Clinical Trials: SEARCH[STUDY] TILT[STUDY:STUDY-FIRST-POSTED] ( Critical Limb Ischemia [STUDY:DISEASE] )
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NCTID/Status
Study
Last Changed
101
NCT03175744
Recruiting
Recruiting
Stellarex DCB Versus Standard Balloon Angioplasty for Treatment of Below-The-Knee (BTK) Arteries
Conditions: Critical Limb Ischemia
Intervention: Stellarex DCB, PTA Catheter
Conditions: Critical Limb Ischemia
Intervention: Stellarex DCB, PTA Catheter
April 16, 2019
102
NCT02044666
Completed
Completed
Cook Micronized Small Intestinal Submucosa (SIS) for Critical Limb Ischemia
Conditions: Ischemia; Peripheral Arterial Disease; Peripheral Vascular Diseases
Intervention: Micronized Small Intestinal Submucosa (SIS)
Conditions: Ischemia; Peripheral Arterial Disease; Peripheral Vascular Diseases
Intervention: Micronized Small Intestinal Submucosa (SIS)
January 5, 2017
103
NCT02802852
Unknown status
Unknown status
Proteomics and Stem Cell Therapy as a New Vascularization Strategy
Conditions: Critical Limb Ischemia
Intervention: Pneumatic Calf Compression, Filgrastim
Conditions: Critical Limb Ischemia
Intervention: Pneumatic Calf Compression, Filgrastim
June 13, 2016
104
NCT02054416
Unknown status
Unknown status
External Compression Therapy for Secondary Prevention of Lower-Limb Loss and Cardiovascular Mortality
Conditions: Critical Limb Ischemia
Intervention: ArtAssist© Device
Conditions: Critical Limb Ischemia
Intervention: ArtAssist© Device
November 4, 2016
105
NCT02043795
Unknown status
Unknown status
Drug Impregnated Bioabsorbable Stent in Asian Population Extremity Arterial Revascularization (DISAPEAR Study)
Conditions: Critical Limb Ischemia
Intervention: BVS, Abbott Vascular
Conditions: Critical Limb Ischemia
Intervention: BVS, Abbott Vascular
July 19, 2017
106
NCT01870401
Active, not recruiting
Active, not recruiting
Lutonix DCB Versus Standard Balloon Angioplasty for Treatment of Below-The-Knee (BTK) Arteries
Conditions: Critical Limb Ischemia
Intervention: Lutonix DCB, Uncoated PTA Catheter
Conditions: Critical Limb Ischemia
Intervention: Lutonix DCB, Uncoated PTA Catheter
July 31, 2019
107
NCT01273740
Completed
Completed
January 7, 2011
108
NCT01584986
Completed
Completed
Autologous Angiogenic Cell Precursors (ACPs) for the Treatment of Peripheral Artery Disease
Conditions: Critical Limb Ischemia
Intervention: ACP Injections
Conditions: Critical Limb Ischemia
Intervention: ACP Injections
April 24, 2012
109
NCT01285986
Completed
Completed
Scandinavian Miller Collar Study
Conditions: Critical Limb Ischemia
Intervention: Vein Collar At The Distal Anastomosis
Conditions: Critical Limb Ischemia
Intervention: Vein Collar At The Distal Anastomosis
January 27, 2011
110
NCT02287974
Terminated
Terminated
Clinical Trial I/II Opened, Randomized and Controlled for the Study of the Use of Stem Cells Therapy in Insulinized Diabetic Patients Type 2 With Critical Ischemia in Lower Limbs (CLI): Study of the Needs of Insulin
Conditions: Critical Limb Ischemia (CLI)
Intervention: Stem Cell Infusion
Conditions: Critical Limb Ischemia (CLI)
Intervention: Stem Cell Infusion
December 17, 2018
111
NCT00498069
Completed
Completed
Study of Autologous Bone Marrow Concentrate for the Treatment of Critical Limb Ischemia (CLI)
Conditions: Ischemia
Intervention: Harvest Smartprep2 BMAC System, SmartPReP2 BMAC System, Placebo
Conditions: Ischemia
Intervention: Harvest Smartprep2 BMAC System, SmartPReP2 BMAC System, Placebo
March 17, 2015
112
NCT03712644
Recruiting
Recruiting
Coronary Revascularization Versus Conservative Therapy in Patients With Treated Critical Limb Ischemia
Conditions: Obstructive Coronary Artery Disease
Intervention: FFR-guided Coronary Revascularization
Conditions: Obstructive Coronary Artery Disease
Intervention: FFR-guided Coronary Revascularization
November 3, 2018
113
NCT00392509
Completed
Completed
ALD-301 for Critical Limb Ischemia, Randomized Trial
Conditions: Critical Limb Ischemia; Peripheral Arterial Disease; Peripheral Vascular Disease
Intervention: ALDH-br Bone Marrow Cells Vs. Mononuclear Bone Marrow Cells
Conditions: Critical Limb Ischemia; Peripheral Arterial Disease; Peripheral Vascular Disease
Intervention: ALDH-br Bone Marrow Cells Vs. Mononuclear Bone Marrow Cells
May 13, 2009
114
NCT00189540
Completed
Completed
Study of Hepatocyte Growth Factor (HGF) Via Plasmid Vector to Improve Perfusion in Critical Limb Ischemia Patients With Peripheral Ischemic Ulcers
Conditions: Arterial Occlusive Disease; Peripheral Vascular Disease; Ischemia; Ulcers
Intervention: HGF Plasmid, Placebo
Conditions: Arterial Occlusive Disease; Peripheral Vascular Disease; Ischemia; Ulcers
Intervention: HGF Plasmid, Placebo
September 14, 2017
115
NCT01548378
Completed
Completed
Safety and Efficacy Study Using Gene Therapy for Critical Limb Ischemia
Conditions: Arterial Occlusive Disease; Ulcers; Ischemia; Peripheral Vascular Disease
Intervention: NL003, NL003, NL003, Normal Saline
Conditions: Arterial Occlusive Disease; Ulcers; Ischemia; Peripheral Vascular Disease
Intervention: NL003, NL003, NL003, Normal Saline
September 10, 2018
116
NCT01173094
Unknown status
Unknown status
Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part II) (DCLI-II)
Conditions: Vascular Diseases; Diabetes
Intervention: Percutaneous Transluminal Angioplasty, Below-knee Arterial Bypass
Conditions: Vascular Diseases; Diabetes
Intervention: Percutaneous Transluminal Angioplasty, Below-knee Arterial Bypass
December 20, 2012
117
NCT00304837
Completed
Completed
VEGF Gene Transfer for Critical Limb Ischemia
Conditions: Critical Limb Ischemia; Ischemia; Leg Ulcer
Intervention: PVGI.1 (VEGF-2)
Conditions: Critical Limb Ischemia; Ischemia; Leg Ulcer
Intervention: PVGI.1 (VEGF-2)
October 18, 2010
118
NCT00922389
Unknown status
Unknown status
A Clinical Trial on Diabetic Foot Using Peripheral Blood Derived Stem Cells for Treating Critical Limb Ischemia
Conditions: Diabetic Foot; Critical Limb Ischemia; Leg Ulcers
Intervention: Will Receive G-CSF And Peripheral Blood Derived Mononuclear Cells, G-CSF, Standard Therapy
Conditions: Diabetic Foot; Critical Limb Ischemia; Leg Ulcers
Intervention: Will Receive G-CSF And Peripheral Blood Derived Mononuclear Cells, G-CSF, Standard Therapy
June 16, 2009
119
NCT02637492
Recruiting
Recruiting
Development and Validation of a Clinical Prediction Rule for Lower Limb Critical Limb Ischaemia (PREDICCMI)
Conditions: Lower Limb Ischaemia
Intervention: Collection Of Clinical Signs And Symptoms
Conditions: Lower Limb Ischaemia
Intervention: Collection Of Clinical Signs And Symptoms
May 20, 2019
120
NCT01458041
Completed
Completed
Iloprost Therapy in Patients With Critical Limb Ischemia
Conditions: Peripheral Arterial Disease
Intervention: Iloprost (Ilomedin, BAYQ6256)
Conditions: Peripheral Arterial Disease
Intervention: Iloprost (Ilomedin, BAYQ6256)
February 27, 2015
121
NCT02646150
Recruiting
Recruiting
Clinical Use of Magnetic Resonance Perfusion Imaging to Qualitatively Assess Adequate Distal Perfusion After Endovascular Revascularization in Critical Limb Ischemia
Conditions: Lower Limb; Ischemia; Perfusion
Intervention: Magnetic Resonance Perfusion Imaging
Conditions: Lower Limb; Ischemia; Perfusion
Intervention: Magnetic Resonance Perfusion Imaging
September 5, 2018
122
NCT00566657
Completed
Completed
Efficacy and Safety of XRP0038/NV1FGF in Critical Limb Ischemia Patients With Skin Lesions
Conditions: Peripheral Vascular Diseases
Intervention: Riferminogene Pecaplasmid, Placebo (for Riferminogene Pecaplasmid)
Conditions: Peripheral Vascular Diseases
Intervention: Riferminogene Pecaplasmid, Placebo (for Riferminogene Pecaplasmid)
March 30, 2016
123
NCT01171703
Unknown status
Unknown status
Optimized Strategy for Diabetic Patients With Critical Limb Ischemia(Part I)
Conditions: Vascular Diseases; Diabetes
Intervention: Femoral-popliteal Bypass, Stent
Conditions: Vascular Diseases; Diabetes
Intervention: Femoral-popliteal Bypass, Stent
December 20, 2012
124
NCT00067041
Terminated
Terminated
Effects of Remodulin in Patients With Critical Limb Ischemia Following a Vein Bypass Graft
Conditions: Peripheral Vascular Disease
Intervention: Remodulin (treprostinil Sodium) Injection
Conditions: Peripheral Vascular Disease
Intervention: Remodulin (treprostinil Sodium) Injection
March 5, 2013
125
NCT00941733
Completed
Completed
Study of IN.PACT Amphirion™ Drug Eluting Balloon vs. Standard PTA for the Treatment of Below the Knee Critical Limb Ischemia
Conditions: Critical Lower Limb Ischemia
Intervention: IN.PACT Amphirion, Standard PTA
Conditions: Critical Lower Limb Ischemia
Intervention: IN.PACT Amphirion, Standard PTA
January 31, 2018
126
NCT03056742
Withdrawn
Withdrawn
A Clinical Trial to Study the Efficacy and Safety of Stempeucel® in Patients With CLI Due to Buergers Disease
Conditions: Critical Limb Ischemia Due to Buerger's Disease
Intervention: Stempeucel(R)
Conditions: Critical Limb Ischemia Due to Buerger's Disease
Intervention: Stempeucel(R)
April 5, 2017
127
NCT04043078
Recruiting
Recruiting
Exercise In Critical Limb Ischaemia Patients Having Surgery Proof of Concept
Conditions: Patients With CLI; Peri-operative Exercise
Intervention: Exercise
Conditions: Patients With CLI; Peri-operative Exercise
Intervention: Exercise
August 1, 2019
128
NCT01233141
Unknown status
Unknown status
Viennese Registry on Patients With Chronic Critical Limb Ischemia
Conditions: Chronic (> 2 Weeks) Critical Ischemia With Skin Defect in Lower Limbs
Conditions: Chronic (> 2 Weeks) Critical Ischemia With Skin Defect in Lower Limbs
July 27, 2011
129
NCT00913900
Terminated
Terminated
Safety Study of Adult Stem Cells to Treat Patients With Severe Leg Artery Disease
Conditions: Critical Limb Ischemia; Arterial Occlusive Disease; Vascular Diseases
Intervention: Autologous CD133+ Cells
Conditions: Critical Limb Ischemia; Arterial Occlusive Disease; Vascular Diseases
Intervention: Autologous CD133+ Cells
December 4, 2014
130
NCT00224328
Terminated
Terminated
Measurement of Tissue Oxygen Saturation in Chronic Critical Limb Ischemia
Conditions: Peripheral Arterial Disease
Intervention: ODISsey Tissue Oximeter
Conditions: Peripheral Arterial Disease
Intervention: ODISsey Tissue Oximeter
September 11, 2007
131
NCT00633659
Completed
Completed
Pilot Study of Hemospan® in Patients With Chronic Critical Limb Ischemia
Conditions: Vascular Disease; Critical Lower Limb Ischemia
Intervention: Hemospan (MP4OX), Voluven (HES 130/0.4)
Conditions: Vascular Disease; Critical Lower Limb Ischemia
Intervention: Hemospan (MP4OX), Voluven (HES 130/0.4)
August 15, 2013
132
NCT01818310
Active, not recruiting
Active, not recruiting
Safety and Efficacy Study of Autologous Bone Marrow Aspirate Concentrate for No-Option Critical Limb Ischemia
Conditions: Critical Lower Limb Ischemia; Type-2 Diabetes Mellitus
Intervention: Group A: Intramuscular, Group B: Intraarterial, Group C: Intravenous, Group D: Surgical Endovascular Treatment With Maximum Medicamentous Treatment
Conditions: Critical Lower Limb Ischemia; Type-2 Diabetes Mellitus
Intervention: Group A: Intramuscular, Group B: Intraarterial, Group C: Intravenous, Group D: Surgical Endovascular Treatment With Maximum Medicamentous Treatment
March 22, 2018
133
NCT02834143
Completed
Completed
Evaluation of Diagnostic Criteria for Chronic Critical Limb Ischemia
Conditions: Stroke
Intervention: No Intervention
Conditions: Stroke
Intervention: No Intervention
February 21, 2017
134
NCT00515346
Completed
Completed
Study to Evaluate the Safety & Performance of the Xpert(TM) Stent in Treating Below-the-knee Lesions in Patients Undergoing Percutaneous Intervention for Chronic CLI.
Conditions: Chronic Critical Limb Ischemia; Peripheral Vascular Diseases
Intervention: Xpert(TM) Self-expanding Transhepatic Biliary Stent System Feasibility In Treating Chronic Critical Limb Ischemia
Conditions: Chronic Critical Limb Ischemia; Peripheral Vascular Diseases
Intervention: Xpert(TM) Self-expanding Transhepatic Biliary Stent System Feasibility In Treating Chronic Critical Limb Ischemia
December 16, 2013
135
NCT00468000
Completed
Completed
Use of Ixmyelocel-T (Formerly Vascular Repair Cells [VRC]) in Patients With Peripheral Arterial Disease to Treat Critical Limb Ischemia
Conditions: Peripheral Arterial Disease
Intervention: Ixmyelocel-T, Placebo
Conditions: Peripheral Arterial Disease
Intervention: Ixmyelocel-T, Placebo
May 9, 2019
136
NCT00504088
Terminated
Terminated
Plaque Removal Versus Open Bypass Surgery For Critical Limb Ischemia
Conditions: Peripheral Vascular Diseases
Intervention: Bypass, Silverhawk Plaque Excision
Conditions: Peripheral Vascular Diseases
Intervention: Bypass, Silverhawk Plaque Excision
August 19, 2008
137
NCT02820467
Unknown status
Unknown status
Use of Indocyanine Green Angiography in Critical Limb Ischemia
Conditions: Peripheral Arterial Disease
Intervention: Fluorescence Angiography
Conditions: Peripheral Arterial Disease
Intervention: Fluorescence Angiography
March 16, 2017
138
NCT00471289
Active, not recruiting
Active, not recruiting
PTA and Drug Eluting Stents for Infrapopliteal Lesions in Critical Limb Ischemia
Conditions: Peripheral Vascular Disease
Intervention: PTA With Placement Of Paclitaxel-eluting Stent, PTA
Conditions: Peripheral Vascular Disease
Intervention: PTA With Placement Of Paclitaxel-eluting Stent, PTA
May 23, 2014
139
NCT03002116
Completed
Completed
Microwave Radiometry Thermometry for the Diagnosis of Critical Limb Ischemia in Diabetic Patients
Conditions: Diabetic Foot; Peripheral Arterial Disease; Ischaemic Neuropathy
Intervention: Tissue Thermometry Using Non-invasive Microwave Radiometry Device
Conditions: Diabetic Foot; Peripheral Arterial Disease; Ischaemic Neuropathy
Intervention: Tissue Thermometry Using Non-invasive Microwave Radiometry Device
December 22, 2016
140
NCT02750605
Recruiting
Recruiting
DEB ( Drug Eluting Balloon) in Crural Arteries and Critical Limb Ischemia
Conditions: Peripheral Vascular Diseases
Intervention: DEB, POBA
Conditions: Peripheral Vascular Diseases
Intervention: DEB, POBA
November 10, 2018
141
NCT02230527
Recruiting
Recruiting
Establishing the Microcirculatory Effects of Ticagrelor on Tissue Perfusion in Critical Limb Ischemia
Conditions: Peripheral Arterial Disease
Intervention: Ticagrelor, Clopidogrel
Conditions: Peripheral Arterial Disease
Intervention: Ticagrelor, Clopidogrel
January 7, 2019
142
NCT02625740
Completed
Completed
Ultrasound to Enhance Paclitaxel Uptake in Critical Limb Ischemia: the PACUS Trial
Conditions: Peripheral Arterial Disease, Angioplasty
Intervention: Local Exposition Of Target Lesion To High Intensity, Low-frequency Ultrasound, Drug Eluting Ballon Angioplasty, Flow Occlusion With An Angioplasty Balloon, Local Paclitaxel Infusion, Angiographic Control
Conditions: Peripheral Arterial Disease, Angioplasty
Intervention: Local Exposition Of Target Lesion To High Intensity, Low-frequency Ultrasound, Drug Eluting Ballon Angioplasty, Flow Occlusion With An Angioplasty Balloon, Local Paclitaxel Infusion, Angiographic Control
December 8, 2015
143
NCT02129634
Completed
Completed
Singapore INfra-Genicular Angioplasty With PAclitaxel-eluting Balloon for Critical Limb Ischaemia (SINGA-PACLI) Trial
Conditions: Peripheral Arterial Disease
Intervention: CB-PTA, DEB-PTA
Conditions: Peripheral Arterial Disease
Intervention: CB-PTA, DEB-PTA
August 19, 2019
144
NCT00987363
Completed
Completed
Intraarterial Infusion of Autologous Bone Marrow in Diabetic Patients With Chronic Ischemia of Lower Limbs (CLI) no Revascularization
Conditions: Critical Limb Ischemia (CLI); Diabetic Foot
Intervention: Intraarterial Infusion Of Autologous Bone Marrow Cells
Conditions: Critical Limb Ischemia (CLI); Diabetic Foot
Intervention: Intraarterial Infusion Of Autologous Bone Marrow Cells
March 15, 2016
145
NCT02089828
Unknown status
Unknown status
Purified CD34+ Cells Versus Peripheral Blood Mononuclear Cells in Treatment of Critical Limb Ischemia
Conditions: Thromboangiitis Obliterans; Arteritis; Peripheral Arterial Disease
Intervention: Autologous Purified CD34+ Cells, Autologous Peripheral Blood Mononuclear Cells
Conditions: Thromboangiitis Obliterans; Arteritis; Peripheral Arterial Disease
Intervention: Autologous Purified CD34+ Cells, Autologous Peripheral Blood Mononuclear Cells
April 16, 2016
146
NCT00872326
Completed
Completed
Autologous Bone Marrow Derived Mononuclear Cells in Treating Diabetic Patients With Critical Limb Ischemia
Conditions: Peripheral Vascular Diseases; Diabetic Foot
Intervention: Autologous Bone Marrow Mononuclear Cells
Conditions: Peripheral Vascular Diseases; Diabetic Foot
Intervention: Autologous Bone Marrow Mononuclear Cells
November 13, 2014
147
NCT00060996
Terminated
Terminated
Study of Remodulin in Patients With Critical Limb Ischemia With No Planned Revascularization Procedures
Conditions: Critical Limb Ischemia; Peripheral Vascular Disease; Foot Ulcers; Rest Leg Pain
Intervention: Remodulin® (treprostinil Sodium) Injection
Conditions: Critical Limb Ischemia; Peripheral Vascular Disease; Foot Ulcers; Rest Leg Pain
Intervention: Remodulin® (treprostinil Sodium) Injection
March 5, 2013
148
NCT02235675
Completed
Completed
Tack Optimized Balloon Angioplasty Below the Knee (TOBA - BTK) Study
Conditions: Critical Limb Ischemia; Peripheral Artery Disease
Intervention: Tack-It Endovascular System
Conditions: Critical Limb Ischemia; Peripheral Artery Disease
Intervention: Tack-It Endovascular System
March 7, 2017
149
NCT01260870
Terminated
Terminated
European Study of POBA Versus Cotavance(R) Paclitaxel Coated Balloon for the Treatment of Infrapopliteal Lesions in Critical Limb Ischemia (EURO CANAL)
Conditions: PAD
Intervention: Cotavance Paclitaxel Coated Balloon, Standard Balloon Angioplasty
Conditions: PAD
Intervention: Cotavance Paclitaxel Coated Balloon, Standard Balloon Angioplasty
June 5, 2015
150
NCT00955669
Completed
Completed
Comparison of Autologous Mesenchymal Stem Cells and Mononuclear Cells on Diabetic Critical Limb Ischemia and Foot Ulcer
Conditions: Autologous Transplantation; Diabetic Foot
Intervention: Symptoms And Objective Examination
Conditions: Autologous Transplantation; Diabetic Foot
Intervention: Symptoms And Objective Examination
November 30, 2010
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In Phase 1 (Phase I) clinical trials, researchers test a new drug or treatment in a small group of people (20-80) for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
In Phase 2 (Phase II) clinical trials, the study drug or treatment is given to a larger group of people (100-300) to see if it is effective and to further evaluate its safety.
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ia0006
actg 076
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It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
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Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
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Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the sponsor is decided by the data provider.
Searching this area will look in both the sponsor field and in the collaborators field. To only look in the sponsor field, use the Sponsor (Lead) search box.
When the Exact Match checkbox is checked, the name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Examples:
National Cancer Institute
Mayo Clinic
Bristol-Myers Squibb
Outcome Measures
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Outcome measures are used to evaluate trial results. For example, an obesity treatment
might be evaluated by a measure of weight loss after 6 months. Measures can also be used
to quantify side effects, such as number of myocardial infarctions,
number of patients with heart arrhythmia, number of suicides, etc.
Use this box to specify an outcome measure used to evaluate trial results.
Examples:
weight loss
heart failure
suicide
Interventions
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Interventions refer to the drug, vaccine, procedure, device, or other potential treatment being studied.
Interventions can also include less intrusive possibilities such as surveys, education, and interviews.
Use this box to specify drugs, devices, procedures, or vaccines used in a trial.
Examples:
clofibrate
cyclosporine
vitamin e
Conditions
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Conditions usually refer to a disease, disorder, syndrome, illness, or injury. In ClinicalTrials.gov,
conditions include any health issue worth studying, such as lifespan, quality of life, health risks, etc.
Use this box to specify the conditions being studied.
Examples:
lupus
heart attack
leukemia
risk factors for breast cancer
Study Type
There are three types of studies available in ClinicalTrials.gov:
There are three types of studies available in ClinicalTrials.gov:
Interventional:
Observational:
Expanded Access:
Studies where individuals are assigned to receive specific interventions.
Participants may receive diagnostic, therapeutic or other types of interventions.
Assignment of the intervention may or may not be random.
Individuals are tracked and biomedical and/or health outcomes are assessed.
Observational:
Studies without an intervention.
Studies where biomedical and/or health outcomes are assessed in a pre-defined group of individuals.
Participants may receive diagnostic, therapeutic, or other interventions, but the investigator
does not assign specific interventions to the participants of the study.
Expanded Access:
Records describing the procedure for obtaining an experimental drug or device for patients who
are failing on currently available treatments for their condition and also are unable to
participate in ongoing clinical trials. Expanded Access records are used to register all
types of non-protocol access to experimental treatments, including protocol exception,
single-patient IND, treatment IND, compassionate use, emergency use, continued access and parallel track.
Study Results
Searches can be restricted to studies with or without results.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
The inclusion of study results is a relatively new feature of ClinicalTrials.gov. Collection of results began in September of 2008. Almost all older studies and some newer studies do not include results. As time goes on, there will be more results available.
Recruitment Status
Also known as Enrollment Status.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Not all clinical trials in this database are accepting new participants. If you are looking for studies that are currently recruiting participants, will be recruiting in the future, or are about drugs that are available for expanded access, select Open Studies in the recruitment menu.
If you are interested in all trials, whether they are recruiting new participants or not, leave the menu with All Studies selected.
Trials may not be recruiting because they are full, completed, or halted for various reasons. In addition, some trials have very restrictive eligibility requirements and must seek participants by invitation only. To see these studies, Select Closed Studies in the recruitment menu.
Full list of all possible recruitment status values:
Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Search Terms
Use this box to specify general search terms found anywhere in the trial record.
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Multiple terms can be separated by an AND (all uppercase).
Examples:
type ii diabetes
veterans affairs medical center
heart attacks in older adults
nhlbi AND heart disease
Cisplatin AND safety study
Help for Searching clinical trials
Help Topics:
Basic Search:
On the Basic Search page, enter a word or word(s) that you want to use to find studies.
These may include diseases, interventions, and/or locations.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Medical terms are often several words long, such as Percutaneous Coronary Intervention. To only find studies where the words are together as a phrase, put the term in quotes (e.g., "Percutaneous Coronary Intervention"). If you search for a multi-word term without quotes, studies with all words together as a phrase will appear higher in the results list than studies where the words are separated and spread throughout the document. For example, a search for Heart Attack will list a study about,
Use of a Pacemaker Following a Heart Attack.
higher than the study,
Heart Defects and Transient Ischemic Attacks
A search for "Heart Attack" would not find the second study. Synonyms are known for some terms and are used where possible. For example, a search for Heart Attack will also find occurrences of Myocardial Infarction.
Advanced Search:
Many searches are a single term and can be performed with a few words in the
search box. But, sometimes you need more control. Click on the Advanced Search tab
(if starting a new search) or Refine Search tab (if modifying an existing search)
to show additional search fields.
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Recruitment:
Interventions:
Outcomes Measures:
Sponsor/Collaborators:
Sponsor (Lead):
Study IDs:
Country/State:
Location Terms:
Gender:
Age Group:
Phase:
Funded By:
Safety Issue:
First Received:
Last Updated:
The additional search fields can be used to limit your search results. Note that it is not necessary to fill in all the fields, only those that are needed for your search. If you are finding too few studies, consider clearing a field and searching again.
Search Terms:
Performs a general search in all sections of the study record, including title,
description, conditions, interventions, locations, etc. Terms in this field are
searched the same as Basic Search.
Recruitment:
Limits search results to studies that are open or closed. New volunteers may be
able to participate in open studies, but not closed studies.
Open recruitment status values:
Closed recruitment status values:
Values are color coded (as shown) in the search results.
Study Results:Open recruitment status values:
Recruiting,
Not yet recruiting, or
Available for expanded access.
Not yet recruiting, or
Available for expanded access.
Closed recruitment status values:
Active, not recruiting,
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Completed,
Terminated,
Suspended,
Withdrawn,
Enrolling by invitation,
Temporarily not available for expanded access,
No longer available for expanded access,
Approved for marketing, or
Unknown.
Values are color coded (as shown) in the search results.
Limits search results based on whether the study has results or not:
Study Type:
All Studies,
Studies With Results, or
Studies Without Results
The inclusion of Study Results is a new feature of ClinicalTrials.gov.
Only a few studies have results available.Studies With Results, or
Studies Without Results
Limits search results to any of the following study types:
Conditions:
Interventional,
Observational, or
Expanded Access
Observational, or
Expanded Access
Performs a search on fields describing the diseases or conditions being studied.
Interventions:
Performs a search on fields listing the drugs or interventions being studied.
Outcomes Measures:
Performs a search on fields listing the outcome measures used to quantify study results.
Sponsor/Collaborators:
Performs a search on fields listing the sponsor and collaborators of a study.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
When the Exact Match checkbox is checked, the sponsor/collaborator name in the study must exactly match the name in the search. For example, if unchecked, a search for Merck in the sponsor/collaborator field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Sponsor (Lead):
Performs a search on the sponsor field of a study.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
It is common for several organizations to collaborate by providing funding, facilities, experimental treatments, etc. Which organization is considered the "sponsor" is decided by the data provider.
When the Exact Match checkbox is checked, the lead sponsor name in the study must exactly match the lead sponsor name in the search. For example, if unchecked, a search for Merck in the lead sponsor field will find Merck, Merck KGaA, Dupont Merck, and Merck Sharp & Dohme. When checked, only Merck, with no other words in the name, will be found.
Study IDs:
Performs a search on fields listing ID numbers.
Country/State:
Trials are often conducted at many locations around the world.
Select up to three locations to find trials conducted in
specific countries. Some countries (currently limited to the
United States, Canada, and Australia), locations can be narrowed
further by selecting a state (e.g., United States, Alabama).
Location Terms:
Finds studies in specific locations such as a city (Los Angeles) or facility (Mayo Clinic).
Not all studies include this level of detail, but if they do, this will find them.
Gender:
Limits search results to those studies that accept female or male participants.
Age Group:
Limits search results to those studies that include at least one of the specified age
ranges. More than one age group can be selected.
Phase:
Limits search results to studies that are labeled with at least one of the specified
phases. More than one Phase can be selected.
Funded By:
Limits search results to studies that have at least one sponsor of the specified types.
More than one sponsor type can be selected.
Safety Issue:
Limits search results to studies that have at least one outcome measure designated as a safety issue.
First Received:
Limits search results to studies that were received by clinical trials within a
specified date range. The "From" or "To" field can be left blank.
Last Updated:
Limits search results to studies that were modified within a
specified date range. The "From" or "To" field can be left blank.
Refine Search:
Searches display a list of studies found (List Results tab). If you are not content with
the search results, click on the Refine Search tab at the top of the list to modify your
search.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
When you are done making changes, click Search to display the new results.
Add terms to empty fields to search within your current result. You can also add terms to fields that contain terms. For best results, use an AND (all upper case) as a separator between terms in the same field.
For example:
heart attack
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
heart attack AND aspirin
heart attack AND aspirin AND older adults
heart attack AND aspirin AND older adults AND California
When you are done making changes, click Search to display the new results.
Search Expressions:
Use AND (all upper case) to find study records that contain all terms connected by AND.
For example:
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.
For example:
prostate cancer AND radiation
heart disease AND stroke AND California
heart disease AND stroke AND California
Use OR (all upper case) to find study records that contain either term connected by OR.
For example:
Aspirin OR ibuprofen
heart disease OR heart attack
heart disease OR heart attack
Use NOT (all upper case) to find study records that do not contain the term following NOT.
For example:
Immunodeficiency NOT AIDS
Likewise, AND, OR, NOT, and parentheses can be used to create more complicated search expressions.
For example:
prostate cancer AND NOT ( radiation OR homeopathic remedies )
( heart disease OR heart attack ) AND ( stroke OR clot )
( heart disease OR heart attack ) AND ( stroke OR clot )
Note that the use of AND and OR as logical operators can be confusing.
An appropriate search for a list such as,
Ear, Nose, and Throat Conditions
is the expression
( Ear OR Nose OR Throat ) AND Conditions
Fortunately, search will do a pretty good job of finding the right studies either way.To search for AND as a word, instead of using it as an operator, put it in quotes.
Likewise, you can quote OR, NOT, and parentheses.