one time-point, at 6-moths postpartum.The measure will assess current infant temperament
|
The IBQ will be administered at 6-months postnatal to assess infant temperament
|
Administered at one time-point, at 6-moths postpartum.The measure will assess current infant temperament
|
Andere uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
---|---|---|
Change in Inflammation
Tijdsspanne: Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Inflammation will be assessed using blood samples at baseline, at the end of the third trimester of pregnancy and around 6 months postpartum.
Change between baseline and the end of pregnancy, as well as between baseline and 6 months postpartum will be assessed.
|
Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Change in cortisol
Tijdsspanne: Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Systemic cortisol will be assessed using blood samples at baseline, at the end of the third trimester of pregnancy and around 6 months postpartum.
Change between baseline and the end of pregnancy, as well as between baseline and 6 months postpartum will be assessed.
|
Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Personality dysfunctions
Tijdsspanne: Administered at one time-point, at the second trimester of pregnancy. The measure will assess current level of personality dysfunctions.
|
Personality dysfunctions are assessed at baseline and will be considered as a moderator of the intervention effectiveness.
Personality dysfunctions will be measured using the Self and Interpersonal Functioning Rating Scale, a 24-item self-report questionnaire designed to assess the four core elements of personality pathology (Identity, Self-direction, Empathy, and Intimacy) from the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Level of Personality Functioning for personality disorders
|
Administered at one time-point, at the second trimester of pregnancy. The measure will assess current level of personality dysfunctions.
|
Change in intimate partner violence
Tijdsspanne: Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Participants are invited to complete a self-report questionnaire of intimate partner violence.
Change between baseline and 6 months postpartum will be assessed.
|
Data will be collected at recruitment (2nd trimester of pregnancy), at 36-weeks of pregnancy and at 6-months postnatal. The assessment time frame thus covers a period of 13 months.
|
Medewerkers en onderzoekers
Hier vindt u mensen en organisaties die betrokken zijn bij dit onderzoek.
Publicaties en nuttige links
De persoon die verantwoordelijk is voor het invoeren van informatie over het onderzoek stelt deze publicaties vrijwillig ter beschikking. Dit kan gaan over alles wat met het onderzoek te maken heeft.
Nuttige links
Studie record data
Deze datums volgen de voortgang van het onderzoeksdossier en de samenvatting van de ingediende resultaten bij ClinicalTrials.gov. Studieverslagen en gerapporteerde resultaten worden beoordeeld door de National Library of Medicine (NLM) om er zeker van te zijn dat ze voldoen aan specifieke kwaliteitscontrolenormen voordat ze op de openbare website worden geplaatst.
Bestudeer belangrijke data
Studie start (Werkelijk)
15 juni 2018
Primaire voltooiing (Werkelijk)
15 maart 2022
Studie voltooiing (Verwacht)
15 mei 2023
Studieregistratiedata
Eerst ingediend
4 maart 2021
Eerst ingediend dat voldeed aan de QC-criteria
31 maart 2021
Eerst geplaatst (Werkelijk)
2 april 2021
Updates van studierecords
Laatste update geplaatst (Werkelijk)
14 juni 2022
Laatste update ingediend die voldeed aan QC-criteria
13 juni 2022
Laatst geverifieerd
1 juni 2022
Meer informatie
Termen gerelateerd aan deze studie
Trefwoorden
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- STEP Phase 2
Plan Individuele Deelnemersgegevens (IPD)
Bent u van plan om gegevens van individuele deelnemers (IPD) te delen?
NEE
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Nee
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
Nee
Deze informatie is zonder wijzigingen rechtstreeks van de website clinicaltrials.gov gehaald. Als u verzoeken heeft om uw onderzoeksgegevens te wijzigen, te verwijderen of bij te werken, neem dan contact op met register@clinicaltrials.gov. Zodra er een wijziging wordt doorgevoerd op clinicaltrials.gov, wordt deze ook automatisch bijgewerkt op onze website .
Klinische onderzoeken op Geestelijke gezondheidskwestie
-
South West Yorkshire Partnership NHS Foundation...OnbekendRedenen voor detentie op grond van de Mental Health Act 1983Verenigd Koninkrijk
-
Yonsei UniversityVoltooidVerpleegkundigen die werken bij het Community Mental Health Welfare CenterKorea, republiek van
-
University of Dublin, Trinity CollegeOnbekendBrain Health Gepensioneerde topsporters
-
Lady Hardinge Medical CollegeVoltooidKennis Maternal-Child Health Services
-
University of Colorado, DenverEunice Kennedy Shriver National Institute of Child Health and Human Development... en andere medewerkersActief, niet wervendPreventieve gezondheidsdiensten (PREV HEALTH SERV)Verenigde Staten
-
The Hospital for Sick ChildrenBill and Melinda Gates Foundation; Aga Khan UniversityActief, niet wervendUnder Five Child Health Voeding en immunisatiePakistan
-
Queens College, The City University of New YorkWervingPublicatie van artikelen ingediend bij het American Journal of Public HealthVerenigde Staten
-
Kliniek ViaSanaSt. Anna Ziekenhuis, Geldrop, NetherlandsVoltooidPijn | Opioïde gebruik | Totale knievervanging | E-health-appNederland
-
Istanbul University - Cerrahpasa (IUC)WervingHartchirurgie, Hartchirurgie, Ontslagonderwijs, Verpleging, Televerpleging, m-Health, Kwaliteit van Leven, HerstelKalkoen
-
University of California, DavisVoltooidFunctioneel ouder worden | Subjectieve cognitieve zorgen | Compensatiestrategieën | Brain Health-activiteitenVerenigde Staten
Klinische onderzoeken op STEP
-
The AlfredMonash UniversityWervingFibrose | Longziekten | Alvleesklier Ziekten | Taaislijmziekte | Genetische ziekten | AdemhalingsziektenAustralië
-
Menoufia UniversityVoltooidKeizersnede | Wond openspringen
-
Dana-Farber Cancer InstituteNational Cancer Institute (NCI)WervingKanker | Slapeloosheid | Slapeloosheid als gevolg van een medische aandoeningVerenigde Staten
-
University of Wisconsin, MilwaukeeMedical College of Wisconsin; Children's Hospital and Health System Foundation... en andere medewerkersVoltooidJongvolwassene, Kanker, Lichamelijke activiteitVerenigde Staten
-
University of ManitobaVictoria General Hospital Foundation; Reh-Fit Fitness Centre; Wellness Institute-Seven...IngetrokkenHart-en vaatziekten
-
The Hong Kong Polytechnic UniversityUniversity Grants Committee, Hong KongActief, niet wervend
-
Université du Québec à Trois-RivièresPublic Health Agency of Canada (PHAC); Canada Research Chairs Endowment of the...Actief, niet wervendCovid-19-pandemie | Psychologisch | Geestelijke gezondheidskwestie | Moederlijke nood | Prenatale stressCanada
-
University of Alabama at BirminghamNational Institute of Mental Health (NIMH)IngetrokkenHiv/aids | Stoornissen in het gebruik van middelen | Geestelijke gezondheidskwestieVerenigde Staten
-
Parkinson's Disease Research, Education, and Clinical...VoltooidZiekte van ParkinsonVerenigde Staten
-
The University of Texas Health Science Center,...Georgetown UniversityBeëindigdBeroerte Preventie | Verlaging van de bloeddrukVerenigde Staten